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Grant
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2010-1.1.30 | Award Amount: 9.70M | Year: 2011

The central objective of this ESMI proposal is to create a top-level interdisciplinary research infrastructure available to a broad European materials research community. This is of crucial importance to the EU in view of the European strategy for nanosciences and nanotechnology and its implementation report that identifies a lack of leading interdisciplinary infrastructures. ESMI offers the most important experimental and synthesis techniques and combines world-class infrastructures with cutting edge scientific expertise through a sophisticated networking programme. The anticipated JRA will further improve the existing infrastructure. Computer simulations being of increasing importance for the understanding and prediction of complex materials, ESMI offers access to simulation groups and their advanced tools. The availability of such an infrastructure will provide soft matter scientists with a broad choice of techniques to address their scientific objectives. It will result in a quantum leap in research opportunities and assure that European scientists have a world-class collaborative capability for their frontier research. ESMI will strongly contribute to a fundamental understanding, allowing the development of new, tailored smart materials. ESMI follows the FP6 experience of the NoE SoftComp. A key feature developed within SoftComp is the highly successful Research Platforms offered to its members, anticipating the spirit of the EU Integrated Infrastructure Initiative. ESMI will promote the SoftComp experience to the European materials community, reflecting the EU recommendations that FP6 collaborative projects may well lead to new European infrastructures. Together with a platform for disseminating the results and educating a new generation of young soft matter scientists, ESMI represents an important added value to the European Research Area in nanoscience, nanotechnology and materials science


News Article | December 7, 2016
Site: globenewswire.com

7 December 2016 Ratos subsidiary Biolin Scientific Holding AB has divested Analytical Instruments (Biolin Scientific AB), a subsidiary in the Biolin Group, to the listed company AddLife. The sale is not expected to generate a significant exit gain for Ratos. Ratos acquired Biolin Scientific in 2010, and the company currently offers advanced analysis instruments that help scientists and enterprises to scientifically analyse materials, nanotechnologies and pharmaceuticals faster and better. Biolin Scientific's operations are conducted in two independent subsidiaries today called Analytical Instruments and Drug Discovery. In conjunction with the divestment of Analytical Instruments, Drug Discovery will be run as an independent company in Ratos under the name Sophion, and shared Group-wide resources will be discontinued. Analytical Instruments has about 60 employees, with annual sales of approximately SEK 100m and operating EBITA of approximately SEK 6m based on the most recent 12 months as per September 2016. "We have chosen to divest Analytical Instruments to AddLife, which will become a new, long-term owner with similar operations in Life Science. At the same time, this will enable increased focus on Sophion's core operations as an independent company," says Christina Rubenhag, CEO of Biolin Scientific Holding. The divestment is not expected to generate a significant exit gain for Ratos. Sophion will be recognised as other net assets in Ratos's accounts for the full year 2016. For further information, please contact: Magnus Agervald, CEO Ratos, +46 8 700 17 00 Elin Ljung, Head of Corporate Communications Ratos, +46 8 700 17 20 Financial calendar from Ratos: Year-end report 2016                               17 February 2017 Ratos is an investment company that owns and develops unlisted medium-sized companies in the Nordic countries. Our goal as an active owner is to contribute to long-term and sustainable business development in the companies we invest in and to make value-generating transactions. Ratos's portfolio consists of 20 medium-sized Nordic companies and the largest segments in terms of sales are Consumer goods/Commerce, Construction and Industrials. Ratos is listed on Nasdaq Stockholm and has approximately 15,500 employees.


