Neumarkt in der Oberpfalz, Germany
Neumarkt in der Oberpfalz, Germany

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Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.22M | Year: 2016

The main goal of the MediHealth project is to introduce a novel approach for the discovery of active agents of food plants from Mediterranean diet and other global sources to promote healthy ageing. This will be achieved through an extended and well-balanced scheme of researchers secondments between 5 universities and 4 enterprises from EU & Associated countries as well as 4 universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing complementary expertise will be the base of this proposal. Plants from the Mediterranean diet and food plants from TC will be rationally selected and will be subjected to an integrated, interactive and comprehensive platform including in silico, in vitro (advanced cell-based assays), in vivo (flies and mice models) & metabolism assessment. Advanced analytical techniques will embrace the pharmacological evaluation process for the efficient isolation and identification of bioactive plant constituents. Pharmacological profiling of bioactive natural products as well as identification and synthesis of their metabolites will be carried out. Finally, to carry to the stage of development innovative products in the area of nutraceuticals/dietary supplements process-optimization studies will be performed. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). MediHealth aspires to comprise a successful model promoting considerably researchers competences and long-lasting collaboration between Industry and Academia generating innovation potential at the European and global levels.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2011-IAPP | Award Amount: 2.24M | Year: 2012

NATPROTEC aims to discover and carry to the stage of development innovative products in the area of cosmeceuticals originating from European natural resources using emerging and environmentally friendly technologies. These objectives will be implemented through an extended and balanced scheme of researchers exchanges and recruitments, in both directions and via a mutual scientific project developed on the needs and interests of both Industry and Academia sectors. More specifically, NATPROTEC scientific concept involves the discovery of novel natural products (NPs) originating from the Mediterranean and Alpine biodiversity. Already existing chemical libraries will be exploited incorporating modern high throughput platforms (in silico & in vitro) for the rational and targeted selection of the optimum natural sources. Advanced analytical approaches and techniques will be applied for the efficient, accelerated and advantageous isolation and identification procedures of natural constituents as well as the quality assessment of the lead products. A broad spectrum of bioassays and novel analytical approaches will be incorporated for the evaluation of skin-protecting, anti-ageing and anti-hyperpigmenting activity of all derived products. Attention will be given to the selection of the optimum source of the biomaterial to ensure sustainability and into the development, optimisation and application of novel, green technologies for the production of the final lead products. Within this frame, core scientific knowledge and lead compounds for further development are expected to be produced creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different dynamics and orientation where other skills are required. NATPROTEC aspires to comprise a successful model of an efficient, long-lasting collaboration between Industry and Academia for sustainable exploitation of existing know-how and produced knowledge.


Quantitative nuclear magnetic resonance (qNMR) spectroscopy is known as an excellent alternative to chromatography-based mixture analysis. NMR spectroscopy is a non-destructive method, needs only limited sample preparation, and can be readily automated. A head-to-head comparison of qNMR to an ultra-high-performance liquid chromatography with diode array detection (uHPLC-DAD)-based quantitative analysis of six flavonolignan congeners (silychristin, silydianin, silybin A, silybin B, isosilybin A, and isosilybin B) of the Silybum marianum silymarin complex is presented. Both assays showed similar performance characteristics (linear range, accuracy, precision, and limits of quantitation) with analysis times below 30 min/sample. The assays were applied to industrial S. marianum extracts (AC samples) and to extracts locally prepared from S. marianum fruits (PL samples). An assay comparison by Bland-Altman plots (relative method bias AC samples, -0.1%; 2SD range, 5.1%; relative method bias PL samples, -0.3%; 2SD range, 7.8%) and Passing-Bablok regression analysis (slope and intercept for AC and PL samples not significantly different from 1.00 and 0.00, respectively; Spearmans coefficient of rank correlation, >0.99) did show that qNMR and uHPLC-DAD can be used interchangeably to quantitate flavonolignans in the silymarin complex.


Trademark
Bionorica GmbH | Date: 2012-11-13

Dietary supplements for human consumption; dietary supplements.


