Okemos, MI, United States
Okemos, MI, United States

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Nie B.,Michigan State University | Pestov D.,Biophotonic Solutions Inc. | Wise F.W.,Cornell University | Dantus M.,Michigan State University | Dantus M.,Biophotonic Solutions Inc.
Optics Express | Year: 2011

A double-clad Yb-doped all-normal-dispersion fiber laser with a narrow intra-cavity spectral filter is demonstrated to produce 22 nJ pulses at 42.5 MHz repetition rate. These pulses are characterized and compressed via mulitphoton intrapulse interference phase scan to as short as 42 fs and 10 nJ/pulse. Adaptive compression underlies the achievement of 250-kW peak power, which enables efficient second and third harmonic generation with spectra spanning 30 nm and 20 nm, respectively. © 2011 Optical Society of America.

Lozovoy V.V.,Michigan State University | Rasskazov G.,Michigan State University | Pestov D.,Biophotonic Solutions Inc. | Dantus M.,Michigan State University | Dantus M.,Biophotonic Solutions Inc.
Optics Express | Year: 2015

Nonlinear optical applications depend on pulse duration and coherence of the laser pulses. Characterization of high-repetition rate pulsed laser sources can be complicated by their pulse-to-pulse instabilities. Here, we introduce and demonstrate experimentally a quantitative measurement that can be used to determine the pulse-to-pulse fidelity of ultrafast laser sources. Numerical simulations and experiments illustrate the effect of spectral phase and amplitude noise on second and third harmonic generation. © 2015 Optical Society of America.

Freudiger C.W.,Harvard University | Min W.,Harvard University | Holtom G.R.,Harvard University | Xu B.,Biophotonic Solutions Inc. | And 2 more authors.
Nature Photonics | Year: 2011

Label-free microscopy that has chemical contrast and high acquisition speeds up to video rates has recently been made possible using stimulated Raman scattering (SRS) microscopy. SRS imaging offers high sensitivity, but the spectral specificity of the original narrowband implementation is limited, making it difficult to distinguish chemical species with overlapping Raman bands. Here, we present a highly specific imaging method that allows mapping of a particular chemical species in the presence of interfering species, based on tailored multiplex excitation of its vibrational spectrum. This is implemented by spectral modulation of a broadband pump beam at a high frequency (>1 MHz), allowing detection of the SRS signal of the narrowband Stokes beam with high sensitivity. Using the scheme, we demonstrate quantification of cholesterol in the presence of lipids, and real-time three-dimensional spectral imaging of protein, stearic acid and oleic acid in live Caenorhabditis elegans. © 2011 Macmillan Publishers Limited. All rights reserved.

Coello Y.,Michigan State University | Daniel Jones A.,Michigan State University | Gunaratne T.C.,Biophotonic Solutions Inc. | Dantus M.,Michigan State University
Analytical Chemistry | Year: 2010

A novel atmospheric pressure imaging mass spectrometry approach that offers improved lateral resolution (10 μm) using near-infrared femtosecond laser pulses for non-resonant desorption and ionization of sample constituents without the need of a laser-absorbing matrix is demonstrated. As a proof of concept the method was used to image a two-chemical pattern in paper. To demonstrate the ability of the approach to analyze biological tissue, a monolayer of onion epidermis was imaged allowing the chemical visualization of individual cells using mass spectrometry at ambient conditions for the first time. As the spatial resolution is currently limited by the limit of detection of the setup (∼500 fmol limit of detection for citric acid), improvements in sensitivity will increase the achievable spatial resolution. © 2010 American Chemical Society.

Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase I | Award Amount: 79.94K | Year: 2011

The technical goal of this proposal is to design and develop a comprehensive USPL architecture that automatically monitors and corrects the temporal, spatial, and spectral characteristics of the output pulses thereby eliminating the need for an expert laser operator. USPL computer control has been restricted to trivial aspects like on/off, power, and repetition rate. We propose the design and production of laser systems with automated pulse tailoring technology (USPL-APTT) that have the simplest user interface (Ready-to-Fire). Only when configuration (specific mission) requires or when used by a scientist (research), would one need full access to pulse shaping/monitoring modules. Otherwise, the USPL-APTT constantly monitors its performance and corrects any deviation using on-board pulse shaper without interrupting the laser output.. All adjustments are made through phase/amplitude spectral control without moving parts. To accomplish the technical goal the system must: measure the spectral and/or temporal properties of the pulse at the target, correct laser pulse"s spectral and temporal properties at the target, be modular in design to conform to different lasers, be capable of autonomous calibration and operation, continually monitor the operation of the system, adjusting when necessary. Incorporation into mobile/airborne USPL systems will require the tailoring technology to be compact and rugged.

Biophotonic Solutions Inc. | Date: 2012-02-07

Scientific apparatus, namely, pulse measurement, compression and shaping device for use with lasers.

Biophotonic Solutions Inc. | Date: 2012-04-24

Lasers for industrial, scientific and defense applications, not for medical use.

News Article | March 28, 2016
Site: www.spie.org

Biophotonic Solutions Inc.

News Article | October 1, 2013
Site: www.finsmes.com

Biophotonic Solutions Inc., an East Lansing, MI-based provider of automated laser pulse compression solutions, closed a $1m Series A funding. The round was led by the Michigan Angel Fund. Led by Kiyomi Monro, CEO, BSI develops ultrafast lasers with adaptive capabilities producing pulses in the multi-femtosecond range used for industrial, scientific, medical, and defense applications. The company’s products are based on proprietary technology, called “MIIPS”, which provides automated measurement and compression of ultrafast laser pulses, automatically delivering optimized laser light to the target.

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