AddLife has signed an agreement to acquire all the shares in the company Biolin Scientific AB, part of the group Biolin Scientific, owned by Ratos. The Company is a leading Nordic developer and producer of analytical instruments for material analysis at the nanoscale. The products are demanded both from universities and industry all over the world. The business has shown long term profitability and growth, has an attractive product portfolio and is world leading within its niche, material science. The ownership will come effective today and the Company will be part of the business area Labtech within AddLife. The acquisition is the fourth since the listing of AddLife in March earlier this year. The world leading technique, that is the foundation within Biolin Scientific, is based on innovative academic research at Chalmers, in measurement technology at the nanoscale. The Company has during several years had a strong international growth with good profitability and a turnover of about SEK 100 million. Today the customers are mainly within research all over the world, both within the academia and industry. The Company has global sales through their own subsidiaries in US, UK and China but also through distributors. The head quarter is in Sweden and research and production are both in Sweden and Finland. Biolin Scientific AB with its subsidiaries has in total 61 employees. - Material analysis at the nanoscale is an expansive and exciting area where global developments emerge rapidly. As a world leading supplier of instruments for studies of material characteristics at the nanoscale Biolin Scientific contribute to creating new innovative products and solutions in a variety of areas for their customers. We look forward to the opportunity to further develop the company in a global market, says Peter Simonsbacka, Business area manager Labtech, AddLife AB. The acquisition of BiolinScientific means an expansion of AddLife in own high-tech products. The acquisition also entails a further international expansion of AddLife outside the Nordic region. The acquisition is expected to have a marginally positive effect on AddLife’s earnings per share. AddLife is an independent player in Life Science that offers high-quality products, services and advice to both the private and public sector, mainly in the Nordic region. AddLife has about 460 employees in some 25 subsidiaries that operate under their own brands. The Group has annual sales of about SEK 1.8 billion. AddLife shares are listed on NASDAQ Stockholm. This information is information that AddLife AB is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 08:30 CET on 7 December 2016. This information was brought to you by Cision http://news.cision.com


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 10.76M | Year: 2016

An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual toolbox that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.


Barzyk W.,Polish Academy of Sciences | Vuorinen J.,Biolin Scientific
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2011

This paper describes the measuring procedure which enables overcoming the base difficulty in application of the vibrating plate (VP) technique to measuring electric surface potential (ΔV) of free solution surfaces, namely loosing the zero level set for the reference sample (water) while replacing it with the solution measured. (The ΔV measurement is performed by comparing two measurements in series, i.e., for the pure interface and that containing a surface film.) Main improvement in the measuring procedure is achieved by (i) applying a flow for exchanging the reference sample with the measured solution and (ii) elimination of an error driven by dependency of the measuring signal on the air gap width. The air gap width is fixed by contact of the bottom edge of a platinum Wilhelmy plate with the solution surface which the plate is simultaneously used for measurement of the surface pressure (Π). The results received with the new methodology for n-decanoic acid, n-decyl-trimethylammonium bromide (C10TABr) and sodium n-dodecyl sulphate (SLS) are discussed. © 2011 Elsevier B.V.


Eisele N.B.,CIC Biomagune | Eisele N.B.,Max Planck Institute for Biophysical Chemistry | Andersson F.I.,Biolin Scientific | Frey S.,Max Planck Institute for Biophysical Chemistry | And 2 more authors.
Biomacromolecules | Year: 2012

Immobilization of proteins onto surfaces is useful for the controlled generation of biomolecular assemblies that can be readily characterized with in situ label-free surface-sensitive techniques. Here we analyze the performance of a quartz crystal microbalance with dissipation monitoring (QCM-D) sensor surface that enables the selective and oriented immobilization of histidine-tagged molecules for morphological and interaction studies. More specifically, we characterize monolayers of natively unfolded nucleoporin domains that are rich in phenylalanine-glycine repeats (FGRDs). An FGRD meshwork is thought to be responsible for the selectivity of macromolecular transport across the nuclear pore complex between the cytosol and the nucleus of living cells. We demonstrate that nucleoporin FGRD films can be formed on His-tag Capturing Sensors with properties comparable to a previously reported immobilization platform based on supported lipid bilayers (SLB). Approaches to extract the film thickness and viscoelastic properties in a time-resolved manner from the QCM-D response are described, with particular emphasis on the practical implementation of viscoelastic modeling and a detailed analysis of the quality and reliability of the fit. By comparing the results with theoretical predictions for the viscoelastic properties of polymer solutions and gels, and experimental data from an atomic force microscopy indentation assay, we demonstrate that detailed analysis can provide novel insight into the morphology and dynamics of FG repeat domain films. The immobilization approach is simple and versatile, and can be easily extended to other His-tagged biomolecules. The data analysis procedure should be useful for the characterization of other ultrathin biomolecular and polymer films. © 2012 American Chemical Society.


