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News Article | November 15, 2016
Site: www.prnewswire.co.uk

ReportsnReports.com adds "Bladder Cancer - Pipeline Review, H2 2016" to its store, providing comprehensive information on the therapeutics under development for Bladder Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Bladder Cancer and features dormant and discontinued projects. Bladder cancer occurs in tissues of the urinary bladder. Symptoms include blood or blood clots in the urine, frequent urination, lower back pain on one side of the body and burning during urination. Risk factors for bladder cancer include smoking, exposure to substances such as rubber, certain dyes and textiles, paint, and hairdressing supplies, diet rich in fried meats and fat, old age, sex and color, certain parasitic infections. Treatment of bladder cancer includes chemotherapy, surgery, biological therapy and radiation therapy. Complete report on Global Bladder Cancer Market Research with 151 market data tables and 17 figures, spread across 742 pages is available at http://www.reportsnreports.com/reports/747719-bladder-cancer-pipeline-review-h2-2016.html . Company Analysis and Positioning discussed in this research are 4SC AG, Adaptimmune Therapeutics Plc, ADC Therapeutics SA, Agenus Inc, Altor BioScience Corporation, AndroScience Corporation, APIM Therapeutics AS, Arno Therapeutics, Inc., Astellas Pharma Inc., Astex Pharmaceuticals Inc, Aura Biosciences, Inc., AVEO Pharmaceuticals, Inc., Azaya Therapeutics, Inc., Bavarian Nordic A/S, Bayer AG BioCancell Ltd, Biomics Biotechnologies Co., Ltd., Bioncotech Therapeutics SL, Biotest AG, Boehringer Ingelheim GmbH, Bristol-Myers Squibb Company, Celgene Corporation, Cellceutix Corporation, Celldex Therapeutics, Inc., Celprogen, Inc., Celsion Corporation, Codagenix, Inc., Cold Genesys, Inc., Corvus Pharmaceuticals Inc, CytomX Therapeutics, Inc., DormaTarg, Inc., Eisai Co., Ltd., Eleven Biotherapeutics Inc., Eli Lilly and Company, Elsalys Biotech SAS, enGene, Inc, Esperance Pharmaceuticals, Inc., Exelixis, Inc., F. Hoffmann-La Roche Ltd., Five Prime Therapeutics, Inc., Gene Signal International SA, Genmab A/S, GlaxoSmithKline Plc, H3 Biomedicine Inc., Hamlet Pharma AB, Heat Biologics, Inc., HEC Pharm Co., Ltd., Hutchison MediPharma Limited, Idera Pharmaceuticals, Inc., ImmuNext, Inc., Immunocore Limited, Immunomedics, Inc., Immupharma Plc, InteRNA Technologies B.V., Johnson & Johnson, LipoMedix Pharmaceutical Inc., MacroGenics, Inc., MaxiVAX SA, Meabco A/S, Medicenna Therapeutics, Inc., MedImmune LLC, Merck & Co., Inc., Merck KGaA, Mirati Therapeutics Inc., Mirna Therapeutics, Inc., Miyarisan Pharmaceutical Company, Ltd, Moleculin Biotech Inc, NanoCarrier Co., Ltd., Nektar Therapeutics, NuCana BioMed Limited, Omeros Corporation, Oncogenex Pharmaceuticals, Inc., Oncolytics Biotech Inc., OncoTherapy Science, Inc., Ono Pharmaceutical Co., Ltd., Optimum Therapeutics, LLC, Pfizer Inc., Pharma Mar, S.A., Philogen S.p.A., Plexxikon Inc., Polaris Pharmaceuticals, Inc., Provectus Biopharmaceuticals, Inc., PsiOxus Therapeutics Limited, Rexahn Pharmaceuticals, Inc., Rodos BioTarget GmbH, Sanofi, Savoy Pharmaceuticals, Inc., Serometrix, LLC, Shionogi & Co., Ltd., Sillajen Biotherapeutics, Sorrento Therapeutics Inc, Spectrum Pharmaceuticals, Inc., Stemline Therapeutics, Inc., Sun Pharma Advanced Research Co Ltd, Synovo GmbH, Taiwan Liposome Company, Ltd., Tara Immuno-Oncology Therapeutics LLC, Taris Biomedical LLC, Telormedix SA, TesoRx Pharma LLC, Theravectys SA, Theryte Limited, Transgene SA, UroGen Pharmaceuticals, Ltd., Vakzine Projekt Management GmbH, Vault Pharma Inc., Vaxeal Holding SA, Vaxiion Therapeutics, Inc. and Viralytics Ltd. The Bladder Cancer (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Bladder Cancer and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 9, 44, 35, 2, 56 and 12 respectively. Similarly, the Universities portfolio in Phase II, Phase I, Preclinical and Discovery stages comprises 3, 1, 12 and 2 molecules, respectively. Bladder Cancer (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. Connect With Us on:


