Novato, CA, United States

Biosearch Technologies, Inc

www.biosearchtech.com
Novato, CA, United States
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Patent
Biosearch Technologies, Inc | Date: 2017-03-15

The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.


Patent
Biosearch Technologies, Inc | Date: 2017-03-08

The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure XO-CH2-SM-B-A. The substituent X is H, an acid labile protecting group, a solid support, -P(O-R1)NR2R3, - P(O)(OH)H, -P(O)(OR1)H, -P(O)(OH)2, -P(O)(OH)O-P(0)(OH)OP(O)(OH)2 or salts thereof. The substituent R1 is CNE (i.e., cyanoethyl), alkyl, or heteroalkyl and R2 and R3 are independently alkyl. The substituent SM is a sugar moiety or analogue thereof that is not a natural furanosyl, B is a base moiety or analogue thereof, and A is a moiety attached to a nitrogen on or in the base moiety of the structure -C(O)OR4, wherein R4 is tertiary alkyl.


Patent
Biosearch Technologies, Inc | Date: 2015-05-11

The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.


Patent
Biosearch Technologies, Inc | Date: 2016-04-15

The present invention provides nucleic acid probes comprising two quenchers of excited state energy, and methods of their use.


Patent
Biosearch Technologies, Inc | Date: 2014-01-17

The present invention provides a family of dark quenchers, termed Black Hole Quenchers (BHQs), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.


Patent
Biosearch Technologies, Inc | Date: 2014-03-17

The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.


Patent
Biosearch Technologies, Inc | Date: 2016-01-19

The present invention generally relates to coumarin-based compounds that can be used for the labeling of biological molecules, as well as related synthetic and testing methods. The coumarin-based compounds typically survive conditions necessary for automated synthesis of nucleic acids without undergoing any substantial degree of degradation or alteration.


Patent
Biosearch Technologies, Inc | Date: 2015-04-15

The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure XOCH_(2)SM-B-A. The substituent X is H, an acid labile protecting group, a solid support, P(OR^(1))NR^(2)R^(3), P(O)(OH)H, P(O)(OR^(1))H, P(O)(OH)_(2), P(O)(OH)OP(O)(OH)OP(O)(OH)_(2 )or salts thereof. The substituent R^(1 )is CNE (i.e., cyanoethyl), alkyl, or heteroalkyl and R^(2 )and R^(3 )are independently alkyl. The substituent SM is a sugar moiety or analogue thereof that is not a natural furanosyl, B is a base moiety or analogue thereof, and A is a moiety attached to a nitrogen on or in the base moiety of the structure C(O)OR^(4), wherein R^(4 )is tertiary alkyl.


Patent
Biosearch Technologies, Inc | Date: 2015-03-30

The present invention provides a family of dark quenchers, termed Black Hole Quenchers (BHQs), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.


Patent
Biosearch Technologies, Inc | Date: 2014-07-23

The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex, or higher order aggregation (e.g. hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g. intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g. alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.

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