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Nottingham, United Kingdom

Yu L.,Sun Yat Sen University | Wang L.,Sun Yat Sen University | Chen S.,Biocontrol
Biochimica et Biophysica Acta - Reviews on Cancer

As a major class of pattern-recognition receptors, Toll-like receptors (TLRs) play a critical role in defense against invading pathogens. Increasing evidence demonstrates that, in addition to infection, TLRs are involved in other important pathological processes, such as tumorigenesis. Activation of TLRs results in opposing outcomes, pro-tumorigenic effects and anti-tumor functions. TLR signaling can inhibit apoptosis and promote chronic inflammation-induced tumorigenesis. TLR activation in tumor cells and immune cells can induce production of cytokines, increase tumor cell proliferation and apoptosis resistance, promote invasion and metastasis, and inhibit immune cell activity resulting in tumor immune escape. In contrast, the engagement of other TLRs directly induces growth inhibition and apoptosis of tumor cells and triggers activation of immune cells enhancing anti-tumor immune responses. Thus, the interpretation of the precise function of each TLR in tumors is very important for targeting TLRs and using TLR agonists in tumor therapy. We review the role of TLR signaling in tumors and discuss the factors that affect outcomes of TLR activation. © 2012 Elsevier B.V. Source

Tricyglycerols that may be converted to biofuel are recovered from oleaginous organisms in the natural and induced foam of wastewater treatment process plants. Growing oleaginous organisms in the form of comparatively dry foam simplifies harvest and is more efficient and efficacious than skimming the biomass off the top of the liquids that rely on less efficient centrifugation or filtration methods typically required to concentrate cells grown in liquids.

Biocontrol | Date: 2013-05-29

The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce such sensitivity.

Biocontrol | Date: 2013-05-03

The present invention provides methods of designing panels of bacteriophages as therapeutic compositions against bacterial infections. The present invention also provides panels of bacteriophages for use in the prevention or treatment of bacterial infections.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: COMPET-04-2015 | Award Amount: 3.00M | Year: 2016

Microbiological contamination can be attenuated, never eliminated. Space exploration requires development of reliable rapid significant and safe methods for preventing, monitoring and control the biocontamination within manned closed environments. These methods have to be automated, simple and conceived to decrease the (re-)supply mass from ground. Both space and terrestrial monitoring and prevention/mitigation methods are currently working separately instead of working in synergy. The proposed BIOWYSE project foresees development and demonstration of an integrated system suitable for future accommodation aboard the International Space Station (ISS) and from a long-term viewpoint, within Moon and Mars habitats. The BIOWYSE consortium will design, build and test single prevention, monitoring and mitigation modules. Thus, they will be integrated in a single system inside a compact breadboard and tested. Critical aspects or gravity-dependent technologies of the breadboard will be designed with the perspective of a future accommodation within a rack of the ISS (e.g.: in EDR-2 of Columbus), as a precursor of elements for long-duration space missions and future planetary outposts (e.g. Mars). In order to validate key technologies for the biocontamination control integrated system in real conditions and with representative features, the BIOWYSE project is based on the following major objectives: 1. Exploitation of ISS data from recent project related to the system functionalities 2. Designing single modules taking into account the intent of a demonstration aboard an International Standard Payload Rack 3. Building a system in order to test integrated key technologies 4. Developing and demonstrating operational techniques and processes for preventing, monitoring and mitigating the microbiological risk in water loops 5. Actively leveraging synergies between space and non-space partners, evaluating the system efficiency in real platforms for water loops and wet surfaces

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