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Leipzig, Germany

Knapp S.,Helmholtz Center for Environmental Research | Gerth A.,BioPlanta GmbH | Klotz S.,Helmholtz Center for Environmental Research
World of Mining - Surface and Underground | Year: 2012

The Quang Ninh province in north-eastern Vietnam is home to opencast and belowground hard coal mining. To reduce environmental conflicts, the Vietnamese government decided that VINACOMIN has to recultivate waste rock dumps and find sustainable solutions for post-mining land use. From 2008 to 2011, the Helmholtz-Centre for Environmental Research, UFZ and the BioPlanta Corporation developed plant-based techniques for recultivation and mine water treatment on two waste rock dumps in Quang Ninh. VINACOMIN recultivated waste rock dumps by filling up top soil, planting fast-growing plant species and applying fertilizer. This mainly resulted in plant monocultures that require maintenance over several years. Planting species in mixed plantations instead of monocultures is beneficial for soil formation, reduces the risk of dump fires and pest infestations, and supports biodiversity. By planting a broad range of species, diverse options for post- mining land use was created.

Perez-Alonso N.,University "Marta Abreu" of Las Villas | Capote A.,University "Marta Abreu" of Las Villas | Gerth A.,BioPlanta GmbH | Jimenez E.,University "Marta Abreu" of Las Villas
Plant Cell, Tissue and Organ Culture | Year: 2012

Digitalis lanata is an important source of cardenolides such as digoxin and lanatoside C, which have been widely applied in the treatment of cardiac insufficiencies. Elicitation is one of the most effective methods to enhance the biosynthesis of several secondary metabolites in medicinal plants. We studied the effect of elicitation with Chitoplant®, Silioplant® and methyl jasmonate on biomass and cardenolides accumulation in shoots of D. lanata cultivated in temporary immersion systems. Morphological response of the shoots was influenced by elicitors. A reduction in length and number of shoots was evident with all MJ concentrations. Regarding biomass production, Chitoplant® (0. 1 g l -1) was found to impact significantly on fresh and dry weight of the shoots. HPLC analysis revealed a higher content of lanatoside C compared to digoxin in all treatments. The highest accumulation of lanatoside C was achieved with Chitoplant® (0. 1 g l -1), which resulted in 316 μg g-DW -1 and with Silioplant® (0. 01 g l -1; 310 μg g-DW -1), which accounted for a 2. 2-fold increase in lanatoside C content compared to non-elicited shoot cultures. Additionally, elicitation of D. lanata shoots in temporary immersion systems resulted in an oxidative stress characterized by hydrogen peroxide and malondialdehyde accumulation. These observations point to a connection between hydrogen peroxide generation, lipid peroxidation and cardenolide accumulation. The optimization of elicitor treatment and culture conditions for cardenolide production as well as the advantages of TIS for this purpose are discussed. © 2012 Springer Science+Business Media B.V.

Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 1.34M | Year: 2009

Galanthamine is an alkaloid produced exclusively by plants of the family Amaryllidaceae, mainly belonging to the genus Galanthus, Leucojum and Narcissus. Owing to its acetylcholinesterase inhibitory activity, galanthamine is used and marketed for the treatment of the Alzheimers disease, among others. Although it is obtained by organic synthesis, galanthamine is also being extracted from natural sources. Both Galanthus and Leucojum plants are very widespread in the Eastern European countries, whereas Narcissus plants are mainly distributed in the Mediterranean region. For industrial purposes, Leucojum aestivum plants are gathered from wild populations in their natural habitat, which causes increasing problems regarding quality of the plant material as well as depletion pressure on the natural populations of L. aestivum. By development of an in vitro production method, both problems will be overcome. Narcissus confusus, an endemic species growing in Spain, was found to produce around two-fold higher amount of galanthamine than L. aestivum. Both plant species will also be propagated and subjected to further agronomic studies for the initiation of new crops of highly galanthamine-containing plants. Integrating both research approaches, the initiation of new crops of L. aestivum and N. confusus and the establishment of the in vitro production method, will result in the development of a sustainable production method of galanthamine. Since galanthamine in Europe is produced by highly specialised SMEs, significant improvement in this field can only be achieved by cooperation on European level. The co-operative research implemented in the SUPROGAL project will thus markedly improve the competitiveness of the involved SMEs.

Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.5-03 | Award Amount: 7.70M | Year: 2012

Water4Crops provides a combination of technical improvements in the field of bio-treatment and agricultural water use within a transdisciplinary identification of novel agri-business opportunities. Water4Crops aims at: a) developing innovative biotechnological wastewater treatments for improved water recycling, b) initiating the co-creation of alternative combinations of bio-treatment, recycling of high value elements, and combinations for bioproducts leading to a better commercialization of biotechnology and agricultural products in Europe and India, c)improving water use efficiency at field level through agronomics, plant breeding and locally adapted new irrigation technologies and accurate crop water requirement measurements techniques. Water4Crops will boost bio-based economy by applying a double track approach. First a comprehensive set of key Green-Economy technologies for: 1) valorization of volatile fatty acids; 2) obtaining: natural antioxidants (polyphenols), biopolymers (PHAs), energy (biomethane); 3) new substances for selective recovery of valuable products from wastewater; 4) tailoring effluent properties from decentralized innovative bioreactors; 5) low bio-sludge production by SBBG Reactors; 6) removal of organopollutants by nanobiocatalysts; 7) reduced clogging of wetlands; 8) virus monitoring detection assays; 9) suitable precision irrigation systems for reclaimed water; 10) new monitoring for increase crop water productivity; 11) understanding the genetic mechanisms regulating drought-adaptive traits across maize, sorghum, millet and tomato; 12) optimized waste water related combinations of species/genotypes x environment x management. Second, new product market combinations will be identified. The co-creation process will be organized by two Mirror cases (Emilia Romagna area in Italy and Hyderabad region in India) within a specific Science-Practice Interface (INNOVA platforms). Developing the new applications and business opportunities with regional enterprises and stakeholder will move India and Europe towards a Green Economy.

Schumann A.,BioPlanta GmbH | Berkov S.,Agrobioinstitute Dragan Tzankov Blvd. | Berkov S.,University of Barcelona | Claus D.,BioPlanta GmbH | And 3 more authors.
Applied Biochemistry and Biotechnology | Year: 2012

The production of galanthamine by shoots of Leucojum aestivum grown in different bioreactor systems (shaking and nonshaking batch culture, temporary immersion system, bubble bioreactor, continuous and discontinuous gassing bioreactor) under different culture conditions was studied. The influence of the nutrient medium, weight of inoculum, and size of bioreactor on both growth and galanthamine production was studied. The maximal yield of galanthamine (19.416 mg) was achieved by cultivating the L. aestivum shoots (10 g of fresh inoculum) in a temporary immersion system in a 1-L bioreactor vessel which was used as an airlift culture vessel, gassing 12 times per day (5 min). © Springer Science+Business Media, LLC 2012.

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