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Duan Z.-F.,Zhaoqing University | Duan Z.-F.,Biopharmaceutical Research and Development Center | Shao L.,Zhaoqing University | Li S.-N.,Zhaoqing University
Yaoxue Xuebao | Year: 2015

Using bioactive compounds 7-hydroxy flavone, salicylaldehyde, cinnamic acid and 4-amino-5-mercapto-1, 2, 4-triazoles as starting materials, three new types of flavone derivatives containing 1, 2, 4-triazole structure were synthesized via different step reactions. These new compounds were characterized by 'HNMR, ESI-MS, IR and elemental analysis. Their scavenging effects on the superoxide radical (O2·-), hydroxyl radical (·OH), DPPH-radical and their total reduction activities were tested. The results showed that all of the compounds possessed some antioxidative activity at the concentration of 0.5 mg ·mL-1, but the scavenging ability of the target compounds was lower than that of the standard compound Vc.

Yang Z.-Z.,Biopharmaceutical Research and Development Center | Xu F.,Biopharmaceutical Research and Development Center | Ke Z.-L.,Biopharmaceutical Research and Development Center | Chen H.-Y.,Biopharmaceutical Research and Development Center | And 2 more authors.
Journal of Chemical Research | Year: 2013

1-Acyl-3,6-diphenyl-1,4-dihydro-1,2,4,5-tetrazines were prepared by treatment of 3,6-diphenyl-1,4- (or 1,2)-dihydro-1,2,4,5-tetrazine and an equimolar amount of an acyl chloride. Further reaction with another equivalent of an acyl chloride yielded 1,4(or 1,2)-diacyl-3,6-diphenyl-1,4(or 1,2)-dihydro-1,2,4,5-tetrazines. Their structures are confirmed by 1H NMR, IR, and mass spectra and by elemental analysis and X-ray diffraction. The experimental results are also validated by calculation of molecular stabilisation energies with the DFT calculations (B3LPY method). It can be shown that when alkanoyl chlorides are used, the products are the 1,4-dihydro-1,2,4,5-tetrazines, whereas acylation with aroyl chlorides affords 1,2-dihydro-1,2,4,5-tetrazines. © 2013 Publishing Technology.

Xu F.,Biopharmaceutical Research and Development Center | Yang Z.-Z.,Biopharmaceutical Research and Development Center | Zhang S.-J.,Zhejiang Chinese Medical University
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2013

A green and high-yielding synthetic route for the preparation of 5-(1,2-diselenolan-3-yl)pentanoic acid (SeA) was reported. Some SeA derivatives, N′-substituted benzylidene-5-(1,2-diselenolan-3-yl)pentanehydrazide, were prepared, and they were screened for their anticancer activity against human breast MCF-7, leukemia HL-60, cervixuterus Hela, and placental villus Bewo cancer cell lines. The minimum inhibitory concentrations (MICs) of the synthetic compounds showed moderate anticancer activity at low concentrations (0.5-5 μg/mL). © 2013 Copyright Taylor and Francis Group, LLC.

Xu F.,Biopharmaceutical Research and Development Center | Yang Z.Z.,Biopharmaceutical Research and Development Center | Jiang J.R.,Biopharmaceutical Research and Development Center
Journal of Chemical Research | Year: 2013

6-Selenolipoic acid was synthesised from ethyl 6, 8-dichlorooctanoate in a one pot reaction with water as solvent, and was further converted in three steps to 14 N-substituted benzylidene-5-(1, 2-thiaselenolan-3-yl) pentanehydrazides. The compounds exhibited moderate to high anticancer activities, some of them showing activity comparable to that of cisplatin.

Jin Q.,Biopharmaceutical Research and Development Center | Wu H.-G.,Biopharmaceutical Research and Development Center | Zhang X.-X.,Biopharmaceutical Research and Development Center | Ke Z.-L.,Biopharmaceutical Research and Development Center
Journal of the Marine Biological Association of the United Kingdom | Year: 2015

We studied the effects of four non-nutrient environmental factors (temperature, salinity, irradiance and pH) on the growth inhibition of the macroalgae Ulva pertusa (Chlorophyta) upon the microalgae Heterosigma akashiwo (Rhaphidophyta). Experiments were conducted in single-factor incubation and various two-factor combination experiments in which temperature (10, 15, 25 and 30°C), salinity (10, 20, 30 and 40 g kg−1 water), irradiance (20, 100, 200 and 400 μmol m−2 s−1), and pH (5.5, 7, 8.5 and 10) were varied systematically. The growth rates of U. pertusa and H. akashiwo and the rate of microalgal growth inhibition were altered significantly by changing some of the non-nutrient factors in both the single-factor and the two-factor experiments. The optimal growth conditions for U. pertusa were 20–25°C, salinity of 30 g kg−1, irradiance level of 200–400 μmol m−2 s−1, and pH 8.5–10; optimal conditions for H. akashiwo growth were 25°C, 30 g kg−1, 100 μmol m−2 s−1 and pH 8.5, respectively. The growth inhibitory influence of U. pertusa on H. akashiwo was strongest at 25°C with low salinity (10 g kg−1), high irradiance (400 μmol m−2 s−1) and high alkalinity (pH = 10). The results of this study may be helpful in the development of methods for using green macroalgae to control the proliferation of microalgae in harmful algal blooms (HABs). In particular, these findings provide guidance regarding optimum levels of non-nutrient environmental factors in confined areas, such as aquaculture factories. Copyright © Marine Biological Association of the United Kingdom 2015

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