This invention relates to the application of the highly conserved sequences of viral genome, especially from a highly conserved domain of enteroviral genome as templates to design target small ligand RNAs (sliRNAs). The resulting sliRNAs are therapeutically active ingredients in the treatment of the related diseases caused by pathological angiogenesis.


Patent
BIOMICS BIOTECHNOLOGIES Co. | Date: 2010-03-30

The present invention relates to a modified oligonucleotide, its preparation and application. The invention enables stabilizing the oligonucleotide by introducing a relatively small amount of modified nucleotide at specific UA/UA and/or CA/UG and/or UG/CA site of the oligonucleotide, therefore to decrease the modification-related cytotoxicity and compromising effects on the biological activity.


Patent
Biomics Biotechnologies Co. and Benitec Ltd | Date: 2011-10-27

RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.


Patent
Biomics Biotechnologies Co. | Date: 2013-03-06

The present invention discloses a liposome formulation, its preparation method, and its application in the treatment of diseases caused by abnormal gene expression. The liposome formulation comprises complementary cationic lipid pairs, phospholipids, and long-circulating lipids. The method of preparing the liposome formulation comprises: mixing the complementary cationic lipid pairs with the phospholipid and the long-circulating lipid to generate pre-formed vesicles; and then mixing the pre-formed vesicles with the nucleic acid solution to generate the liposome-nucleic acid formulation. This liposome formulation provided by the present invention is easily prepared; and in the treatment of diseases caused by abnormal gene expression, the liposome formulation can be used to deliver in vivo therapeutic agents, including nucleic acids.


The present invention provides a PCR based high-throughput method for preparing full-sites siRNA polynucleotide pool, comprising: DNase I random digestion; Loop-1 phosphate linker ligation; single PCR amplification; a type III restriction/modification enzyme digestion; blunt ending; Loop-2 phosphate linker ligation; double primer PCR; FokI digestion and cloning into an siRNA expression vector. The present invention enables the use of a type III restriction/modification enzyme linkers mediated PCR method for high-throughput preparing an siRINA polynucleotide pool, in which the functional length of siRNAs can be controllably distributed from 19-23 bp, thus completely mimic the natural siRNA length diversity, specially suitable for RNAi therapeutic targets screening. The present invention overcomes the bottlenecks and drawbacks of conventional siRNA polynucleotide pool construction technologies.


Patent
Biomics Biotechnologies Co. | Date: 2015-07-22

This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.


Patent
Biomics Biotechnologies Co. | Date: 2015-08-14

Long interfering nucleic acid (iNA) duplexes, which are at least 30 nucleotides in length, which have at least one nick or nucleotide gap in the antisense or the sense strands or in both the sense and antisense strands. These long iNA duplexes do not induce an interferon response when transfected into mammalian cells. The antisense strands can target two separate mRNAs or two segments of one mRNA.


Patent
Biomics Biotechnologies Co. | Date: 2012-02-08

The present invention relates to a modified oligonucleotide, its preparation and application. The invention eables stabilizing the oligonucleotide by introducing a relatively small amount of modified nucleotide at specific UA/UA and/or CA/UG and/or UG/CA site of the oligonucleotide, therefore to decrease the modification-related cytotoxicity and compromising effects on the biological activity.


Patent
Biomics Biotechnologies Co. | Date: 2012-03-08

This invention relates to interfering RNA (iRNA) molecules and their applications, especially multi-targets iRNA molecules and their applications. The said multi-targets iRNA molecules comprised of a sense strand annealed onto at least one antisense strand, each strand is at least 30 nucleotides in length, the sense or antisense strand has at least two segments, which can target at least two RNAs of different genes, or can target at least two portions of an RNA, and wherein the iRNA does not induce an interferon-response when transfected into a cell. The iRNA molecule can interfere with the translation procedure post-transcription, and the target gene is inhibited or blocked, the iRNA does not induce an interferon-response in vivo. The RNA molecules are the active ingredient in preparation of the drug which can regulate one or many genes function.

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