Trademark
Bionorica GmbH | Date: 2010-11-02

Essential oils for use in the manufacture of cosmetics, hair lotions and perfumery; hair lotions; dentifrices. Pharmaceutical preparations for use in the treatment, cure, mitigation or prevention of gingivitis, halitosis, stomatitis, periodontitis, inflammation of the oral cavity and pharyngeal cavity, hypersensitivity of teeth, angina, atherosclerosis, bronchial asthma, circulatory disorders, constipation, diarrhea, heart failure, heart rhythm disorders, high blood pressure, indigestion, insomnia, migraine, motion sickness, nausea, peptic ulcers, vomiting, allergy, gynecological disorders affecting menstruation, sterility, menstrual syndromes, dysmenorrhoea, infertility, genital tract infections, pelvic inflammatory diseases, vaginal discomfort due to menopausal atrophic changes, anatomical abnormalities of the head, the extremities, chest, abdomen and organs, neoplasia, breast neoplasm, breast cancer, mastopathy, mastodynia, premenstrual syndrome, climacteric complaints, breast pain, blood conditions and disorders, blood circulation disorders, high blood pressure, hypertension, pulmonary diseases, heart rhythm disorders, heart failure, urological diseases, sexually transmitted diseases and inflammatory pelvic diseases, menopausal complaints due to therapeutically induced menopause, tamoxifen induced hot flushes of breast cancer survivors, climactic sleep disturbances, depressive moods, protection of the skeletal system, osteoporosis, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, psycho vegetative disorders, depressive syndrome, anxiety, nervous unrest, peripheral nervous system infections, peripheral nervous system movement disorders, nerve compression syndromes, neuritis, neuralgia and regional pain syndromes, diseases and disorders of the kidney, urological disorders, chronic infections of the bladder, cystitis, pyelonephritis, glomerulonephritis, interstitial nephritis, nephrolithiasis, cancer, urolith prophylaxis, dizziness, migraine, depression, inflammations of the upper and lower respiratory organs, sinuses, bronchitis, tonsillitis, arthritis, osteoarthritis, fever, cough, cold, Alzheimers disease, infection of respiratory tract, infection of urinary tract, urinary obstruction, chronic venous insufficiency, prostate hyperplasia, muscle pains, soft tissue rheumatism, musculoskeletal disease, liver disease, hepatitis, cirrhosis of liver, periodontal diseases and dental caries; pharmaceutical preparations for use as an antidepressant, diuretic, hypnotic, sedative, analeptic, and tranquilizer; haemorrhoidal ointment, laxative, nasal decongestant capsules, nasal spray preparations, non-narcotic analgesics, throat lozenges; medicinal preparations in tablet form, namely, menstruation circulation regulating tablets; pharmaceutical preparations, namely, for hormone regulation and hormone replacement; pharmaceutical preparations for sensory organs, namely, for use in ophthalmology, otolaryngology and dermatology; pharmaceutical preparations for regulation and strengthening of the immune system, pharmaceutical preparations for treating of and providing temporary relief for occasional minor irritation, pain, sore mouth, sore gums, sore throat, pain associated with canker sores, pain due to minor irritation or injury of the mouth and gums, pain due to minor dental procedures, pain due to minor irritations caused by dentures or orthodontic appliances, sore gums due to teething in infants and children four months of age and older; pharmaceutical products, namely, medicated dental, gum and mouth washes, medicated dental, gum and mouth rinse, medicated toothpastes, medicated oral-care gels, medicated dental gels, medicated lozenges, cough lozenges, medicated chewing gum, medicated gels and fluids in the nature of medicated balms, medicated dental tapes, medicated dental ribbons, medicated dental polish; pharmaceutical preparations for dental purposes, namely, plaque disclosing reagents, periodontal diagnostic reagents for medical purposes for detecting derivatives from periodontal bacteria and caries, diagnostic reagents for detecting derivatives from caries-causing bacteria and medicines for the prevention and treatment of periodontal diseases, dental caries, canker sores, cold sores, mucositis and oral and tongue cancers; medicated mouth sprays, plant extracts for veterinary and pharmaceutical purposes; sanitary preparations for medical use; sanitary preparations for hygiene, namely, antiseptics, oral antiseptics, disinfectants for health purposes; medicated sanitary preparations for the treatment, cleaning and protection of the skin; dietary supplements in the form of tablets, drops, capsules, extract preparations, balms or in liquid form, containing plant extracts; dietetic foods adapted for medical use in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; food for medically restricted diets, food for diabetics, food supplements containing plant extracts, food supplements derived from plants or plant extracts, all aforesaid goods in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; vitamin and mineral supplements; food and food supplements, namely, herbal teas for medicinal purposes and medicinal teas; nutritional additives for use in foods and dietary supplements for human consumption; dietetic food supplements, dietary supplements, food supplements and dietary food supplements; mineral food supplements, food supplements based on amino acids, minerals and/or trace elements, medical plasters; materials for dressings, namely, gauze and bandages; all purpose disinfectants, material for stopping teeth; dental wax. Paper; cardboard; goods made from paper and cardboard, namely, paper bags, coasters, and works of art in the nature of art prints; printed matter, namely, books, magazines, journals, newspapers, periodicals, leaflets, manuals, catalogs and brochures in the fields of health and medicine; printed reviews in the nature of a series of written articles in the fields of health and medicine; bookbinding material, namely, book bindings; photographs; stationery; adhesives for stationery or household purposes; artists materials, namely, artists pastels, artists pencils, artists pens, painting sets for children; paint brushes; typewriters; office requisites except furniture, namely, punches, staplers, erasers, desk pads, pencil sharpeners; instructional and teaching material, namely, printed instructional and teaching material in the field of medicine and phytopharmacy; paper bags, envelopes and pouches for packaging, plastic bags and bubble packs for packaging.


