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Neuilly-sur-Seine, France

Guettala A.E.-T.,University of Tours | Bouali F.,University of Lille2 | Guinot C.,University of Tours | Guinot C.,Biometrics and Epidemiology Unit | Venturini G.,University of Tours
Proceedings of the International Conference on Information Visualisation | Year: 2012

We deal in this paper with the problem of automating the process of choosing an appropriate visualization and its parameters in the context of visual data mining (VDM). To solve this problem, we develop a user assistant that performs 2 steps: the system starts by suggesting to users different mappings between their data and possible visualizations. This is performed with a simple but generic heuristic that can be applied to any visualization. Then, the user selects a visualization among those proposed by our assistant, and he may further improve the parameters set that defines the mapping between the visual attributes and the data attributes. For this purpose, we use an interactive genetic algorithm (IGA), which allows users to visually evaluate and adjust the mappings. We present a user evaluation that confirms the interest of our system in two tasks. © 2012 IEEE. Source

Elfakir A.,Biometrics and Epidemiology Unit | Ezzedine K.,University of Paris 13 | Ezzedine K.,Bordeaux University Hospital Center | Latreille J.,Biometrics and Epidemiology Unit | And 10 more authors.
Journal of Investigative Dermatology | Year: 2010

The objective of this study was to assess the association between melanocortin-1 receptor (MC1R) variants and the severity of facial skin photoaging. The study population comprised 530 middle-aged French women. A trained dermatologist graded the severity of facial skin photoaging from photographs using a global scale. Logistic regressions were performed to assess the influence of MC1R polymorphisms on severe photoaging with adjustment for possible confounders (demographic and phenotypic data and sun exposure intensity). Among the fifteen MC1R variants identified, the nine most common were V60L, V92M, R151C, R160W, R163Q, R142H, D294H, D84E, and I155T. One hundred and eighty-five individuals (35%) were WT homozygotes, 261 (49%) had one common variant, 78 (15%) had two common variants, and six (1%) had at least one rare variant. After adjustment for possible confounders, the presence of two common variants was already a risk factor for severe photoaging (AOR (95% confidence interval): 2.33 (1.17-4.63)). This risk reached 5.61 (1.43-21.96) when two major diminished-function variants were present. Surprisingly, the minor variant, V92M, was associated with increased risk of photoaging (2.57 (1.23-5.35)). Our results suggest that genetic variations of MC1R are important determinants for severe photoaging. © 2010 The Society for Investigative Dermatology. Source

Latreille J.,Biometrics and Epidemiology Unit | Levy J.-L.,Center Laser Dermatologique | Guinot C.,Biometrics and Epidemiology Unit | Guinot C.,University of Tours
Journal of the European Academy of Dermatology and Venereology | Year: 2011

Background Despite increasing demands for decorative tattooing in people of all ages, occupations and social classes, little is known regarding individuals' characteristics and behaviour with respect to tattooing. Objective The objective was to describe a large sample of French people asking for tattoo laser removal, to investigate their reasons for being tattooed and for tattoo removal, and to identify groups of subjects sharing similar characteristics. Methods A prospective exploratory study was conducted on 151 consecutive subjects asking for tattoo removal. Results The study population was composed of 65 women and 86 men, aged between 18 and 60 years. The reasons mentioned for tattoo removal included aesthetic, social, employment, family or partner pressure, change of lifestyle or partner and incompatibility with present attitudes and values. Four profiles were identified. Types 1 and 3 correspond to subjects with amateur tattoos more frequently reporting social reasons for tattoo removal, whereas types 2 and 4 correspond to subjects with studio tattoos who more frequently report aesthetic reasons. Types 1 and 4 are mainly composed of men (aged over forty and under forty, respectively), type 2 of women under thirty and type 3 of subjects of either sex aged over forty. Conclusions These profiles could be used to target information campaigns about tattooing and tattoo removal techniques to avoid unwanted tattoos, and afterwards, possible disappointment after removal, as well as to target education programs on possible health risks. Furthermore, our findings open the way to focus further studies on more homogenous group of tattooed subjects. © 2010 European Academy of Dermatology and Venereology. Source

