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Maltseva D.V.,BioClinicum Center
Bulletin of experimental biology and medicine | Year: 2012

The effects of 30-min medium-intensity exercise on the expression of genes encoding heat shock protein 70 (HSPA1A) and its cochaperones HSP-70-binding protein 1 (HSPBP1) and Tag7 (PGLYRP1) in human leukocytes were studied. Transcription activities of HSPA1A and PGLYRP1 genes increased immediately after medium-intensity exercise, while activity of HSPBP1 gene remained unchanged. During recovery after exercise, the expression of HSPA1A gene virtually did not change, while the expression of PGLYRP1 gene continued to increase and after 90 min more than 2-fold surpassed the basal level. Source


Maltseva D.V.,BioClinicum Center | Ryabenko E.A.,BioClinicum Center | Yashin D.V.,Russian Academy of Sciences | Khaustova S.A.,BioClinicum Center | Shkurnikov M.Yu.,Russian Academy of Medical Sciences
Bulletin of Experimental Biology and Medicine | Year: 2012

The effects of 30-min medium-intensity exercise on the expression of genes encoding heat shock protein 70 (HSPA1A) and its cochaperones HSP-70-binding protein 1 (HSPBP1) and Tag7 (PGLYRP1) in human leukocytes were studied. Transcription activities of HSPA1A and PGLYRP1 genes increased immediately after medium-intensity exercise, while activity of HSPBP1 gene remained unchanged. During recovery after exercise, the expression of HSPA1A gene virtually did not change, while the expression of PGLYRP1 gene continued to increase and after 90 min more than 2-fold surpassed the basal level. © 2012 Springer Science+Business Media New York. Source


Senyavina N.V.,BioClinicum Center | Khaustova S.A.,BioClinicum Center
Bulletin of Experimental Biology and Medicine | Year: 2013

Metabolome analysis of the serum from pregnant patients aimed at detection of low-molecular-weight biomarkers of gestation process disorders indicated a relationship between themetabolic profile of maternal serum and risk of gestosis. In women with pre-eclampsia or preterm delivery, analysis of serum purine metabolites revealed changes in the metabolite concentrations, associated with pregnancy complications. © 2013 Springer Science+Business Media New York. Source


Khaustova N.A.,BioClinicum Center | Makeeva D.S.,Moscow State University | Kondrashina O.V.,Moscow State University | Fedotov N.N.,Moscow State University | And 6 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2014

We compared the results of real-time PCR analysis of gene expression in paired specimens breast cancer tissue fixed in RNAlater (Qiagen) stabilization reagent (FF samples) and in formalin (FFPE samples). A clear-cut linear relationship (correlation coefficient 0.76∈±∈0.07) was detected between the gene expression logarithm values in FF and FFPE samples. This fact suggests that collections of paraffin blocks with formalin-fixed tissue specimens from patients with a many-year disease history can be effectively used in modern studies. © 2014 Springer Science+Business Media New York. Source

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