Trademark
Bionorica GmbH | Date: 2011-04-12

Pharmaceutical preparations for use in the treatment, cure, mitigation or prevention of allergies in the form of tablets, drops, capsules, extract preparations, balms, in liquid form or as spray; dietetic supplements for use in the treatment, cure, mitigation or prevention of allergies in the form of tablets, drops, capsules, extract preparations, balms, in liquid form or as spray; dietetic supplements and dietetic food supplements; dietary supplements for human consumption; homeopathic supplements; herbal supplements; food supplements for medical purposes.


Trademark
Bionorica GmbH | Date: 2012-12-11

Printed matter, namely, books, journals, leaflets and brochures in the fields of health and medicine; instructional and teaching material, namely, instructional and teaching materials in the field of medicine and phytopharmacy.


Trademark
Bionorica GmbH | Date: 2011-01-04

[ Chemicals used in industry, namely, raw materials for the manufacture of pharmaceutical preparations ]. [ Essential oils for use in the manufacture of cosmetics; hair lotions; dentifrices ]. Pharmaceutical preparations for use in the treatment, cure, mitigation or prevention of gingivitis, halitosis, stomatitis, periodontitis, inflammation of the oral cavity and pharyngeal cavity, hypersensitivity of teeth, angina, atherosclerosis, bronchial asthma, circulatory disorders, constipation, diarrhoea, heart failure, heart rhythm disorders, high blood pressure, indigestion, insomnia, migraine, motion sickness, nausea, peptic ulcers, vomiting, allergy, gynecological disorders affecting menstruation, sterility, menstrual syndromes, dysmenorrhoea, infertility, genital tract infections, pelvic inflammatory diseases, vaginal discomfort due to menopausal atrophic changes, anatomical abnormalities, neoplasia, breast neoplasm, breast cancer, mamma, mastopathy, mastodynia, premenstrual syndrome, climateric complaints, breast pain, blood conditions and disorders, blood circulation disorders, high blood pressure, hypertension, pulmonary diseases, heart rhythm disorders, heart failure, urological diseases, sexually transmitted diseases and inflammatory pelvic diseases, menopausal complaints due to therapeutically induced menopause, tamoxifen induced hot flushes of breast cancer survivors, vaginal discomfort due to menopausal atrophic changes, climactic sleep disturbances, depressive moods, osteoprotectio, osteoporosis, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders, spinal cord diseases, psycho vegetative disorders, depressive syndrome, anxiety, nervous unrest, peripheral nervous system infections, peripheral nervous system movement disorders, nerve compression syndromes, neuritis, neuralgia and regional pain syndromes, diseases and disorders of the kidney, urological disorders, chronic infections of the bladder, cystitis, pyelonephritis, glomerulonephritis, interstitial nephritis, nephrolithiasis, cancer, urolith prophylaxis, dizziness, migraine, depression, inflammations of the upper and lower respiratory organs, sinuses, bronchitis, tonsillitis, arthritis, osteoarthritis, fever, cough, cold, Alzheimers disease, infection of respiratory tract, infection of urinary tract, urinary obstruction, chronic venous insufficiency, prostate hyperplasia, muscle pains, soft tissue rheumatism, musculoskeletal disease, liver disease, hepatitis, cirrhosis of liver, periodontal diseases and dental caries; pharmaceutical preparations for use as an antidepressant, diuretic, hypnotic, sedative, stimulant, and tranquilizer; hemorrhoidal ointment, laxative, nasal decongestant capsules, nasal spray preparations, non-narcotic analgesics, throat lozenges; menstruation circulation regulating tablets; hormone preparations, hormone replacement medication; pharmaceutical preparations for sensory organs, namely, for use in ophthalmology, otolaryngology and dermatology; pharmaceutical preparations for regulation and strengthening of the immune system; pharmaceutical preparations for treating temporary relief of occasional minor irritation, pain sore mouth, sore gums, sore throat, pain associated with canker sores, pain due to minor irritation or injury of the mouth and gums, pain due to minor dental procedures, pain due to minor irritations caused by dentures or orthodontic appliances, sore gums due to teething in infants and children four months of age and older; pharmaceutical products, namely, medicated dental, gum and mouth washes, medicated dental, gum and mouth rinse, medicated toothpastes, medicated oral-care gels, medicated dental gels, medicated lozenges, cough lozenges, medicated chewing gum, medicated gels and fluids in the nature of dental bleaching gels, gum balms, medicated dental floss, medicated dental tapes, medicated dental ribbons, medicated teeth whitener gels, medicated toothpicks, fluoride chewing gum and chewable tablets for disclosing dental plaque and tartar; preparations for dental purposes, namely, plaque disclosing reagents, periodontal diagnostic reagents for medical purposes for detecting derivatives from periodontal bacteria and caries, diagnostic reagents for detecting derivatives from caries-causal bacteria and medicines for the prevention and treatment of periodontal diseases,dental caries, canker sores, cold sores, mucositis and oral and tongue cancers; medicated mouth sprays and desensitizers; plant extracts for veterinary and pharmaceutical purposes; sanitary preparations for medical use; sanitary preparations for hygiene, namely, antiseptics, oral antiseptics, disinfectants for health purposes; sanitary preparations for the treatment, cleaning and protection of the skin; dietary supplements in the form of tablets, drops, capsules, extract preparations, balms or in liquid form, containing plant extracts; dietetic substances adapted for medical use