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Cambridge, MA, United States

Strauss S.,Hannover Medical School | Dudziak S.,Laser Zentrum Hannover e.V. | Hagemann R.,Laser Zentrum Hannover e.V. | Barcikowski S.,Laser Zentrum Hannover e.V. | And 8 more authors.

The development of large tissue engineered bone remains a challenge in vitro, therefore the use of hybrid-implants might offer a bridge between tissue engineering and dense metal or ceramic implants. Especially the combination of the pseudoelastic implant material Nitinol (NiTi) with adipose derived stem cells (ASCs) opens new opportunities, as ASCs are able to differentiate osteogenically and therefore enhance osseointegration of implants. Due to limited knowledge about the effects of NiTi-structures manufactured by selective laser melting (SLM) on ASCs the study started with an evaluation of cytocompatibility followed by the investigation of the use of SLM-generated 3-dimensional NiTi-structures preseeded with ASCs as osteoimplant model. In this study we could demonstrate for the first time that osteogenic differentiation of ASCs can be induced by implant-mediated mechanical stimulation without support of osteogenic cell culture media. By use of an innovative implant design and synthesis via SLM-technique we achieved high rates of vital cells, proper osteogenic differentiation and mechanically loadable NiTi-scaffolds could be achieved. © 2012 Strauß et al. Source

Wu G.,University of Vermont | Xue S.,BioMimetics Inc.
IFMBE Proceedings

Advanced age is often associated with an increased risk of accidental falls. Injuries such as hip fractures as a result of accidental falls in the elderly often lead to functional impairment, declined health, and loss of independence [1]. Fall-related hip fractures may be prevented by hip protection pads [2]. However, currently available hip pads are not widely accepted by elders because of cosmetic and comfort reasons [3]. Alternatively, an active protection apparatus - an airbag-based smart hip pad - would provide both an effective protection against the large impact when a fall occurs and the attractive cosmetic look when not sustaining a fall [4, 5]. One of the critical elements of the smart hip pad is the automated fall detection mechanism. The goals of this study were to (1) examine and distinguish the kinematic characteristics of impending falls from those of routine physical activities, and (2) develop a single sensor system to reliably detect falls before the impact occurs. It was hypothesized that the inertial frame vertical velocity near the body center of gravity would be significantly higher during the pre-impact phase of falls than regular daily activities, and that a single inertial sensor would be able to distinguish an in-progress and unrecoverable fall from non-falling activities. © 2010 International Federation for Medical and Biological Engineering. Source

Israelowitz M.,BioMimetics Inc. | Kwon J.-A.,Hillman Cancer Center | Rizvi S.W.H.,BioMimetics Inc. | Gille C.,Charite - Medical University of Berlin | And 2 more authors.
Journal of Bionic Engineering

The Melanophila acuminata beetle is attracted to forest fires via a pair of infrared sensory organs composed of sensilla. Our histological work showed that each sensillum contains lipid layers surrounding a protein layer and a unique polysaccharide base that is associated with a neuron to each sensillum. Infrared microscopy showed that the protein region maximally absorbs infrared radiation at 3 μm wavelength and at 10 μm, which corresponds to the known radiation produced by forest fires at 3 μm. Mathematical calculations showed that the physical properties of the sensilla are such that the expected temperature rise is insufficient for transduction of the infrared signal through mechanical means or as a thermal receptor as previously thought; hence the protein plays the pivotal role in perception of single photons and transmission of the signal within the sensilla. © 2011 Jilin University. Source

Weyand B.,Hannover Medical School | Israelowitz M.,BioMimetics Inc. | Kramer J.,8 Selden Street | Bodmer C.,Habsburger Allee 56 B | And 8 more authors.
BioMed Research International

A three-dimensional computational fluid dynamics-(CFD-) model based on a differential pressure laminar flow bioreactor prototype was developed to further examine performance under changing culture conditions. Cell growth inside scaffolds was simulated by decreasing intrinsic permeability values and led to pressure build-up in the upper culture chamber. Pressure release by an integrated bypass system allowed continuation of culture. The specific shape of the bioreactor culture vessel supported a homogenous flow profile and mass flux at the scaffold level at various scaffold permeabilities. Experimental data showed an increase in oxygen concentration measured inside a collagen scaffold seeded with human mesenchymal stem cells when cultured in the perfusion bioreactor after 24 h compared to static culture in a Petri dish (dynamic: 11% O2 versus static: 3% O2). Computational fluid simulation can support design of bioreactor systems for tissue engineering application. © 2015 Birgit Weyand et al. Source

BioMimetics Inc. and Medizinische Hochschule Hanover | Date: 2011-10-04

The invention provides a process for producing a three-dimensional tissue by cultivating eucaryotic cells by introducing the cells into a matrix and cultivating the cells within the matrix in a cell culture medium within a cell culture vessel under controlled dissolved oxygen conditions of the cell culture medium. The matrix contains a support containing an optical oxygen sensor, which is an oxygen-sensitive dye, which upon irradiation with an excitation wavelength changes its emission characteristics in dependence on the dissolved oxygen concentration in the surrounding medium, including a dye phosphorescing upon irradiation of an excitation wavelength, which phosphorescence is quenched by dissolved oxygen.

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