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Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.38M | Year: 2013

The SO2S network seeks to exploit Singlet Oxygen (1O2) as a green and benign oxidant for use in novel synthetic methodologies, crosslinking strategies, bioconjugation procedures and materials production. The chemistry described herein generates the means to both understand and influence biological systems by providing probes and reagents from analytical methods to new drugs - and to modulate materials towards optimal properties. Training in this area is highly interdisciplinary in nature requiring the joint efforts and contributions of chemists, physicists, biologists and material scientists. Ultimately our understanding and further development of singlet oxygen mediated oxidations should lead to useful applications in the fields of organic chemistry (improved routes towards natural products), medicinal chemistry (targeted delivery and novel diagnostics), physical chemistry (controlled singlet oxygen generation), and materials science (novel materials for water treatment and new arrays for improved diagnostics). The global objective of this network is to train young researchers to become skilled individuals that meet the current challenges of working in an interdisciplinary industrial environment wherein chemistry often forms the basis, but where it is utilized in a truly diverse range of applications.

Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.67M | Year: 2013

Biosensor development is a very promising and prospective field of research in food- clinical- and environmental analysis. Besides conventional analytical methods biosensors specifically detect only some decisive components. However, miniaturised sensor systems are able to detect components in the femto/ato-gramm region with almost no interference to other components in the investigated system. The advantage of such technologies is beside the high sensitivity/selectivity, the cost reduction and the very fast response of such analytic systems. Complex sensor systems will be developed for multiple parameter sensing on real samples combined with signal enhancement strategies. The network created by SAMOSS will improve the further development of biosensors in combination with optochemical sensing techniques in the fields of application and by broader distribution of knowledge. The main topics of the development will comprise the research and development of new materials for optochemical sensing and microfluidic applications, microfluidic sample handling modules, multifunctional elements, signal enhancement and innovative detection systems. SAMOSS will create a European Centre of Excellence for training young researchers in Biosensor Research and Development suited for Applications in Medicine, Food and Beverage Technologies as well as Environmental issues. Through well trained researchers SAMOSS will provide widely skilled personnel for a) the European Biosensor Research in Academia and b) the European Biosensor Industry. As a European Centre of Excellence SAMOSS will deliver a flexible and adaptable network of young researchers that is capable to accomplish the European needs in research and development of new, innovative biosensors for food and beverage analysis, environmental analysis and health care. Thus they will be well trained to become future team leaders in these research and development fields, whether in the domain of academia or in the private sector.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: OCEAN 2013.1 | Award Amount: 4.56M | Year: 2013

BRAAVOO aims to develop innovative solutions for real-time in-situ measurements of high impact and difficult to measure marine pollutants. The concept of BRAAVOO is based on a unique combination of three types of biosensors, which will enable both the detection of a number of specific marine priority pollutants as well as of general biological effects that can be used for early warning. First, innovative bimodal evanescent waveguide nanoimmuno-sensors will enable label-free antibody-based detection of organohalogens, antibiotics, or algal toxins. Secondly, bacterial bioreporters producing autofluorescent proteins in response to chemical exposure will enable direct detection of alkanes or PAHs from oil, heavy metals, or antibiotics, and can further assess the general toxicity of the water sample. Finally, the photosystem activity of marine algae is exploited to monitor changes induced by toxic compounds. BRAAVOO will construct and rigorously test the three biosensor systems for their analytical performance to the targeted pollutants. To enable low-cost real-time measurements, the three biosensors will be miniaturized, multiplexed and integrated into innovative modules, which allow simultaneous multianalyte detection. The modules will include all optical elements for biosensor signal generation and readout, the microelectronics for data storage, and specific microfluidics to embed the biosensors or cells, and expose them to aqueous samples from dedicated autosamplers. The modules can be used either as stand-alone instruments for specific marine applications or can operate autonomously and in real-time in an integrated form. Hereto, they will be embedded in a marine buoy and an unmanned surveying vessel. Vessels and stand-alone biosensor modules will be tested extensively and in comparative fashion on real marine samples and in mesocosms. If successful, the flexible and innovative BRAAVOO solutions will democratize and revolutionize marine environmental monitoring.

Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2009.3.3 | Award Amount: 4.16M | Year: 2010

Backgroung\nThe main purpose of this project is the development of the Laser-Induced Forward Transfer (LIFT) process that permits the deposition of a wide variety of materials, with high spatial resolution (a few micrometers) for the manufacturing of electronic devices. It has been successfully applied so far in laboratory-scale trials for the deposition of organic and inorganic compounds, polymers and biomaterials on various substrates and the realisation of devices such as OLEDs or TFTs.\nBreakthrough\nThis process will address the same market as inkjet printing, but it should be significantly faster, doesnt require any post-annealing, allows for the deposition of multilayer structures without any risk of undesirable material mixing and can enable printing of a wide range of materials and phases. The ability of printing such a diverse range of materials with a unique process opens up new perspectives for increasing the performances of devices.\nObjectives\nThe aim of the present project is to integrate the expertise in laser physics, chemistry and microelectronics from academics, integrators and product manufacturers from industry in order to validate this technology, define its capabilities and its limits, and finally to ensure its successful transfer towards real-world applications in manufacturing.\n- Our first objective is to optimize the LIFT process for representative materials and substrates (flexible and rigid) in order to solve the potential technological blocking points and to determine the process windows.\n- The second objective is to validate the LIFT process. Some specific applications will be addressed and that will lead to the realisation and characterisation of components like TFTs, OLEDs, sensors, energy harvesters, and the laser printing of the most promising of these composites onto RFID tags.\nThis scientific effort will pave the way to the definition of the laser printing prototype together with reliability and productivity considerations.

Agency: European Commission | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.38M | Year: 2009

The objective of BEEP-C-EN is the integration of innovative biosensor research and technology and their exploitation by industry and/or other socio-economic entities in the fields of environment and agro-industry. The first target application is the detection of pesticides, heavy metal and organic compounds in water. The aim is building up a biosensor modular industrial platform, which can be easily adopted for multi-parameter/multi-sensor design and production. It consists of a series of electrochemical-optical sensors and microsystems suitable for various biomediators (microrganisms, DNA, proteins or cells) and based on new technologies studied and developed by the research performers in the consortium. The transduction approach is suggested by two main biomediator properties, often exploited in biosensor operation in response to analyte or modification of a physical-chemical condition: the variation of the bioluminescence/fluorescence emission and the internal electrical behaviour. These changes when transduced to readable electrical signals can give complementary information: the modification of a current signal is correlated to the electrogenic property of the biomediator (e.g. inhibition of Photosystem II electron transfer in the presence of a pesticide), while a modificaton of fluorescence is often correlated to a conformational modification (e.g. interaction of Photosystem II protein with ionizing radiation). The specific proposed devices are: 1) MultiLights: modular optical transducer for autonomous measurements of bioluminescence/fluorescence of several biomediators assembled in series; 2) MultiAmps: modular electrochemical transducer for measurements of current and voltage variations; 3) MultiTasks: a multitransduction biosensor based on simultaneous and autonomous measurement either of bioluminescence either of current variations.

The purpose of this 2-years project is to develop sensors and biosensors for on-line monitoring growth parameters of industrial bioprocesses for the production of algal biomass and antioxidant compounds such as Xanthophylls. As a model for the design and in-field testing, the following industrial process and culture system have been selected: the natural production of Astaxanthin from the green microalga Haematococcus pluvialis in a tubular photobioreactor. Key parameters such as biomass, pigment content and accumulation profile during the induction process are now experimentally determined offline everyday at commercial production sites by means of complex manual analyses. This routine monitoring further increases production costs, being critical time consuming and requiring manpower. This is a major challenge faced by microalgae companies today, especially in the production of natural carotenoids in comparison with the relatively cheap synthetic analogues. SENSBIOSYN intends to offer a solution to the lack of existing devices able to provide online rapid automatic and reliable information on active compounds accumulation profile and efficacy during their biosynthesis. The proposed project will bring the following competitive advantages to microalgae companies: Increased production - online monitoring will ease decision about time of harvest and culture performance; Reduction of production cost - the introduction of the proposed biosensors in the process control will allow to save work time and manpower and reduce the production cost by at least 30%, which is a big industrial breakthrough. Two optical sensors, for chlorophyll fluorescence measurement and culture medium density, and two electrochemical biosensors, based on the direct measurement of Phosphatidylcholine peroxidative damage by screen printed electrodes and the PSII activity by nanowire FETs, will be manufactured.