in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; food for medically restricted diets, food for diabetics, food supplements containing plant extracts, food supplements derived from plants or plant extracts, all aforesaid goods in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; vitamin and mineral supplements; food and food supplements, namely, herbal teas for medicinal purposes and medicinal teas; nutritional additives for use in foods and dietary supplements for human consumption; dietetic food supplements; dietary supplements; food supplements and dietary food supplements; mineral food supplements, food supplements based on amino acids, minerals and/or trace elements; medical plasters; materials for dressings, namely, gauze and bandages; all purpose disinfectants; material for stopping teeth; dental wax. [ Downloadable electronic publications in the nature of magazines, journals, newsletters, periodicals, catalogues, brochures, manuals, leaflets, package inserts in the field of medicine and phytopharmacy, press releases featuring information on medicine and phytopharmacy; prerecorded magnetic data carriers featuring medicine and phytopharmacy; small weighing, measuring, signalling, checking and supervision apparatus, namely, pocket calculators, scales, balances, measuring rules, thermometers, computer storage devices, namely, flash drives, USB flash drives, flash memory cards, memory cards and computer memory hardware all to be used as advertising medium; spectacles, namely, eyeglasses and goggles; protective helmets, namely, bicycle helmets; personal computers; DVD, CD, and magnetic-tape recorders and players ]. [ Paper; cardboard; goods made from paper and cardboard, namely, paper bags, coasters, figures and works of art; printed matter, namely, books, magazines, journals, newspapers, periodicals, leaflets, reviews, manuals, catalogs and brochures in the fields of health and medicine; bookbinding material, namely, bookbindings; photographs; stationery; adhesives for stationery or household purposes; artists materials, namely, artists pastels, artists pencils, artists pens, painting sets for artists; paint brushes; typewriters, office requisites except furniture, namely, punches, staplers, erasers, desk pads, pencil sharpeners; printed instructional and teaching material, namely, instructional and teaching material in the field of medicine and phytopharmacy; paper bags, envelopes and pouches for packaging; plastic bags and bubble packs for packaging ]. [ Household or cooking utensils, namely, graters, sieves, spatulas, strainers, turners, pot and pan scrapers, rolling pins, whisks, skimmers and tongs; containers for household use; cleaning and hair combs; bath, cleaning, and scrub sponges, sponges for household purposes; brushes, namely, cake brushes, clothes brushes, cosmetic brushes, crumb brushes, dishwashing brushes, dusting brushes, electric toothbrushes, floor brushes, hair brushes, nail brushes, shaving brushes, shoe brushes, toilet brushes, tub brushes, and washing brushes; beverage glassware, porcelain mugs and earthenware mugs; dishes made of glass, porcelain and earthenware; figurines, sculptures, statues, statuettes and works of art made of glass, porcelain and earthenware ]. [ Clothing, namely, t-shirts, pants, dresses, jackets, trousers, jumpers, socks; footwear; headgear for men, women and children, namely, hats caps, headscarves ]. [ Games and playthings, namely, board games, card games, dice games, memory games, party games, action skill games, dolls and puppets; positionable toy figures; gymnastic and sporting articles, namely, treadmills, stair machines, stationary exercise bikes, trampolines, skipping ropes, soccer balls, tennis balls, racket balls; rubber balls for games; hockey pucks; rackets for tennis, squash, badminton and table tennis; paddles for use in paddle ball games; decorations for Christmas trees, except lighting apparatus and confectionery ]. [ Food additives for non-medical purposes, namely, food additives containing primarily fatty substances, greases, fatty acids, either singular or in combination, and also containing vitamins, minerals and trace elements; plant extracts for foodstuffs, namely, food additives in the nature of fat acids made from fruits and vegetables; plant extracts for foodstuff in the nature of food additives containing fatty acids and proteins to be used in food supplements and food, namely, soups, powdered nutritional supplement drink mix and porridge; proteins being food additives for human consumption containing fatty substances, fatty acids, vitamins, minerals and trace elements; food additives in the nature of fat acids made from meat, fish, fruits, vegetables, eggs, milk and edible oils and fats containing fatty substances fatty acids, vitamins, minerals and trace elements ]. [ Food additives for non-medical purposes, namely, food additives containing primarily carbohydrates and fiber, and also containing vitamins, minerals and trace elements, either singular or in combination; plant extracts and tinctures not being essential oils in liquid, solid or gaseous form to be used as flavourings in food and nutritional additives; herbal teas for food purposes; food additives in the nature of plant extracts not being essential oils used as flavouring in liquid, solid or gaseous form for foodstuffs, food supplements and food; foods and dietetic foods, namely, ready to eat cereal derived food bars; flavouring additives for non-nutritional purposes in the form of liquids, solids, or gaseous compounds for use in the manufacture of cosmetics and food; herbal teas ]. [ Living plants; dried plants; unprocessed herbs ]. [ Education services, namely, providing classes, courses, seminars, workshops, tutoring and mentoring in the fields of health and medicine; providing of training in the use of medicine and sports equipment ].


