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Richland Center, WI, United States

Allen K.P.,Biomedical Resource Center | Csida T.,Biomedical Resource Center | Leming J.,Biomedical Resource Center | Murray K.,Biomedical Resource Center | And 2 more authors.
Lab Animal

Although the amounts of money and time associated with using shoe covers or other means to prevent floor contamination in animal research facilities can be substantial, the most effective policies and practices remain unknown. In this study, the authors subjected six occupied rodent holding rooms in their animal research facility to three conditions: use of disinfectant mats; use of shoe covers; and no disinfectant mats or shoe covers. The authors took bacterial culture samples from the rooms under each condition. There was no significant difference in the mean number of colony forming units (CFUs) cultured when the disinfectant mats or shoe covers were used. However, the mean number of CFUs obtained was significantly lower when either disinfectant mats or shoe covers were used than when neither was used. These results suggest that using disinfectant mats or disposable shoe covers may reduce the bacterial load on rodent holding room floors. Source

Allen K.P.,Biomedical Resource Center | Allen K.P.,Medical College of Wisconsin | Dwinell M.R.,Medical College of Wisconsin | Zappa A.M.,Medical College of Wisconsin | And 4 more authors.
Journal of the American Association for Laboratory Animal Science

The cage floor space recommended for a female rat with a litter is greater in the 8th edition of the Guide for the Care and Use of Laboratory Animals than in previous editions. As a result, research institutions using commonly available cages to house rats may not offer the recommended amount of space for a breeDing pair and litter housed in the same cage. We evaluated breeDing parameters in rats housed in cages with 143 in2 (922.6 cm2) compared with 210 in2 (1355 cm2) of floor space. Given the strains of rats typically used at our institution, a monogamous breeDing pair and litter requires 164 in2 (1058.1 cm2) of floor space accorDing to the Guide. Pairs of breeDing animals were housed in each type of cage; and average time between litters, number of litters born, percentage of litter weaned, numbers of pups born and weaned, and average weaning weights were evaluated. None of the breeDing parameters evaluated differed accorDing to the floor space of the cage in which the rats were housed. Source

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