Biomers Pte Ltd

Singapore

Biomers Pte Ltd

Singapore

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Kaur S.,National University of Singapore | Kaur S.,University of Ottawa | Kaur S.,BioMers Pte. Ltd | Sundarrajan S.,National University of Singapore | And 7 more authors.
Journal of Materials Science | Year: 2014

Electrospun nanofibrous membranes (ENMs) are used in a variety of applications, including sensors, tissue engineering, air filtration, energy, and reinforcement in composite materials. Recently, they have gained an interest in the field of liquid filtration. The membranes, surface, bulk, and overall architecture play an important role in the filtration properties and hence the right characterization technique needs to be established, which will pave the way for future developments in the field of filtration. In this article, we have reviewed the recent advances in ENMs for liquid separation application. © 2014 Springer Science+Business Media New York.


Panneerselvan A.,National University of Singapore | Nguyen L.T.,National University of Singapore | Su Y.,Donghua University | Teo W.E.,Biomers Pte Ltd | And 4 more authors.
Journal of Tissue Engineering and Regenerative Medicine | Year: 2015

An implantable scaffold pre-seeded with cells needs to remain viable and encourage rapid angiogenesis in order to replace injured tissues, especially for tissue defect repairs. We created a bioartificial adipose graft composed of an electrospun 3D nanofibrous scaffold and fat tissue excised from New Zealand white rabbits. Cell viability and angiogenesis potential of the bioartificial substitute were examined during four weeks of culture in Dulbecco's Modified Eagle Medium by immunohistochemical staining with LIVE/DEAD® cell kit and PECAM-1 antibody, respectively. In addition, a Matrigel® assay was performed to examine the possibility of blood vessels sprouting from the bioartificial graft. Our results showed that cells within the graft were viable and vascular tubes were present at week 4, while cells in a fat tissue block were dead in vitro. In addition, capillaries were observed sprouting from the graft into the Matrigel, demonstrating its angiogenic potential. We expect that improved cell viability and angiogenesis in the bioartificial substitute, compared to intact autologous graft, could potentially contribute to its survival following implantation. © 2012 John Wiley & Sons, Ltd.


Teo W.-E.,National University of Singapore | Teo W.-E.,Biomers Pte Ltd | Inai R.,MECC Co. | Ramakrishna S.,National University of Singapore | Ramakrishna S.,King Saud University
Science and Technology of Advanced Materials | Year: 2011

Progress in the electrospinning techniques has brought new methods for the production and construction of various nanofibrous assemblies. The parameters affecting electrospinning include electrical charges on the emerging jet, charge density and removal, as well as effects of external perturbations. The solvent and the method of fiber collection also affect the construction of the final nanofibrous architecture. Various techniques of yarn spinning using solid and liquid surfaces as well as surface-free collection are described and compared in this review. Recent advances allow production of 3D nanofibrous scaffolds with a desired microstructure. In the area of tissue regeneration and bioengineering, 3D scaffolds should bring nanofibrous technology closer to clinical applications. There is sufficient understanding of the electrospinning process and experimental results to suggest that precision electrospinning is a real possibility. © 2011 National Institute for Materials Science.


Koh H.S.,National University of Singapore | Yong T.,National University of Singapore | Teo W.E.,National University of Singapore | Teo W.E.,Biomers Pte. Ltd. | And 7 more authors.
Journal of Neural Engineering | Year: 2010

