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Taipei, Taiwan

Lee S.H.,Inha University | Yun H.G.,Inha University | Lee M.-H.,Inha University | Choi S.H.,BiOptic Inc. | Kim K.H.,Inha University
Optics Communications | Year: 2013

Single-longitudinal-mode (SLM) operation characteristics of an erbium-doped fiber (EDF) ring laser with an EDF saturable absorber have been measured and compared under two different-wavelength control-pump cases. The main EDF ring cavity was pumped with a conventional 977-nm-wavelength gain-pump laser diode, the EDF saturable absorber section attached to the main cavity via an optical circulator was pumped with a control-pump-laser beam of either 980-nm or 1531.9-nm wavelength to deliver the ring-laser output of 1541.4-nm wavelength. Our experimental results indicate that the control-pump-laser beam in the 1530-nm-wavelength region provides higher output power and wider wavelength range of the SLM operation of the ring laser than that in the 980-nm-wavelength region does. © 2013 Elsevier B.V.

A cartridge-based bio-separation system configured to utilize a pen shaped bio-separation cartridge that is easy to assemble and use with no moving parts and that has an integrated reagent (separation buffer) reservoir. The cartridge includes a body, defining an opening as a detection window for receiving external detection optics, at least one capillary column supported in the body, having a first end extending beyond a first end of the body, wherein the detection window exposes a section along the capillary column, to which the external optics are aligned through the detection window, and a reservoir attached to a second end of the body in fluid flow communication with a second end of the capillary column. The reservoir is structured to be coupled to an air pressure pump that pressurizes the gel reservoir to purge and fill the capillaries with buffer as the separation support medium.

Bioptic Inc. | Date: 2014-06-24

A simple, low cost, efficient and stable micro-vial configuration for handling micro-volume of sample fluids. The interior wall geometry of the inventive vial is designed to include several axial sections of various interior diameters to provide a range of functionalities to address various design considerations. The interior wall defined in the vial has a cylindrical sample section, a wider cylindrical alignment section, a tapered or conical guide section, and a relatively large cylindrical body section, arranged in sequence in that order along the center axis of the vial. The sample section is designed to hold a small volume of a sample fluid, and to receive the tip end of a capillary tube. The alignment section has a larger diameter than the sample section, designed to receive a cylindrical support that coaxially supports the relatively fragile capillary tube. The tip of the capillary tube dips into the micro-volume of sample fluid held in the sample section. The conical section functions to guide the capillary tube and the support tube into the alignment section and the tip of the capillary tube into the sample section. The body section has the largest diameter, for holding additional fluid if desired.

A detection optics configuration for bio-analysis, in which the direction of incident radiation, the axis of the separation channel, and the direction of collection of the output radiation are coplanar at the detection zone. The detection configuration incorporates ball-end optical fibers to direct incident radiation at and collection of output radiation from the detection zone. The detection optics configuration may be implemented in an improved bio-separation instrument, in particular a capillary electrophoresis instrument.

Bioptic Inc. | Date: 2015-05-22

A method for glycan profiling by capillary electrophoresis (CE), and a CE system for glycan analysis (N-Glycan). The CE system uses integrated dual optical fibers for both radiation excitation and emission detection. The CE system is configured for performing a two-color detection for data analysis. A single radiation excitation source is used to excite two emission fluorophores or dyes in the sample solution to be analyzed. One emission dye is to tag the sample and the other dye is used to provide a reference marker (e.g., a Dextran Ladder) for the sample run. Two detectors (e.g., photomultipler tubes (PMTs)) are applied to simultaneously detect the fluorescent emissions from the dyes. The data collected by both detectors are correlated (e.g., synchronized, and/or super-positioned for analysis) for accurate data peak identification.

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