Biomatlante SA

Vigneux-de-Bretagne, France

Biomatlante SA

Vigneux-de-Bretagne, France

Time filter

Source Type

Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2009-1.4-2 | Award Amount: 15.47M | Year: 2010

Bone is among the most frequently transplanted tissue with about 1 million procedures annually in Europe. The worldwide market of bone replacement materials is currently estimated at 5 billion with a 10% annual growth. Despite their considerable disadvantages, including the risk of disease transfer and immunologic rejection, limited supply of bone, costs and complications, allografts and autografts account for more than 80% of total graft volume. Significant growth opportunities exist for synthetic bone grafts in association with mesenchymal stem cells from autologous or allogenic sources as alternatives to biological bone grafts in orthopaedic and maxillofacial surgery. The objectives of REBORNE is to perform clinical trials using advanced biomaterials and cells triggering bone healing in patients. In order to reach this goal, five phase II clinical studies with 20 patients are proposed in 12 clinical centres spread in 8 European countries. Three orthopaedic trials concerning the treatment of long bone fractures and osteonecrosis of the femoral head in adults or children will be conducted using bioceramics, hydrogel for percuteneous injection and stem cells from autologous or allogenic sources. Clinical research will also concern maxillofacial surgery with bone augmentation prior to dental implants and the reconstruction of cleft palates in children. The safety and efficacy of the new therapies will be assessed clinically using X-rays, CT scans and MRI as well as histology of biopsies. These ambitious clinical targets will require research and development efforts from a large consortium of top world class laboratories, SMEs manufacturing biomaterials, GMP-cell producing facilities and surgeons in hospitals as well as the consideration of ethical and regulatory issues. It is expected that REBORNE will expand the competitiveness of Europe through the patenting of new CE-marked bioproducts in the field of regenerative medicine.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP-2009-2.3-1 | Award Amount: 4.08M | Year: 2010

This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of regenerative bioactivity on command and demand. A gene-activated matrix is a biomaterial with embedded gene vectors that will genetically modify cells embedded in the matrix. The platform comprises modules that self-adapt to the biological environment and that can be independently addressed with endogenous biological and exogenous physical or pharmacological stimuli, resulting in a temporally and spatially coordinated growth factor gene expression pattern. This reproduces, within the matrix, key elements of natural tissue formation. The modules are a biomimetic hyaluronan gel, a ceramic matrix, growth factor-encoding gene vector nanoparticles, magnetic nanoparticles and mesenchymal stem cells. Anatomical adaptivity is achieved with engineered thermal properties of the polymer matrix, which embeds other modules, selected according to functional requirements. Mechanical support is provided by Micro Macroporous Biphasic Calcium Phosphate (MBCP), a resorbable material approved for clinical use. Spatiotemporal control of bioactivity and responsiveness to physiological conditions is represented, firstly, in the spatial distribution and release profiles of gene vectors within the composite matrix and, secondly, by letting local and external biological or physical stimuli activate the promoters driving the expression of vector-encoded transgenes. This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a focused plan of dissemination, public participation, gender equality and transition to market.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Rouillon T.,University of Nantes | Daculsi G.,University of Nantes
Key Engineering Materials | Year: 2015

Solid-state transformation of CDA at high temperature has been investigated using TEM microscopy and diffraction from sintered biphasic calcium phosphate (hydroxyapatite-HA, and beta-tricalcium phosphate-TCP). Microcrystals, between 200nm and 800nm approximately, separated by grain boundaries were found to be either HA-HA or TCP-TCP, but not HA-TCP, suggesting that heteroepitaxial growth is very unlikely between these two orthophosphates. TEM-correlated EDX elemental analysis also demonstrated a higher ionic substitution (Na, Mg) of TCP phase. © (2015) Trans Tech Publications, Switzerland.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Galtier T.,Biomatlante SA | Daculsi G.,University of Nantes | Borget P.,Biomatlante SA
Key Engineering Materials | Year: 2015

The present study focuses on the physico-chemical and structural properties of composite scaffolds composed of biopolymer matrices (collagen or polysaccharide) loaded with calcium phosphate granules. A systematic three-dimensional analysis method was used to quantitatively characterize a series of plugs, strips and putties in terms of percentage of inorganic filler particles, size of the loaded granules, and spatial homogeneity of the calcium phosphate granules distribution. It appears clearly that each biomaterial currently available on the market offers specific properties. As a consequence, surgeons have to choose the medical device that best suits their needs depending on the clinical constraints but also should be aware of the mineral properties which remains key to bone reconstruction [1-2]. © (2015) Trans Tech Publications, Switzerland.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Borget P.,Biomatlante SA | Moreau F.,Biomatlante SA | And 2 more authors.
Key Engineering Materials | Year: 2016

Bioceramics draw attention in bone tissue engineering field since their biomimetic properties regarding bone attribute. In this context, a concept of smart bioceramics granules made of Hydroxyapatite have been set up, enhancing surface area available to body fluids containing proteins and cell adhesion for bone forming respectively due to the microporosities and macropore concavities. New "hollow shell" granules were developed and assessed by physico-chemical characterizations, in-vitro experiments and in-vivo implantation in comparison with classical round granules. This new original galenic formulation showed promising potential in cell carrying and osteoconduction matter. © 2016 Trans Tech Publications, Switzerland.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Aguado E.,University of Nantes | Goyenvalle E.,University of Nantes | And 3 more authors.
IRBM | Year: 2013

