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Oliveras A.,Hospital Universitari del Mar | Oliveras A.,IMIM Hospital del Mar Medical Research Institute | Segura J.,Hospital 12 Of Octubre | Suarez C.,Hospital La Princesa | And 9 more authors.
Journal of Human Hypertension | Year: 2016

Arterial stiffness as assessed by carotid-femoral pulse wave velocity (cfPWV) is a marker of preclinical organ damage and a predictor of cardiovascular outcomes, independently of blood pressure (BP). However, limited evidence exists on the association between long-term variation (Δ) on aortic BP (aoBP) and ΔcfPWV. We aimed to evaluate the relationship of ΔBP with ΔcfPWV over time, as assessed by office and 24-h ambulatory peripheral BP, and aoBP. AoBP and cfPWV were evaluated in 209 hypertensive patients with either diabetes or metabolic syndrome by applanation tonometry (Sphygmocor) at baseline(b) and at 12 months of follow-up(fu). Peripheral BP was also determined by using validated oscillometric devices (office(o)-BP) and on an outpatient basis by using a validated (Spacelabs-90207) device (24-h ambulatory BP). ΔcfPWV over time was calculated as follows: ΔcfPWV = [(cfPWVfu-cfPWVb)/cfPWVb] × 100. ΔBP over time resulted from the same formula applied to BP values obtained with the three different measurement techniques. Correlations (Spearman 'Rho') between ΔBP and ΔcfPWV were calculated. Mean age was 62 years, 39% were female and 80% had type 2 diabetes. Baseline office brachial BP (mm Hg) was 143±20/82±12. Follow-up (12 months later) office brachial BP (mm Hg) was 136±20/79±12. ΔcfPWV correlated with ΔoSBP (Rho=0.212; P=0.002), Δ24-h SBP (Rho=0.254; P<0.001), Δdaytime SBP (Rho=0.232; P=0.001), Δnighttime SBP (Rho=0.320; P<0.001) and ΔaoSBP (Rho=0.320; P<0.001). A multiple linear regression analysis included the following independent variables: ΔoSBP, Δ24-h SBP, Δdaytime SBP, Δnighttime SBP and ΔaoSBP. ΔcfPWV was independently associated with Δ24-h SBP (β-coefficient=0.195; P=0.012) and ΔaoSBP (β-coefficient= 0.185; P=0.018). We conclude that changes in both 24-h SBP and aoSBP more accurately reflect changes in arterial stiffness than do office BP measurements. © 2016 Macmillan Publishers Limited All rights reserved.


PubMed | University of Barcelona, Hospital La Princesa, Hospital Clinico San Carlos, IBSAL Institute of Biomedical Research of Salamanca and 3 more.
Type: Journal Article | Journal: Journal of human hypertension | Year: 2016

Arterial stiffness as assessed by carotid-femoral pulse wave velocity (cfPWV) is a marker of preclinical organ damage and a predictor of cardiovascular outcomes, independently of blood pressure (BP). However, limited evidence exists on the association between long-term variation () on aortic BP (aoBP) and cfPWV. We aimed to evaluate the relationship of BP with cfPWV over time, as assessed by office and 24-h ambulatory peripheral BP, and aoBP. AoBP and cfPWV were evaluated in 209 hypertensive patients with either diabetes or metabolic syndrome by applanation tonometry (Sphygmocor) at baseline(b) and at 12 months of follow-up(fu). Peripheral BP was also determined by using validated oscillometric devices (office(o)-BP) and on an outpatient basis by using a validated (Spacelabs-90207) device (24-h ambulatory BP). cfPWV over time was calculated as follows: cfPWV=[(cfPWVfu-cfPWVb)/cfPWVb] 100. BP over time resulted from the same formula applied to BP values obtained with the three different measurement techniques. Correlations (Spearman Rho) between BP and cfPWV were calculated. Mean age was 62 years, 39% were female and 80% had type 2 diabetes. Baseline office brachial BP (mmHg) was 14320/8212. Follow-up (12 months later) office brachial BP (mmHg) was 13620/7912. cfPWV correlated with oSBP (Rho=0.212; P=0.002), 24-h SBP (Rho=0.254; P<0.001), daytime SBP (Rho=0.232; P=0.001), nighttime SBP (Rho=0.320; P<0.001) and aoSBP (Rho=0.320; P<0.001). A multiple linear regression analysis included the following independent variables: oSBP, 24-h SBP, daytime SBP, nighttime SBP and aoSBP. cfPWV was independently associated with 24-h SBP (-coefficient=0.195; P=0.012) and aoSBP (-coefficient= 0.185; P=0.018). We conclude that changes in both 24-h SBP and aoSBP more accurately reflect changes in arterial stiffness than do office BP measurements.

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