BioControl Systems Inc.

Bellevue, WA, United States

BioControl Systems Inc.

Bellevue, WA, United States

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Patent
BioControl Systems Inc. | Date: 2016-08-04

Methods and apparatus for evaluating the quality of an environment or process by measuring light emitted from a bioluminescent sample containing ATP, ADP, or alkaline phosphatase. The apparatus comprises a sample collection and analysis system used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The system includes an instrument having a photon detection assembly for use with the sample testing device and one or more probe assemblies that optically cooperate with the instrument. The instrument includes a dark chamber with a reflective interior surface which may be concave or preferably spherical, and a photon detection sensor such as a multi-pixel photon counter sensor. A substantially transparent portion of the probe assembly, and liquid contained therein, focus bioluminescence toward the photon detection sensor.


PubMed | BioControl Systems Inc., U.S. Food and Drug Administration, Brodsky Consultants and Q Laboratories Inc.
Type: Journal Article | Journal: Journal of AOAC International | Year: 2016

Assurance GDS() MPX ID for Top Shiga toxin-producing Escherichia coli (STEC; MPX ID) was validated according to the AOAC INTERNATIONAL Methods Committee Guidelines for Validation of Microbiological Methods for Foods and Environmental Surfaces as (1) a secondary screening method for specific detection of the Top 6 STEC serogroups (O26, O45, O103, O111, O121, and O145) in raw beef trim, raw ground beef, raw spinach, and on stainless steel; and (2) as a confirmatory method for the identification of pure culture isolates as Top 6 STEC. MPX ID is used in conjunction with the upfront BCS Assurance GDS MPX Top 7 STEC assay. This Performance Tested Method(SM) validation has two main parts: Method Developer studies and the Independent Laboratory study. A total of 180 samples and controls were analyzed. Results showed that MPX ID had no statistically significant differences with the reference culture methods for the detection of Top 6 STEC in the food matrixes (raw beef trim, raw ground beef, and raw spinach) and environmental sponges (stainless steel) studied. Inclusivity/exclusivity studies were also conducted. One hundred percent inclusivity among the 50 Top 6 STEC serovars tested and 100% exclusivity for the 30 non-Top 6 STEC organisms tested were demonstrated. For validation of MPX ID as a confirmatory method for isolated colonies, all inclusivity and exclusivity organisms were streaked for isolation onto five STEC plating media: modified rainbow agar, Levines eosin-methylene blue (L-EMB) agar, rainbow agar with novobiocin and cefixime, and enterohemolysin agar with selective agents as well as trypticase soy agar with yeast extract. These isolated colonies were suspended and analyzed by Assurance GDS MPX Top 7 STEC and MPX ID. MPX ID was able to correctly confirm all inclusivity organisms from all plate types, except two STEC isolates from L-EMB agar plates only in the Independent Laboratory study. All exclusivity organisms were correctly determined by MPX ID as non-Top 6 STEC from the STEC plating media. An additional but separate part of these studies was a comparison of immunomagnetic separation (IMS) efficiency using the Assurance GDS procedure with a PickPen() device and the U.S. Department of Agriculture procedure using the OctoMACS Separator device for plating onto chromogenic agar. Results demonstrated the equivalence of the two IMS procedures for plate confirmation of Top 7 STEC.


Feldsine P.T.,BioControl Systems Inc. | Jucker M.T.,BioControl Systems Inc. | Kaur M.,BioControl Systems Inc. | Lienau A.H.,BioControl Systems Inc. | Kerr D.E.,BioControl Systems Inc.
Journal of AOAC International | Year: 2010

A multilaboratory collaborative study was conducted to compare the detection of Salmonella by the Assurance GDS®for Salmonella method and the Reference culture methods. Six foods, representing a variety of low microbial and high microbial load foods were analyzed. Seventeen laboratories in the United States and Canada participated in this study. No statistical differences (P < 0.05) were observed between the Assurance GDS for Salmonella and the Reference culture methods for any inoculation level of any food type or naturally contaminated food, except for pasta, for which the Assurance GDS method had a higher number of confirmed test portions for Salmonella compared to the Reference method.


