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Saint-Herblain, France

Zair Y.,Institut Universitaire de France | Duclos E.,Compagnie des Peches Saint Malo Sante | Housez B.,Biofortis | Vergara C.,Clinical Trials Unit | And 2 more authors.
Nutrition and Food Science | Year: 2014

Purpose – This paper aims to investigate the satiety properties of a fish protein hydrolysate (blue whiting muscle hydrolysate, BWMH). Protein consumption is associated with higher satiety, protein being considered as the more satiating macronutrient. This property is extensively investigated in regard to weight management.Design/methodology/approach – Fifteen overweight women were included in a crossover design study. Subjects consumed 1 g of BWMH or placebo twice daily and sensations associated with satiety were recorded every day.Findings – Significant differences, in favour of BWMH, were highlighted on the desire to eat something sweet at T90 min (p < 0.05) and on plasma glucose at T270 min (p < 0.05).Research limitations/implications – This study demonstrates effect of BWMH on appetite. Indeed promising data were reported in favour of the test product, in particular on the desire to eat something sweet and on glucose levels. Some additional investigations will be necessary to support these data and those observed in in vitro and in vivo models. © Emerald Group Publishing Limited.

Pincemail J.,University of Liege | Paquot N.,University of Liege | Cillard J.,University of Rennes 1 | Hininger I.,LBFA INSERM884 UFR of Pharmacy | And 8 more authors.
Journal of Pharmacy and Nutrition Sciences | Year: 2013

The present study was designed to test the hypothesis that an increased consumption of fruits and vegetables up to 600 g per day in type 2 diabetes patients can reduce oxidative damages to lipids. After a clinical examination, 29 type 2 diabetes patients were divided into two groups: the first one did not receive any special instructions about the diet while the second one received fruits and vegetables consumption advices thanks to a picture catalogue describing types of fruits and vegetables as well as quantities to be eaten every day. After two months of intervention, plasma concentrations in vitamin C, β-carotene and polyphenols remained unchanged in both groups when compared to baseline values. No significant decrease in lipid peroxidation as evidenced by nine biomarkers (malonaldehyde as TBAR's, lipid peroxides, oxidized LDL, antibodies against oxidized LDL, isoprostanes, 7-keto-cholesterol, 7β- hydroxycholesterol, 4-hydroxynonenal metabolite, LDL size) was also noted. In conclusion, our findings confirmed the fact that the effect of high intake of fruits and vegetables on reducing oxidative damage to lipids remains largely controversial even in patients having an oxidative stress profile. Moreover, the present leaves open the question of the most appropriate markers of lipid peroxidation since only small correlations were evidenced between the large battery of tests investigated. © 2013 Lifescience Global.

Vandenplas Y.,UZ Brussel | Cazaubiel M.,Biofortis | Housez B.,Biofortis | Bocquet A.,Pour lAssociation Francaise des Pediatres Ambulatoires
Journal of Pediatric Gastroenterology and Nutrition | Year: 2013

Background and Aim: Many mothers consult physicians because of frequent infant regurgitation. Guidelines recommend reassurance and dietary treatment as first approaches. The aim of the present study was to test and compare the efficacy of 2 antiregurgitation formulae (ARF). Methods: A prospective, double-blind, randomized cross-over trial was performed for a 1-month period in 115 formula-fed infants (ages 2 weeks-5 months) comparing 2 ARF (ARF-1: nonhydrolyzed protein, locust bean gum; ARF-2: specific whey hydrolysate, locust bean gum, specially treated starch). The primary endpoint was the incidence of regurgitation. Results: At inclusion, mean age was 9.1 weeks; anthropometric parameters did not differ between the groups. According to the intention-to-treat analysis, the mean number of episodes of regurgitation decreased from 8.25 to 2.32 with ARF-1 and to 1.89 with ARF-2 (statistically significant difference between both ARF, P=0.0091). The mean score of regurgitated volume decreased significantly more with ARF-2 than with ARF-1 (P=0.0265). There was no significant difference in stool frequency and consistency between both groups. Conclusions: The efficacy of both ARF was demonstrated by the decreased number and volume of regurgitations. ARF-2 was statistically more effective than ARF-1. Comparative trials enable the selection of the best therapeutic option. © 2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

Guerin-Deremaux L.,Roquette Freres | Wils D.,Roquette Freres | Cazaubiel M.,Biofortis | Housez B.,Biofortis
International Journal of Food Sciences and Nutrition | Year: 2011

NUTRIOSE®FB10 is a dextrin considered a dietary fiber. The present study aims to assess the digestive tolerance of a high dose of NUTRIOSE®FB10 consumed over the day, and its effect on digestive symptoms. In a randomized, double-blind, cross-over trial, 12 healthy men ingested 1 l/day orange juice containing 50 g either NUTRIOSE ®FB10 or placebo (maltodextrin) in three equal doses at breakfast, lunch and 4:00 pm meal. Bloating, borborygmus, flatulence, nausea feelings, stomach ache, transit and stool consistency were evaluated at different times after the first consumption. Questionnaires on well-being and bowel movement were completed at 24 and 48 h. For all data except stool consistency, the area under the curve, the maximum score and the time of this maximum were calculated. For stool consistency, the mean score over 48 h was determined. There was no statistical difference between NUTRIOSE ®FB10 and placebo on each criterion. NUTRIOSE®FB10 is well tolerated during a single day at 50 g divided into three doses. © 2011 Informa UK, Ltd.

Marteau P.,University Paris Diderot | Jacobs H.,Cosucra Groupe Warcoing | Cazaubiel M.,Biofortis | Signoret C.,Cosucra Groupe Warcoing | And 2 more authors.
International Journal of Food Sciences and Nutrition | Year: 2011

The impact of the daily consumption of 15 g chicory native inulin on fecal levels of bifidobacteria, stool parameters and quality of life of elderly constipated volunteers was investigated in a randomized, double-blind, controlled versus placebo clinical trial. The impact of supplementation on constipation was assessed with questionnaires on bowel motor function parameters, visual analogue scales on bowel symptoms and quality of life. Fecal bacteria counts were determined at the beginning and at the end of the supplementation. Inulin supplementation led to a significant increase in total fecal bacteria (P < 0.01) and bifidobacteria (P < 0.001) concentrations after 28 days of consumption. Volunteers (n = 25) in the inulin group reported increased satisfaction about digestion (P < 0.01) and reduced defecation difficulties (P < 0.001) during the supplementation. Slight gastrointestinal symptoms (flatulence) were reported but did not lead to discontinuation. Daily supplementation with 15 g inulin improves constipation and quality of life in an elderly population with constipation. © 2011 Informa UK, Ltd.

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