Ezzedine K.,Bordeaux University Hospital Center | Ezzedine K.,French Institute of Health and Medical Research | Latreille J.,French Institute of Health and Medical Research | Latreille J.,Biometrics and Epidemiology Unit | And 7 more authors.
European Journal of Cancer | Year: 2010

Context: In the SU.VI.MAX study, antioxidant supplementation for 7.5 years was found to increase skin cancer risk in women but not in men. Objective: To investigate the potential residual or delayed effect of antioxidant supplementation on skin cancer incidence after a 5-year post-intervention follow-up. Design, setting and participants: Assessment of skin cancer including melanoma and non-melanoma during the post-intervention follow-up (September 2002-August 2007). The SU.VI.MAX study was a double-blind, placebo-controlled, randomised trial, in which 12,741 French adults (7713 women aged 35-60 years and 5028 men aged 45-60 years) received daily a placebo or a combination of ascorbic acid (120 mg), vitamin E (30 mg), β-carotene (6 mg), selenium (100 μg) and zinc (20 mg), from inclusion in 1994 to September 2002. Main outcome measures: Total skin cancer incidence, including melanoma, squamous cell carcinoma and basal cell carcinoma. Results: During the post-intervention period, 10 melanomas appeared in women and 9 in men (26 and 18, respectively, for the total period of supplementation + post-supplementation). Six squamous cell carcinomas were found in women and 15 in men (10 and 25, respectively, for the total period). Finally, 40 basal cell carcinomas appeared in women and 36 in men (98 and 94, respectively, for the total period). Regarding potential residual or delayed effects of supplementation in women, no increased risk of melanoma was observed during the post-intervention follow-up period. No delayed effects, either on melanoma or non-melanoma skin cancers, were observed for either gender. Conclusions: The risk of skin cancers associated with antioxidant intake declines following interruption of supplementation. This supports a causative role for antioxidants in the evolution of skin cancers. © 2010 Elsevier Ltd. All rights reserved. Source

Guinot C.,Biometrics and Epidemiology Unit | Guinot C.,University of Tours | Cheffai S.,Ho Pital Militaire Principal dInstruction de Tunis | Latreille J.,Biometrics and Epidemiology Unit | And 5 more authors.
Journal of the European Academy of Dermatology and Venereology | Year: 2010

Background Melasma is a frequent cause of consultations at dermatology departments by dark-skinned patients in Tunisia. Objective To investigate factors that influence melasma severity in a large Tunisian population. Methods A total of 197 patients (188 women and 9 men), who attended Tunis Military Hospital for a consultation were included prospectively from August 2005 to August 2006. Disease severity was estimated using the Melasma Area and Severity Index (MASI). Aggravating factors were investigated using multiple logistic regressions. Results Of the women included, 14% presented phototype III, 45% phototype IV and 41% phototype V; 76% presented a centrofacial melasma phenotype, 23% a malar and 1% a mandibular phenotype. About 60% developed melasma before thirty. Sun exposure was reported as a triggering factor by 51% of women and as an aggravating factor by 84%. Pregnancy was reported as an aggravating factor by 51% of women who had been pregnant, and oral contraceptive use reported by 38% of women exposed to oral contraceptives. The risk of severe melasma was about three times higher for women with age at onset under 30, phototype V and major lifetime sun exposure and about 8 times higher for women exposed to oral contraceptives. Conclusion This study identifies a number of factors associated with the severity of melasma. Further epidemiological studies in this type of population, in particular, to investigate triggering factors, are justified by the aesthetic damage caused by melasma in dark-skinned patients, lack of efficacy of existing treatments, non-compliance with photoprotection recommendations and the challenge of treatment. © 2010 The Authors. Source

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