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Holve D.L.,Eye Care for Animals | Mundwiler K.E.,Biological Test Center | Pritt S.L.,Absorption Systems
Comparative Medicine | Year: 2011

Laboratory rabbits are commonly used for ocular drug and device studies. The purpose of this study was to determine the incidence of spontaneous ocular lesions in laboratory rabbits with respect to sex, breed, and supplier. We retrospectively evaluated ophthalmic examination records of rabbits screened between April 2008 and April 2010. These 1840 records represented 572 black Dutch belted (DB), 1022 New Zealand white (NZW), and 246 NZW x New Zealand red F1 crosses (WRF1). Rabbits were between 6 and 16 wk of age and had been received from 5 suppliers. Ocular structures evaluated were the cornea, lens, iris and vitreous with respect to sex, breed and supplier. A total of 177 rabbits (9.6%) and 233 eyes (6.3%) were effected. Of total rabbits, 15.3% males and 7.3% females were affected. The most common structure affected was the cornea in 5.7% of rabbits, (DB 11.7%, NZW 3.0%, and NZR 3.3%). The lens at 3.6% was second most common (DB 2.1%, NZW 4.6%, and NZR 3.3%). Both iris (0.2%) and vitreous (0.3%) were not significantly affected. Significant sex-breeder-supplier combinations were: cornea DB supplier D, supplier D females, supplier D males, DB males and NZR females; and lens: NZW females; and at least one affected ocular structure: NZW supplier D, supplier D females, DB males, NZW females, and NZR females. Breed, sex, and supplier were significant variables of ocular lesions in laboratory rabbits. Investigators should consider each of these variables when choosing rabbits for ocular studies. Copyright 2011 by the American Association for Laboratory Animal Science. Source

Minnich K.E.,B. Braun Medical Inc. | Stolarick R.,B. Braun Medical Inc. | Wilkins R.G.,Moog | Chilson G.,Moog | And 2 more authors.
Ostomy Wound Management | Year: 2012

Polyhexanide and betaine topical solution is used in the management of infected wounds as a cleaning agent. An in vitro study was conducted to examine the antimicrobial effects of a solution containing 0.1% of the antimicrobial agent polyhexanide and 0.1% of the surfactant betaine. Three batches of each product were tested, and culture results of 13 microorganisms were evaluated after 7, 14, and 28 days using USP <51> methodology. Growth reduction was identical at each day following exposure to the solution in all micro-organisms except Aspergillus brasiliensis. A range of 5.3-log to 5.8-log reduction was seen for the following micro-organisms: Staphylococcus epidermidis, Pseudomonas aeruginosa, Serratia marcescens, Candida albicans, S. aureus, vancomycin-resistant Enterococcus faecalis, Proteus mirabilis, Escherichia coli, methicillin-resistant S. aureus, Acinetobacter baumannii, Enterobacter cloacae, and E. faecalis. For A. brasiliensis, reductions were 2.1-log, 2.3-log and 2.8-log at 7, 14, and 28 days, respectively. The results of this study indicate a 4+ log inhibition of activity in 12 of 13 micro-organisms exposed to the solution. Research to elucidate the potential clinical effects of these observations is needed. Source

Pritt S.L.,Biological Test Center | Mackta J.,Global Research Education and Training
Journal of the American Association for Laboratory Animal Science | Year: 2010

Business models for transnational organizations include linking different geographies through common codes of conduct, policies, and virtual teams. Global companies with laboratory animal science activities (whether outsourced or performed inhouse) often see the need for these business activities in relation to animal-based research and benefit from them. Global biomedical research organizations can learn how to better foster worldwide cooperation and teamwork by understanding and working with sociocultural differences in ethics and by knowing how to facilitate appropriate virtual team actions. Associated practices include implementing codes and policies transcend cultural, ethnic, or other boundaries and equipping virtual teams with the needed technology, support, and rewards to ensure timely and productive work that ultimately promotes good science and patient safety in drug development. Copyright 2010 by the American Association for Laboratory Animal Science. Source

Boorman G.,Covance Laboratories Inc. | Crabbs T.A.,Experimental Pathology Laboratories Inc. | Kolenda-Roberts H.,Experimental Pathology Laboratories Inc. | Latimer K.,Covance Laboratories Inc. | And 13 more authors.
Toxicologic Pathology | Year: 2012

The 2011 annual National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held in Denver, Colorado in advance of the Society of Toxicologic Pathology's 30th Annual Meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers' presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting or discussion. Some lesions and topics covered during the symposium include: proliferative lesions from various fish species including ameloblastoma, gas gland hyperplasia, nodular regenerative hepatocellular hyperplasia, and malignant granulosa cell tumor; spontaneous cystic hyperplasia in the stomach of CD1 mice and histiocytic aggregates in the duodenal villous tips of treated mice; an olfactory neuroblastoma in a cynomolgus monkey; various rodent skin lesions, including follicular parakeratotic hyperkeratosis, adnexal degeneration, and epithelial intracytoplasmic accumulations; oligodendroglioma and microgliomas in rats; a diagnostically challenging microcytic, hypochromic, responsive anemia in rats; a review of microcytes and microcytosis; nasal lesions associated with green tea extract and Ginkgo biloba in rats; corneal dystrophy in Dutch belted rabbits; valvulopathy in rats; and lymphoproliferative disease in a cynomolgus monkey. © 2012 Society of Toxicologic Pathology. Source

Ko P.P.,Biological Test Center | Pritt S.L.,Biological Test Center | Mundwiler K.E.,Biological Test Center | Ackley V.K.,Biological Test Center | And 2 more authors.
Journal of the American Association for Laboratory Animal Science | Year: 2011

A 26.6-kg, intact, 9-mo-old female Göttingen minipig was presented for a coronary stent study. Angiography revealed a sinus of Valsalva aneurysm (SVA) in the aortic root that involved both the left and noncoronary sinuses of the heart. Gross histologic examination of the heart revealed 2 regions of aneurysmal formation: one at the ostium to the left main coronary artery, with aortic sinus involvement, and the other at the dorsal aspect of the aortic root involving the noncoronary aortic sinus. With no history of any infectious diseases, and the microscopic findings showing no evidence of necrosis, degeneration, or infection, confirmed that the aneurysmal-like dilation of the sinuses was most likely a congenital anomaly. This case illustrates the diagnosis and comparative findings of a rare cardiac anomaly found in only a few species to date. To our knowledge, antemortem diagnosis of unruptured SVA involving both the left and noncoronary aortic sinuses of the minipig heart has not been reported previously. Copyright 2011 by the American Association for Laboratory Animal Science. Source

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