A novel nanofibrous construct for promoting peripheral nerve repair was fabricated and tested in a rat sciatic nerve defect model. The conduit is made out of bilayered nanofibrous membranes with the nanofibers longitudinally aligned in the lumen and randomly oriented on the outer surface. The intra-luminal guidance channel is made out of aligned nanofibrous yarns. In addition, biomolecules such as laminin and nerve growth factor were incorporated in the nanofibrous nerve construct to determine their efficacy in in vivo nerve regeneration. Muscle reinnervation, withdrawal reflex latency, histological, axon density and electrophysiology tests were carried out to compare the efficacy of nanofibrous constructs with an autograft. Our study showed mixed results when comparing the artificial constructs with an autograft. In some cases, the nanofibrous conduit with aligned nanofibrous yarn as an intra-luminal guidance channel performs better than the autograft in muscle reinnervation and withdrawal reflex latency tests. However, the axon density count is highest in the autograft at mid-graft. Functional recovery was improved with the use of the nerve construct which suggested that this nerve implant has the potential for clinical usage in reconstructing peripheral nerve defects. © 2010 IOP Publishing Ltd.


Teo W.E.,National University of Singapore | Teo W.E.,Biomers Pte Ltd. | Liao S.,Nanyang Technological University | Chan C.,National University of Singapore | And 2 more authors.
Acta Biomaterialia | Year: 2011

Two different techniques were used to fabricate nanoparticle-reinforced nanofibrous scaffolds with different organizations of the minerals. First, a three-dimensional (3D) cylindrical nanofibrous scaffold made of poly-l-lactide and poly(l-lactide)/collagen (1:1) was fabricated using a modified electrospinning method. An alternating dipping method and a flow version of it were used to mineralize the 3D scaffolds. Flow mineralization was found to significantly improve the distribution of the mineral nanoparticles throughout the 3D nanofibrous scaffold, while mineral nanoparticles were found only on the periphery of the static mineralized scaffold. As a result of the mineral nanoparticle distribution, the compressive strength and modulus of the flow mineralized scaffold was found to be significantly greater than that of the static mineralized scaffold, despite having a lower mineral content. Energy-dispersive X-ray analysis and X-ray diffraction studies suggest that the mineral was composed of heterogeneous phases of calcium phosphates. This study demonstrates the importance of hierarchical and deliberate organization of the nanocomponents to optimize the mechanical properties, as is often found in nature. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


PubMed | Biomers Pte Ltd, National University of Singapore, Nanyang Technological University and Donghua University
Type: Journal Article | Journal: Journal of tissue engineering and regenerative medicine | Year: 2015

An implantable scaffold pre-seeded with cells needs to remain viable and encourage rapid angiogenesis in order to replace injured tissues, especially for tissue defect repairs. We created a bioartificial adipose graft composed of an electrospun 3D nanofibrous scaffold and fat tissue excised from New Zealand white rabbits. Cell viability and angiogenesis potential of the bioartificial substitute were examined during four weeks of culture in Dulbeccos Modified Eagle Medium by immunohistochemical staining with LIVE/DEAD cell kit and PECAM-1 antibody, respectively. In addition, a Matrigel assay was performed to examine the possibility of blood vessels sprouting from the bioartificial graft. Our results showed that cells within the graft were viable and vascular tubes were present at week 4, while cells in a fat tissue block were dead in vitro. In addition, capillaries were observed sprouting from the graft into the Matrigel, demonstrating its angiogenic potential. We expect that improved cell viability and angiogenesis in the bioartificial substitute, compared to intact autologous graft, could potentially contribute to its survival following implantation.


A method for design of a series of custom composite orthodontic wires comprises collecting data about an initial teeth configuration of a patient and generating a tooth movement plan. The tooth movement plan comprises determining both a bracket mounting location for each bracket on a corresponding tooth and a number of stages, including an initial stage, determining movement of teeth from the initial teeth configuration to a final teeth configuration, and determining the custom composite orthodontic wire for each stage of the number of stages. The custom composite orthodontic wire used at the initial stage has at least one multidimensional bend. The custom composite orthodontic appliance for moving teeth is implemented by attaching brackets at the bracket mounting location for each bracket on a corresponding tooth, and connecting the brackets with the custom composite archwire.


Trademark
Biomers Pte Ltd. | Date: 2013-01-08

Orthodontic appliances.


Trademark
Biomers Pte Ltd | Date: 2011-05-10

Orthodontic appliances.

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