Trademark
Bionorica GmbH | Date: 2010-02-23

Plant extracts, namely, extracts from willow bark used in the manufacture of pharmaceutical preparations, bulk pharmaceutical preparations, and raw materials for pharmaceutical preparations. Essential oils. Plant extracts for pharmaceutical preparations, namely, plant extracts for use in the treatment of migraine, motion sickness; plant extracts for pharmaceutical preparations, namely, plant extracts with antidepressant qualities; pharmaceutical preparations for use in the treatment of gingivitis, stomatitis, periodontitis, inflammation of the oral cavity and pharyngeal cavity, angina, migraine, motion sickness, depressive moods, depressive syndrome, neuritis, neuralgia and regional pain syndromes, migraine, depression, inflammations of the upper and lower respiratory organs, sinuses, bronchitis, tonsillitis, arthritis, osteoarthritis, fever, infection of respiratory tract, muscle pains, soft tissue rheumatism, musculoskeletal disease; pharmaceutical preparations made from willow bark, namely, for use in the treatment of migraine, arthritis, osteoarthritis, fever, cough, cold, diarrhea, pain, menstrual syndromes and pain, and Alzheimers disease; pharmaceutical preparations for use as an antidepressant; dietary supplements adapted for medical use in the form of tablets, drops, capsules, extract preparations, balms or in liquid form, containing plant extracts; dietetic substances adapted for medical use in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; food for medically restricted diets, food for diabetics, food supplements containing plant extracts, food supplements derived from plants or plant extracts, all aforesaid goods in the form of tablets, drops, capsules, extract preparations, balms or in liquid form; vitamin and mineral supplements; food and food supplements, namely, herbal teas for medicinal purposes and medicinal teas; nutritional additives for use in foods and dietary supplements for human consumption; dietetic food supplements; dietary supplements; food supplements and dietary food supplements; mineral food supplements, food supplements based on amino acids, minerals and/or trace elements. Living and dried plants.


The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.; and a mixture thereof; or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba; and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.

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