Heat-induced osteonecrosis represents a simple, rapid, and inexpensive method for reproducing the effects of bone disease. In the present study, we employed this technique to induce osteonecrosis in femoral defects in rabbits and assessed the efficacy of treatment using Biphasic Calcium Phosphate (BCP) granules (MBCP+™, Biomatlante SA). After 3 weeks, the osteopromotion effects of BCP granules could be statistically proven (P < 0.05) through image analysis of newly formed bone in osteonecrosed sites containing BCP granules when compared to empty control sites. Increasing mature and woven bone presence was observed after 6 and 12 weeks, forming new trabeculae in necrosed site. Significant statistical differences were evidenced at each time between empty necrosed and filled necrosed defects in terms of new bone volume. © 2013 Elsevier Masson SAS.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Borget P.,Biomatlante SA | Baroth S.,Biomatlante SA | Daculsi G.,University of Nantes
Key Engineering Materials | Year: 2014

Physico-chemical characteristics impact directly or indirectly the bioactive properties of biomaterials, it is then essential to correlate it with their effect in vivo. A panel of biomaterials available on the market, based on Hydroxyapatite (HA) and Tricalcium phosphate (β-TCP) is studied in terms of surface area, hydrophilicity, porosity, zeta potential, crystalline phases and density. This study highlights the dispersity of commercial calcium phosphates (CaP) properties, and demonstrates how the quality criteria required for such bone substitute based on biomimicry concept, whose pores distribution is certainly the more relevant, are often incompletely or not respected according to literature. © (2014) Trans Tech Publications, Switzerland.


Miramond T.,University of Nantes | Miramond T.,Biomatlante SA | Corre P.,University of Nantes | Borget P.,Biomatlante SA | And 4 more authors.
Journal of Biomaterials Applications | Year: 2014

Bioceramics combined with isolated stem cells, or with total bone marrow, constitute the main strategies under consideration in the field of bone tissue engineering. In the present preclinical study, two biphasic calcium phosphate scaffolds currently on the market, MBCP® and MBCP+®, with different hydroxyapatite/β-tricalcium phosphate ratio, were implanted ectopically in a nude mouse model. These scaffolds were supplemented either with human mesenchymal stromal cells, or with human total bone marrow, or rat total bone marrow. Biomaterials alone were found to have potentially low, but non-zero, osteoinductive properties, while biomaterials associated with total bone marrow consistently improved osteoinduction in comparison with high concentrations of isolated human stromal cells. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.


Daculsi G.,University of Nantes | Baroth S.,University of Nantes | Baroth S.,Biomatlante SAS | LeGeros R.,New York University
Ceramic Engineering and Science Proceedings | Year: 2010

We developed 20 years ago, biphasic calcium phosphate ceramics (BCP). The BCP concept is determined by a balance of the more stable HA phase and more soluble TCP. BCP is gradually resorbed, seeding new bone formation. The main attractive feature of BCP is the ability to form a direct bone bonding resulting in a strong interface. This interface is the result of a sequence of events involving interaction with cells; and dissolution/precipitation processes. The efficiency of BCP concept was due to: (1) partial dissolution of the CaP ceramic macrocrystals inducing an increase in the calcium and phosphate ions concentration in the local microenvironment; (2) formation of carbonate hydroxyapatite CHA, (3) incorporation of these microcrystals with the collageneous matrix and non collagenic proteins like growth factors and others, in the newly formed bone. The BCP/bone interface represent a dynamic process, including physico-chemical processes, crystal/proteins interactions, cells and tissue colonization, bone remodelling. BCP have the advantage of bioactivity control by changing the HA and β-TCP ratio. BCP are osteoconductive and osteoinductive through appropriate critical geometry of microporosity. Besides the medical and dental applications, BCP has a potential for other applications such as delivery system for drugs, antibiotics, hormones; carriers for growth factors; scaffolds for tissue engineering. Specific matrices for combination with bone marrow or stem cells; and the need of material for Minimal Invasive Surgery (MIS) induced the development of injectable BCP granules. This paper summarizes 20 years of development of BCP and derivatives.


PubMed | University of Nantes and Biomatlante SA
Type: Journal Article | Journal: Journal of biomaterials applications | Year: 2014

Bioceramics combined with isolated stem cells, or with total bone marrow, constitute the main strategies under consideration in the field of bone tissue engineering. In the present preclinical study, two biphasic calcium phosphate scaffolds currently on the market, MBCP and MBCP+, with different hydroxyapatite/-tricalcium phosphate ratio, were implanted ectopically in a nude mouse model. These scaffolds were supplemented either with human mesenchymal stromal cells, or with human total bone marrow, or rat total bone marrow. Biomaterials alone were found to have potentially low, but non-zero, osteoinductive properties, while biomaterials associated with total bone marrow consistently improved osteoinduction in comparison with high concentrations of isolated human stromal cells.

Loading Biomatlante SA collaborators
Loading Biomatlante SA collaborators