Magnetic enrichment method, wherein the desired biological component is collected from a solution, which component is thereafter enriched in a liquid in such a manner that by means of the micro particles attached to the magnet or attached by means of at least one magnet at least one biological component is collected in a closed reactor vessel. Thereafter at least one biological component is enriched in such a manner that the desired component is released to the solution. The reactor unit is a closed vessel, wherein the prevailing conditions are controllable. The shape and the location of the magnet unit in the reactor unit are adjusted in a preferable manner to collect the desired biological component.


Patent
BioControl Systems Inc. | Date: 2012-10-04

Methods and apparatus for evaluating the quality of an environment or process by measuring light emitted from a bioluminescent sample containing ATP, ADP, or alkaline phosphatase. The apparatus comprises a sample collection and analysis system used to collect a sample, mix reagents, react the sample, and collect it in a measurement chamber. The system includes an instrument having a photon detection assembly for use with the sample testing device and one or more probe assemblies that optically cooperate with the instrument. The instrument includes a dark chamber with a reflective interior surface which may be concave or preferably spherical, and a photon detection sensor such as a multi-pixel photon counter sensor. A substantially transparent portion of the probe assembly, and liquid contained therein, focus bioluminescence toward the photon detection sensor.


Patent
BioControl Systems Inc. | Date: 2011-11-18

Method for handling microparticles in such a manner, that at least two treatment steps are performed for microparticles in the same vessel without moving the particles to another vessel. There are organs in the device for changing the solution without having to move the microparticles to another vessel.


Patent
BioControl Systems Inc. | Date: 2013-04-29

Method for handling microparticles in such a manner, that at least two treatment steps are performed for microparticles in the same vessel without moving the particles to another vessel. There are organs in the device for changing the solution without having to move the microparticles to another vessel.


Trademark
BioControl Systems Inc. | Date: 2013-01-09

Electronic instruments and sampling devices for measuring multiple quality parameters not for medical use, namely, luminometers, bioluminescence meters, concentration meters, temperature meters, conductivity meters, pH meters, and data logging devices for ATP, temperature, pH, dissolved oxygen and conductivity; reagent-containing sampling devices for luminometers; battery chargers; computer software for analyzing data, calculating trends, plotting and storing data; probes not for medical use, namely pH probes, temperature probes, dissolved oxygen probes, and conductivity probes, all for use in detection and measurement of adenosine triphosphate (ATP) bioluminescence, conductivity, dissolved oxygen, pH, and temperature to provide an indication of sanitation levels, product quality and food safety of a test surface or sample.


Trademark
BioControl Systems Inc. | Date: 2016-12-23

Culture medium for use in procedures for the selective isolation and cultivation of Listeria.


PubMed | BioControl Systems Inc.
Type: Journal Article | Journal: Journal of AOAC International | Year: 2015

Assurance GDSTM for Salmonella Tq has been validated according to the AOAC INTERNATIONAL Methods Committee Guidelines for Validation of Microbiological Methods for Food and Environmental Surfaces for the detection of selected foods and environmental surfaces (Official Method of AnalysisSM 2009.03, Performance Tested MethodSM No. 050602). The method also completed AFNOR validation (following the ISO 16140 standard) compared to the reference method EN ISO 6579. For AFNOR, GDS was given a scope covering all human food, animal feed stuff, and environmental surfaces (Certificate No. TRA02/12-01/09). Results showed that Assurance GDS for Salmonella (GDS) has high sensitivity and is equivalent to the reference culture methods for the detection of motile and non-motile Salmonella. As part of the aforementioned validations, inclusivity and exclusivity studies, stability, and ruggedness studies were also conducted. Assurance GDS has 100% inclusivity and exclusivity among the 100 Salmonella serovars and 35 non-Salmonella organisms analyzed. To add to the scope of the Assurance GDS for Salmonella method, a matrix extension study was conducted, following the AOAC guidelines, to validate the application of the method for selected spices, specifically curry powder, cumin powder, and chili powder, for the detection of Salmonella.

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