Li J.,Bristol Myers Squibb | Pinnamaneni S.,Bristol Myers Squibb | Quan Y.,Bristol Myers Squibb | Jaiswal A.,Biolin Scientific | And 2 more authors.
Pharmaceutical Research | Year: 2012

Purpose: To investigate interactions between protein and silicone oil so that we can provide some mechanistic understanding of protein aggregation in silicone oil lubricated syringes and its prevention by formulation additives such as Polysorbate 80 and Poloxamer 188. Methods: Interfacial tension values of silicone oil/water interface of abatacept solutions with and without formulation additives were obtained under equilibrium conditions using Attension Theta optical tensiometer. Their adsorption and desorption profiles were measured using Quartz Crystal Microbalancing with Dissipation monitoring (QCM-D). The degree of aggregation of abatacept was assessed based on size exclusion measurement. Results: Adsorption of abatacept at the oil/water interface was shown. Polysorbat 80 was more effective than Poloxamer 188 in preventing abatacept adsorption. Moreover, it was noted that some of the adsorbed abatacept molecules were not desorbed readily upon buffer rinse. Finally, no homogeneous aggregation was observed at room temperature and a slight increase of aggregation was only observed for samples measured at 40°C which can be prevented using Polysorbate 80. Conclusions: Interfacial adsorption of proteins is the key step and maybe responsible for the phenomenon of soluble-protein loss when contacting silicone oil and the irreversible adsorption of protein may be associated with protein denaturation/aggregation. © 2012 Springer Science+Business Media, LLC.


Stavila V.,Sandia National Laboratories | Volponi J.,Sandia National Laboratories | Katzenmeyer A.M.,Sandia National Laboratories | Dixon M.C.,Biolin Scientific | Allendorf M.D.,Sandia National Laboratories
Chemical Science | Year: 2012

We describe a systematic investigation of the factors controlling step-by-step growth of the metal-organic framework (MOF) [Cu 3(btc) 2(H 2O) 3]·xH 2O (also known as HKUST-1), using quartz crystal microbalance (QCM) electrodes as an in situ probe of the reaction kinetics and mechanism. Electrodes coated with silica, alumina and gold functionalized with OH- and COOH-terminated self-assembled monolayers (SAMs) were employed to determine the effects of surface properties on nucleation. Deposition rates were measured using the high sensitivity available from QCM-D (D = dissipation) techniques to determine rate constants in the early stage of the process. Films were characterized using grazing incidence XRD, SEM, AFM, profilometry and reflection-absorption IR spectroscopy. The effects of reaction time, concentration, temperature and substrate on the deposition rates, film crystallinity and surface morphology were evaluated. The initial growth step, in which the surface is exposed to copper ions (in the form of an ethanolic solution of copper(ii) acetate) is fast and independent of temperature, after which all subsequent steps are thermally activated over the temperature range 22-62 °C. Using these data, we propose a kinetic model for the Cu 3(btc) 2 growth on surfaces that includes rate constants for the individual steps. The magnitude of the activation energies, in particular the large entropy decrease, suggests an associative reaction with a tight transition state. The measured activation energies for the step-by-step MOF growth are an order of magnitude lower than the value previously reported for bulk Cu 3(btc) 2 crystals. Finally, the results of this investigation demonstrate that the QCM method is a powerful tool for quantitative, in situ monitoring of MOF growth in real time. © 2012 The Royal Society of Chemistry.


Heljo P.S.,Tampere University of Technology | Li M.,Tampere University of Technology | Lilja K.E.,Tampere University of Technology | Lilja K.E.,Biolin Scientific | And 3 more authors.
IEEE Transactions on Electron Devices | Year: 2013

Presently, most circuits fabricated using organic materials and printing methods have been adopted directly from solid-state inorganic electronics. However, the characteristics of organic electronic devices can differ remarkably from their inorganic equivalents, and therefore, the performance assumptions made about inorganic devices may not be applicable in organic electronics. In this paper, we report a printed diode-based half-wave rectifier having high yield, good air stability, and 3.5-V dc output at 13.56 MHz. Due to the high yield and good performance of the individual diodes, fabrication of more complex devices is possible. In order to achieve higher output power and lower ripple voltage, a printed full-wave bridge rectifier is reported. In addition, the half-wave and the full-wave rectifier circuits are consistently compared with each other. The output waveforms, voltages, and power values are presented for both rectifying circuits. The output measurement results show that the full-wave rectifier has lower output power and lower output voltage due to the high voltage drop of the printed diodes. Therefore, the full-wave rectifier would be most useful in low-frequency applications where low ripple voltage or small capacitor area is required. © 1963-2012 IEEE.


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