Bioretec Ltd

Tampere, Finland

Bioretec Ltd

Tampere, Finland

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Frantzen J.,University of Turku | Palli A.,University of Tampere | Kotilainen E.,University of Turku | Heino H.,Bioretec Ltd. | And 13 more authors.
International Journal of Biomaterials | Year: 2011

A poly-70L/30DL-lactide (PLA70)-β-tricalcium phosphate (β-TCP) composite implant reinforced by continuous PLA-96L/4D-lactide (PLA96) fibers was designed for in vivo spinal fusion. The pilot study was performed with four sheep, using titanium cage implants as controls. The composite implants failed to direct bone growth as desired, whereas the bone contact and the proper integration were evident with controls 6 months after implantation. Therefore, the PLA70/β-TCP composite matrix material was further analyzed in the in vitro experiment by human and ovine adipose stem cells (hASCs and oASCs). The composites proved to be biocompatible as confirmed by live/dead assay. The proliferation rate of oASCs was higher than that of hASCs at all times during the 28d culture period. Furthermore, the composites had only a minor osteogenic effect on oASCs, whereas the hASC osteogenesis on PLA70/β-TCP composites was evident. In conclusion, the composite implant material can be applied with hASCs for tissue engineering but not be evaluated in vivo with sheep. Copyright © 2011 Janek Frantzén et al.


Paakinaho K.,Tampere University of Technology | Heino H.,Tampere University of Technology | Heino H.,Bioretec Ltd | Vaisanen J.,Tampere University of Technology | And 2 more authors.
Journal of the Mechanical Behavior of Biomedical Materials | Year: 2011

The hydrolytic degradation of oriented poly(L-lactide-co-glycolide) 85L/15G (PLGA 85/15) sample materials with various amounts of lactide monomer was monitored in vitro at 37 °C. The materials were manufactured from medical grade PLGA 85/15 by a two-step melt extrusion-die drawing process. Results showed that the hydrolytic degradation rate depended highly on the lactide monomer content, which in turn influenced the retention of mechanical properties, mass loss, crystallinity, and dimensional stability. Even small quantities of lactide monomer (0.05-0.20 wt%) affected especially the retention of mechanical properties, which started to decline rapidly upon the inherent viscosity reaching 0.6-0.8 dl/g due to hydrolytic degradation. Based on our hydrolytic degradation data, we constructed a simplified mathematical model of degradation-related strength retention and recommend it as a functional quality control tool for melt-processed biodegradable medical devices manufactured from poly(L-lactide-co-glycolide) 85L/15G. © 2011 Elsevier Ltd.


Paakinaho K.,Tampere University of Technology | Heino H.,Tampere University of Technology | Heino H.,Bioretec Ltd. | Pelto M.,Tampere University of Technology | And 3 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2012

This study reports of the novel water-induced shape-memory of bioabsorbable poly(D,L-lactide). We have developed an orientation-based programming process that generates an ability for poly(D,L-lactide) to transform its shape at 37°C in an aqueous environment without external energy and to adapt to a predefined stress level by stress generation or relaxation. In this orientation-programming process, polymer material is deformed and oriented at an elevated temperature and subsequently cooled down while retaining its deformed shape, tension, and polymer chain entanglements. At body temperature and in an aqueous environment, the shape-memory is activated by the plasticizing effect of water molecules diffused into the polymer matrix causing an entropy-driven directed relaxation of oriented and preloaded polymer chains. This plasticizing effect is clearly seen as a decrease of the onset glass transition temperature by 10-13°C. We found that c-irradiation used for sterilizing the orientation-programmed materials strongly affected the shape-recovery rate, but not the recovery ratio. Both non-γ-irradiated and c-irradiated sample materials showed excellent shape-recovery ratios during a ten-week test period: 94 and 97%, respectively. The orientation-programmed materials generated a predefined load in a 37°C aqueous environment when their shape-recovery was restricted, but when external tension was applied to them, they adapted to the predefined level by stress relaxation. Our results show that functionality in terms of shape-memory can be generated in bioabsorbable polymers without tailoring the polymer chain structure thus shortening the time from development of technology to its utilization in medical devices. © 2012 Springer Science+Business Media, LLC.