Boutopoulos C.,National Technical University of Athens | Touloupakis E.,National Research Council Italy | Touloupakis E.,Biosensor Srl | Pezzotti I.,Biosensor Srl | And 2 more authors.
Applied Physics Letters | Year: 2011

This letter demonstrates the direct laser printing of photosynthetic material onto low cost nonfunctionalized screen printed electrodes for the fabrication of photosynthesis-based amperometric biosensors. The high kinetic energy of the transferred material induces direct immobilization of the thylakoids onto the electrodes without the use of linkers. This type of immobilization is able to establish efficient electrochemical contact between proteins and electrode, stabilizing the photosynthetic biomolecule and transporting electrons to the solid state device with high efficiency. The functionality of the laser printed biosensors was evaluated by the detection of a common herbicide such as Linuron. © 2011 American Institute of Physics.

Touloupakis E.,National Research Council Italy | Touloupakis E.,Biosensor Srl | Boutopoulos C.,National Technical University of Athens | Buonasera K.,National Research Council Italy | And 2 more authors.
Analytical and Bioanalytical Chemistry | Year: 2012

One of the limits of current electrochemical biosensors is a lack of methods providing stable and highly efficient junctions between biomaterial and solid-state devices. This paper shows how laser-induced forward transfer (LIFT) can enable efficient electron transfer from photosynthetic biomaterial immobilized on screen-printed electrodes (SPE). The ideal pattern, in terms of photocurrent signal of thylakoid droplets giving a stable response signal with a current intensity of approximately 335∈±∈13 nA for a thylakoid mass of 28∈±∈4 ng, was selected. It is shown that the efficiency of energy production of a photosynthetic system can be strongly enhanced by the LIFT process, as demonstrated by use of the technique to construct an efficient and sensitive photosynthesis-based biosensor for detecting herbicides at nanomolar concentrations. © 2012 Springer-Verlag.

Lavecchia T.,Biosensor S.R.L
Advances in Experimental Medicine and Biology | Year: 2010

The importance of safety and functionality analysis of foodstuffs and raw materials is supported by national legislations and European Union (EU) directives concerning not only the amount of residues of pollutants and pathogens but also the activity and content of food additives and the health claims stated on their labels. In addition, consumers' awareness of the impact of 'functional foods' on their well-being and their desire for daily healthcare without the intake pharmaceuticals has immensely in recent years. Within this picture, the availability of fast, reliable, low cost control systems to measure the content and the quality of food additives and nutrients with health claims becomes mandatory, to be used by producers, consumers and the governmental bodies in charge of the legal supervision of such matters. This review aims at describing the most important methods and tools used for food analysis, starting with the classical methods (e.g., gas-chromatography GC, high performance liquid chromatography HPLC) and moving to the use of biosensors-novel biological material-based equipments. Four types of biosensors, among others, the novel photosynthetic proteins-based devices which are more promising and common in food analysis applications, are reviewed. A particular highlight on biosensors for the emerging market of functional foods is given and the most widely applied functional components are reviewed with a comprehensive analysis of papers published in the last three years; this report discusses recent trends for sensitive, fast, repeatable and cheap measurements, focused on the detection of vitamins, folate (folic acid), zinc (Zn), iron (Fe), calcium (Ca), fatty acids (in particular Omega 3), phytosterols and phytochemicals. A final market overview emphasizes some practical aspects of biosensor applications. © 2010 Landes Bioscience and Springer Science+Business Media, LLC.

Agency: European Commission | Branch: H2020 | Program: SME-1 | Phase: NMP-25-2014-1 | Award Amount: 71.43K | Year: 2015

The Drinking Water Treatment Industry is subject to a stringent legislation regarding contaminants in water. Quality of water intended for human consumption and its monitoring are regulated under the drinking water directive 98/83/CE. Pesticides and heavy metals must be monitored and tested regularly with maximum allowable concentration of 0.1 g/l for individual pesticides and 0.5 g/l for the total amount of pesticides. The directive 2013/39/EU concerning emerging contaminants to be controlled in the field of water policy establishes what contaminants are identified for priority action at Union Level. Most important for the Drinking Water Treatment Industry is the cost associated to contaminants detection: approximately 160millions are invested in pesticide water analysis in Europe. Currently, a pesticide analysis costs an average of 300 per sample since it requires specific staff and high technology equipments. We have developed a prototype of BEEP-WATER biosensor technology able to detect and quantify on site a wide range of chemical contaminants including pesticides, heavy metals and emerging contaminants in water saving the cost associated to current laboratory analysis. The objective of our current project is the industry adaptation and implementation in the Drinking Water Treatment Industry of BEEP WATER early warning system as a real quick and inexpensive alternative to current contaminant analysis systems in water.

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