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Owida A.,Swinburne University of Technology | Owida A.,Biomechanics and Tissue Engineering Group | Chen R.,Donghua University | Patel S.,Swinburne University of Technology | And 2 more authors.
Rapid Prototyping Journal | Year: 2011

Purpose - The purpose of this paper is to prepare a new combined method of rapid prototyping, fused deposition modeling (FDM) and electrospinning for the fabrication of coronary artery bypass graft (CABG). Design/methodology/approach - A dynamically optimum design of blood vessel graft was constructed using FDM and electrospinning. Fabrication of 3-D CABG model was constructed using pro-engineer based on the optimum hemodynamic analysis and was converted to an stereolithography file format which was imported to the Magic software where it was edited to a high-resolution contour. The model was then created from acrylonitrile butadiene styrene which was used as a collector for electrospinning fabrication. For the electrospinning thermoplastic polyurethane was dissolved with hexafluoroisopropanol. The voltage applied for electrospinning was 15 kV where the solid FDM model was used to collect nanofibers at fixed distance. Findings - The properties of the fabricated vessel agreed well with those of human artery. The proposed method can be effectively used for the fabrication of an optimized graft design. This proposed method has been proved as a promising fabrication processes in fabricating a specially designed graft with the correct physical and mechanical properties. Originality/value - The proposed method is novel and combines the advantages of both FDM and electrospinning techniques. © Emerald Group Publishing Limited.


Labay C.,Polytechnic University of Catalonia | Labay C.,Biomechanics and Tissue Engineering Group | Canal J.M.,Polytechnic University of Catalonia | Modic M.,Jozef Stefan Institute | And 6 more authors.
Biomaterials | Year: 2015

Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success. © 2015 Elsevier Ltd.


PubMed | Biomechanics and Tissue Engineering Group, Jozef Stefan Institute, University of Barcelona, Autonomous University of Barcelona and Polytechnic University of Catalonia
Type: | Journal: Biomaterials | Year: 2015

Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success.


Labay C.,Polytechnic University of Catalonia | Canal J.M.,Polytechnic University of Catalonia | Navarro A.,Polytechnic University of Catalonia | Canal C.,Biomechanics and Tissue Engineering Group | Canal C.,CIBER ISCIII
Applied Surface Science | Year: 2014

Cosmetic and medical applications of technical textiles are a research expanding field. One of the added values of these new materials would be that they are suitable to contain and release active ingredients in a controlled manner. The influence of the initial state of the surface of polyamide 6.6 (PA66) fibers on the wetting properties of the fibers as well as on the incorporation of caffeine on the fibers and on its release kinetics from the fibers has been investigated. Comparison between industrially-finished PA66 fabrics and laboratory washed fabrics has been done to carry out this study. Furthermore, surface modification of the PA66 fibers by low temperature plasma has been studied regarding the modification of the physical, chemical and topographical properties of the textile fibers. Corona plasma treatment has been investigated to achieve surface modification in the first nanometers of polymer fibers surface in order to modulate the incorporation and the release of caffeine. It has been demonstrated that both initial state of the PA66 surface and prior plasma treatment of the PA66 fibers before the active principle incorporation condition caffeine release kinetics from the textile fibers. The final release percentage increases linearly with the C-O and CO functional groups incorporated by plasma on the surface. It has also been established that the release amounts of caffeine achieved after 8 h from the PA66 fabric are in the same order of magnitude than topical doses of commercial gel-based formulations. © 2014 Elsevier B.V. All rights reserved.


Montufar E.B.,Biomechanics and Tissue Engineering Group | Montufar E.B.,CIBER ISCIII | Traykova T.,Biomechanics and Tissue Engineering Group | Gil C.,Biomechanics and Tissue Engineering Group | And 13 more authors.
Acta Biomaterialia | Year: 2010

The application of minimally invasive surgical techniques in the field of orthopaedic surgery has created a growing need for new injectable synthetic materials that can be used for bone grafting. In this work a novel fully synthetic injectable calcium phosphate foam was developed by mixing α-tricalcium phosphate (α-TCP) powder with a foamed polysorbate 80 solution. Polysorbate 80 is a non-ionic surfactant approved for parenteral applications. The foam was able to retain the porous structure after injection provided that the foamed paste was injected shortly after mixing (typically 2.5 min), and set through the hydrolysis of α-TCP to a calcium-deficient hydroxyapatite, thus producing a hydroxyapatite solid foam in situ. The effect of different processing parameters on the porosity, microstructure, injectability and mechanical properties of the hydroxyapatite foams was analysed, and the ability of the pre-set foam to support osteoblastic-like cell proliferation and differentiation was assessed. Interestingly, the concentration of surfactant needed to obtain the foams was lower than that considered safe in drug formulations for parenteral administration. The possibility of combining bioactivity, injectability, macroporosity and self-setting ability in a single fully synthetic material represents a step forward in the design of new materials for bone regeneration compatible with minimally invasive surgical techniques. © 2009 Acta Materialia Inc.