Ahola N.,Tampere University of Technology | Veiranto M.,Tampere University of Technology | Veiranto M.,Bioretec Ltd | Rich J.,Aalto University | And 4 more authors.
Journal of Biomaterials Applications | Year: 2013

There is an increasing need for synthetic bone substitute materials that decrease the need for allografts and autografts. In this study, composites of β-tricalcium phosphate and a biodegradable poly(L-lactide-co- Éε-caprolactone) were manufactured using extrusion to form biodegradable composites with high β-tricalcium phosphate contents for osteoconductivity. The hydrolytic degradation of the composites containing 0, 10, 20, 35 and 50% of β-tricalcium phosphate was studied in vitro for 52 weeks. During the study, it was observed that β-tricalcium phosphate did not have an effect on the degradation rate of the polymer matrix. However, the crystallinity of the materials increased throughout the test series and changes in glass transition temperatures were also observed as the comonomer ratio of the polymer matrix changed as the degradation proceeded. The results show that the materials have desirable degradation properties and, thus, possess great potential as bioabsorbable and osteoconductive bone filling materials. © 2012 The Author(s).


Notes:  Production, means the output of Cardiovascular Surgery Device  Revenue, means the sales value of Cardiovascular Surgery Device This report studies Cardiovascular Surgery Device in Global Market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with production, price, revenue and market share for each manufacturer, covering  AngioDynamics, Inc.  Bioretec Ltd.  Boston  CardioScout, LLC  Corazon Technologies, Inc.  Coromedic Ltd.  Endogene Ltd  EpiEP, Inc.  European Medical Contract Manufacturing B.V.  CardioPolymers, Inc. Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Cardiovascular Surgery Device in these regions, from 2011 to 2021 (forecast), like  North America  Europe  China  Japan  Southeast Asia  India  Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into  Type I  Type II  Type III  Split by application, this report focuses on consumption, market share and growth rate of Cardiovascular Surgery Device in each application, can be divided into  Application 1  Application 2  Application 3 Global Cardiovascular Surgery Device Market Research Report 2016  1 Cardiovascular Surgery Device Market Overview  1.1 Product Overview and Scope of Cardiovascular Surgery Device  1.2 Cardiovascular Surgery Device Segment by Type  1.2.1 Global Production Market Share of Cardiovascular Surgery Device by Type in 2015  1.2.2 Type I  1.2.3 Type II  1.2.4 Type III  1.3 Cardiovascular Surgery Device Segment by Application  1.3.1 Cardiovascular Surgery Device Consumption Market Share by Application in 2015  1.3.2 Application 1  1.3.3 Application 2  1.3.4 Application 3  1.4 Cardiovascular Surgery Device Market by Region  1.4.1 North America Status and Prospect (2011-2021)  1.4.2 Europe Status and Prospect (2011-2021)  1.4.3 China Status and Prospect (2011-2021)  1.4.4 Japan Status and Prospect (2011-2021)  1.4.5 Southeast Asia Status and Prospect (2011-2021)  1.4.6 India Status and Prospect (2011-2021)  1.5 Global Market Size (Value) of Cardiovascular Surgery Device (2011-2021) 2 Global Cardiovascular Surgery Device Market Competition by Manufacturers  2.1 Global Cardiovascular Surgery Device Production and Share by Manufacturers (2015 and 2016)  2.2 Global Cardiovascular Surgery Device Revenue and Share by Manufacturers (2015 and 2016)  2.3 Global Cardiovascular Surgery Device Average Price by Manufacturers (2015 and 2016)  2.4 Manufacturers Cardiovascular Surgery Device Manufacturing Base Distribution, Sales Area and Product Type 2.5 Cardiovascular Surgery Device Market Competitive Situation and Trends  2.5.1 Cardiovascular Surgery Device Market Concentration Rate  2.5.2 Cardiovascular Surgery Device Market Share of Top 3 and Top 5 Manufacturers  2.5.3 Mergers & Acquisitions, Expansion 3 Global Cardiovascular Surgery Device Production, Revenue (Value) by Region (2011-2016)  3.1 Global Cardiovascular Surgery Device Production by Region (2011-2016)  3.2 Global Cardiovascular Surgery Device Production Market Share by Region (2011-2016)  3.3 Global Cardiovascular Surgery Device Revenue (Value) and Market Share by Region (2011-2016)  3.4 Global Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.5 North America Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.6 Europe Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.7 China Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.8 Japan Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.9 Southeast Asia Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016)  3.10 India Cardiovascular Surgery Device Production, Revenue, Price and Gross Margin (2011-2016) 4 Global Cardiovascular Surgery Device Supply (Production), Consumption, Export, Import by Regions (2011-2016)  4.1 Global Cardiovascular Surgery Device Consumption by Regions (2011-2016)  4.2 North America Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016)  4.3 Europe Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016)  4.4 China Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016)  4.5 Japan Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016)  4.6 Southeast Asia Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016)  4.7 India Cardiovascular Surgery Device Production, Consumption, Export, Import by Regions (2011-2016) Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports understand how essential statistical surveying information is for your organization or association. Therefore, we have associated with the top publishers and research firms all specialized in specific domains, ensuring you will receive the most reliable and up to date research data available.

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