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Fullwood L.M.,University of Exeter | Fullwood L.M.,Biophotonics Unit | Iping Petterson I.E.,University of Exeter | Dudgeon A.P.,University of Exeter | And 5 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE | Year: 2016

Raman spectroscopy is a rapid technique for the identification of cancers. Its coupling with a hypodermic needle provides a minimally invasive instrument with the potential to aid real time assessment of suspicious lesions in vivo and guide surgery. A fibre optic Raman needle probe was utilised in this study to evaluate the classification ability of the instrument as a diagnostic tool together with multivariate analysis, through measurements of tissues from different animal species as well as various different porcine tissue types. Cross validation was performed and preliminary classification accuracies were calculated as 100% for the identification of tissue type and 97.5% for the identification of animal species. A lymph node sample was also measured using the needle probe to assess the use of the technique for human tissue and hence its efficiency as a clinical instrument. This needle probe has been demonstrated to have the capabilities to classify tissue samples based on their biochemical components. The Raman needle probe also has the potential to act as a diagnostic and surgical tool to delineate cancerous from non-cancerous cells in real time, thus assisting complete removal of a tumour. © 2016 SPIE. Source


Barr H.,Biophotonics Unit | Old O.,Biophotonics Unit | Almond M.,Biophotonics Unit | Kendall C.,Biophotonics Unit | And 4 more authors.
Materials Today: Proceedings | Year: 2015

The vibrational spectroscopy analytical methods offer several apparent advantages for immediate and real-time medical diagnosis. They are able detect subtle molecular changes that must be present prior to morphological tissue changes. As well as allowing molecular understanding of a diseases natural history, there are very important patient benefits; in particular as an 'optical biopsy' technique for immediate tissue diagnosis in real-time and thus guide immediate therapy. In addition they can be used as a 'digital staining' assisting the histopathologist in diagnosis; or as an automated process for histopathology classification. At present all cancer diagnostics remains reliant on an individual, or now, more frequently a double reported histopathological opinion. This is subjective, time consuming and expensive; with delay between diagnosis and treatment. Normal tissue is removed as a precaution to be certain that early cancer is not present. The correct diagnosis of very early lesions in a cancer pathway is now depends on consensus opinion from expert panels within a clinical trials situation in view of the problems of incorrect diagnosis. Excisional biopsy risks complications, and is dangerous in vulnerable areas. Agreement between pathologists on the presence of early disease is very variable. The delays to the patient pathway are very distressing and the cost is very substantial for our Health services. © 2015 The Authors. Elsevier Ltd. Source

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