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Maguire G.,BioRegenerative Sciences
Expert Review of Molecular Diagnostics | Year: 2013

Systems biology is a recent addition to the necessary but insufficient reductionist approach used in biological research. Systems biology is focused on understanding living things as a function of their various interactions at multiple levels: not simply as a sum of all their individual parts at any one level. This integrative approach yields predictive models of the normal state, the disease state and therapeutic actions. Although molecular biology has collected an enormous amount of information, including the sequencing of the entire human genome in the year 2000, few real-world applications have resulted from this molecular approach. The pharmaceutical industry's R&D expenditure has increased substantially since 2000, but the number of approved therapeutics has dropped simultaneously, due in part to over-reliance on reductionist genomic, and not systems, approaches. Instead of using reductionist genomics approaches alone, genomics should be incorporated into a multi-level systems biology approach to develop diagnostics and therapeutics. © 2013 Informa UK Ltd.


Maguire G.,BioRegenerative Sciences
ACS Medicinal Chemistry Letters | Year: 2014

The standard drug development model uses reductionist approaches to discover small molecules targeting one pathway. Although systems biology analyzes multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. Similar to that in physics where a departure from the old reductionist "Copenhagen View" of quantum physics to a new and predictive systems based, collective model has emerged yielding new breakthroughs such as the LASER, a new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called "systems therapeutics." © 2014 American Chemical Society.


Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRMs) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRMs can be derived from one or more distinct cell lines. The SRMs can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.


Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (SRMs) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and SRMs can be derived from one or more distinct cell lines. The SRMs can further include one or more mucins, cytokines, or growth factors. Exemplary formulations include stem cells and SRMs derived from epithelial stem cells, corneal limbal stem cells, and fibroblasts. Other compositions and methods for formulation thereof are described.


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At BioRegenerative Sciences, Inc. we believe that Imagination, Empowerment, Creativity, and Integrity will help us bring the best stem cell-based health care products to the world-wide market in service to all humankind and to the animal kingdom ...

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