Labay C.,Polytechnic University of Catalonia | Canal J.M.,Polytechnic University of Catalonia | Canal C.,Biomechanics and Tissue Engineering Group | Canal C.,CIBER ISCIII
Plasma Processes and Polymers | Year: 2012

Polymer fabrics are used in different areas of pharmaceutical technology as sanitary materials or implants, which make them an interesting support for drug delivery. Low pressure plasma allows modifying the first nanometers on the surface of polymers without altering their bulk properties. The aim of the present work was to evaluate the use of plasma technology as an efficient tool to modify polyamide 6.6 fibers and its relevance on the incorporation and release of an active principle, in this case caffeine, from the materials. Therefore, surface modification of polyamide 6.6 (PA 66) fiber properties (wettability, chemical, and topographical properties) was evaluated under different plasma working conditions. It was shown that the thickness of a PDMS coating layer on the fibers was reduced as a function of plasma working conditions (increased air flow rate), and that surface functionalization of polyamide took place by oxygen-containing moieties without any degradation or alteration in fiber topography. In vitro caffeine release showed that plasma gas flow increase improves significantly (up to 90% after 24 h) the delivery of active principle from the fabrics without altering the release mechanism from the PA 66 fabrics. Plasma technology was evaluated as a tool to modify polyamide 6.6 fibers and its relevance on the incorporation and release of an active principle. In vitro caffeine release showed that plasma gas flow increase improved significantly (up to 90% after 24 h) the delivery of active principle from the fabrics without altering the release mechanism from the fabrics. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Patino A.,Polytechnic University of Catalonia | Canal C.,Biomechanics and Tissue Engineering Group | Rodriguez C.,Polytechnic University of Catalonia | Caballero G.,Polytechnic University of Catalonia | And 2 more authors.
Cellulose | Year: 2011

The surface of cotton fabrics was functionalized through corona plasma treatments and/or by cationising the whole of the fibre with an epihalohydrin. The effects of both treatments, individually and in combination are analyzed through wettability studies, by X-ray photoelectron spectroscopy (XPS), Scanning electron microscopy (SEM), and also by dyeing studies with an hetero bis functional reactive dye. Plasma improved wetting properties, exhaustion of the dyebaths and K/Scorr of the fabrics through surface functionalisation. Cationising of the cotton highly increased the exhaustion of the dyebaths and produced a dramatic improvement in K/Scorr. Plasma treatment previous to cationising increased the impregnation of the fabrics, but the effects of both treatments on dyeing parameters are additive only in column water rise and generally the effects obtained by cationising with the epihalohydrin prevail. The differences between both treatments are discussed in terms of surface functionalisation of the cotton fibres. © 2011 Springer Science+Business Media B.V.


Labay C.,Polytechnic University of Catalonia | Canal C.,Biomechanics and Tissue Engineering Group | Canal C.,CIBER ISCIII | Rodriguez C.,Polytechnic University of Catalonia | And 2 more authors.
Applied Surface Science | Year: 2013

Fiber surface modification with air corona plasma has been studied through dyeing kinetics under isothermal conditions at 30 C on an acrylic-fiber fabric with a cationic dye (CI Basic Blue 3) analyzing the absorption, desorption and fixing on the surface of molecules having defined cationic character. The initial dyeing rate in the first 60 s indicates an increase of 58.3% in the dyeing rate due to the effect of corona plasma on the acrylic fiber surface. At the end of the dyeing process, the plasma-treated fabrics absorb 24.7% more dye, and the K/S value of the acrylic fabric increases by 8.8%. With selected dyestuff molecules, new techniques can be designed to amplify the knowledge about plasma-treated surface modifications of macromolecules. © 2013 Elsevier B.V. All rights reserved.


Labay C.,University of Barcelona | Labay C.,Center for Research in NanoEngineering n | Buxadera-Palomero J.,University of Barcelona | Buxadera-Palomero J.,Center for Research in NanoEngineering n | And 8 more authors.
Journal of Physics D: Applied Physics | Year: 2016

Beta-tricalcium phosphate (β-TCP) bioceramics are employed in bone repair surgery. Their local implantation in bone defects puts them in the limelight as potential materials for local drug delivery. However, obtaining suitable release patterns fitting the required therapeutics is a challenge. Here, plasma polymerization of ampicillin-loaded β-TCP is studied for the design of a novel antibiotic delivery system. Polyethylene glycol-like (PEG-like) coating of β-TCP by low pressure plasma polymerization was performed using diglyme as precursor, and nanometric PEG-like layers were obtained by simple and double plasma polymerization processes. A significant increase in hydrophobicity, and the presence of plasma polymer was visible on the surface by SEM and quantified by XPS. As a main consequence of the plasma polymerisation, the release kinetics were successfully modified, avoiding burst release, and slowing down the initial rate of release leading to a 4.5 h delay in reaching the same antibiotic release percentage, whilst conservation of the activity of the antibiotic was simultaneously maintained. Thus, plasma polymerisation on the surface of bioceramics may be a good strategy to design controlled drug delivery matrices for local bone therapies. © 2016 IOP Publishing Ltd.

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