PubMed | 4 Biometric Research Branch, New York University and National Cancer Center
Type: Journal Article | Journal: The British journal of radiology | Year: 2016
To evaluate the associations between intravoxel incoherent motion (IVIM)-derived parameters and histopathological features and subtypes of breast cancer.Pre-operative MRI from 275 patients with unilateral breast cancer was analyzed. The apparent diffusion coefficient (ADC) and IVIM parameters [tissue diffusion coefficient (Dt), perfusion fraction (fp) and pseudodiffusion coefficient] were obtained from cancer and normal tissue using diffusion-weighted imaging with b-values of 0, 30, 70, 100, 150, 200, 300, 400, 500 and 800smm(-2). We then compared the IVIM parameters of tumours with different histopathological features and subtypes.The ADC and Dt were lower and fp was higher in cancers than in normal tissues (p<0.001). The Dt was lower in high Ki-67 cancer than in low Ki-67 cancer (p=0.019), whereas ADC showed no significant difference (p=0.309). Luminal B [human epidermal growth factor receptor 2 (HER2)-negative] cancer showed lower ADC (p=0.003) and Dt (p=0.001) than other types.We found low tissue diffusivity in high Ki-67 cancer and luminal B (HER2-negative) cancer using IVIM imaging.Low tissue diffusivity is more clearly shown in high Ki-67 tumours and luminal B (HER2-negative) tumours with the IVIM model.