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Koh H.S.,National University of Singapore | Yong T.,National University of Singapore | Teo W.E.,National University of Singapore | Teo W.E.,Biomers Pte Ltd | And 7 more authors.
Journal of Neural Engineering | Year: 2010

A novel nanofibrous construct for promoting peripheral nerve repair was fabricated and tested in a rat sciatic nerve defect model. The conduit is made out of bilayered nanofibrous membranes with the nanofibers longitudinally aligned in the lumen and randomly oriented on the outer surface. The intra-luminal guidance channel is made out of aligned nanofibrous yarns. In addition, biomolecules such as laminin and nerve growth factor were incorporated in the nanofibrous nerve construct to determine their efficacy in in vivo nerve regeneration. Muscle reinnervation, withdrawal reflex latency, histological, axon density and electrophysiology tests were carried out to compare the efficacy of nanofibrous constructs with an autograft. Our study showed mixed results when comparing the artificial constructs with an autograft. In some cases, the nanofibrous conduit with aligned nanofibrous yarn as an intra-luminal guidance channel performs better than the autograft in muscle reinnervation and withdrawal reflex latency tests. However, the axon density count is highest in the autograft at mid-graft. Functional recovery was improved with the use of the nerve construct which suggested that this nerve implant has the potential for clinical usage in reconstructing peripheral nerve defects. © 2010 IOP Publishing Ltd.

Teo W.E.,National University of Singapore | Teo W.E.,Biomers Pte Ltd | Liao S.,Nanyang Technological University | Chan C.,National University of Singapore | And 2 more authors.
Acta Biomaterialia | Year: 2011

Two different techniques were used to fabricate nanoparticle-reinforced nanofibrous scaffolds with different organizations of the minerals. First, a three-dimensional (3D) cylindrical nanofibrous scaffold made of poly-l-lactide and poly(l-lactide)/collagen (1:1) was fabricated using a modified electrospinning method. An alternating dipping method and a flow version of it were used to mineralize the 3D scaffolds. Flow mineralization was found to significantly improve the distribution of the mineral nanoparticles throughout the 3D nanofibrous scaffold, while mineral nanoparticles were found only on the periphery of the static mineralized scaffold. As a result of the mineral nanoparticle distribution, the compressive strength and modulus of the flow mineralized scaffold was found to be significantly greater than that of the static mineralized scaffold, despite having a lower mineral content. Energy-dispersive X-ray analysis and X-ray diffraction studies suggest that the mineral was composed of heterogeneous phases of calcium phosphates. This study demonstrates the importance of hierarchical and deliberate organization of the nanocomponents to optimize the mechanical properties, as is often found in nature. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Biomers Pte Ltd | Date: 2011-05-10

Orthodontic appliances.

Biomers Pte. Ltd. and Biomers Products LLC | Date: 2008-12-23

Orthodontic appliances.

A method for design of a series of custom composite orthodontic wires comprises collecting data about an initial teeth configuration of a patient and generating a tooth movement plan. The tooth movement plan comprises determining both a bracket mounting location for each bracket on a corresponding tooth and a number of stages, including an initial stage, determining movement of teeth from the initial teeth configuration to a final teeth configuration, and determining the custom composite orthodontic wire for each stage of the number of stages. The custom composite orthodontic wire used at the initial stage has at least one multidimensional bend. The custom composite orthodontic appliance for moving teeth is implemented by attaching brackets at the bracket mounting location for each bracket on a corresponding tooth, and connecting the brackets with the custom composite archwire.

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