Patel K.R.,Biochemistry Research Division |
Patel K.R.,The Gujarat Cancer and Research Institute |
Vajaria B.N.,Biochemistry Research Division |
Vajaria B.N.,The Gujarat Cancer and Research Institute |
And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013
Background: p53 gene variants i.e. 16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies. Therefore, the present study evaluated the role of these p53 polymorphisms in oral cancer susceptibility in a population from Gujarat, West India. Method: Genotype frequencies at the three p53 loci in 110 controls and 79 oral cancer cases were determined by the PCR-RFLP method. Results: Heterozygous individuals at exon 4 showed protection from developing oral cancer. Homozygous wild and heterozygous individuals at intron 3 and those heterozygous at exon 4 in combination appeared to be at lowered risk. Furthermore, carriers of the 16 bp duplication allele at intron 3, proline allele at exon 4 and G allele at intron 6 were protected from oral cancer development. Conclusion: p53 polymorphisms, especially Arg72Pro in exon 4 could significantly modify the risk of oral cancer development in Gujarat, West Indian population.
Raval G.N.,Biochemistry Research Division |
Sainger R.N.,Biochemistry Research Division |
Rawal R.M.,Biochemistry Research Division |
Patel J.B.,Biochemistry Research Division |
And 4 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012
Deficiency of vitamin B12 and folate is associated with causation of certain precancerous conditions and cancer. The present study was carried out on 56 controls, 167 patients with oral precancerous conditions (OPC) and 214 head and neck cancer patients, to evaluate the plasma vitamin B12 and folate levels to determine their association with tobacco habits and vegetarianism and several sociodemographic factors. The subjects were interviewed using a health habit and diet questionnaire at the time of blood collection. Simultaneous estimations of plasma vitamin B12 and folate were done by Dual Count Radioassay. It was found that the habit of tobacco consumption, lower education and low income were among the risk factors. A decrease in the plasma vitamin B12 and folate levels with respect to tobacco habits, disease progression, and vegetarian diet was also observed. The individuals in the ower quartile for vitamin B12 and folate were at a higher risk of developing OPC, as compared to those in higher quartiles. Similarly, the patients with OPC in lower quartiles were found to be at a higher risk of developing cancer than their counterparts. There was a significant positive correlation between vitamin B12 and folate levels in the subjects consuming tobacco, and more so in patients with OPC (r=0.4330, p=0.000). Folate levels were significantly lower in patients with advanced as compared with early disease (ANOVA p=0.006 and Spearman's Rho = -0.211 and p=0.01). The results suggest, potential significance of plasma vitamin B12 and folate levels in head and neck malignancies which needs to be confirmed by further studies on a large population.
Ko-Ko-Zaw,Epidemiology Research Division |
Tint-Swe-Latt,Yangon University |
Phyu-Phyu-Aung,Nutrition Research Division |
Thein-Gi-Thwin,Biochemistry Research Division |
Tin-Khine-Myint,Nutrition Research Division
Asia-Pacific Journal of Public Health | Year: 2011
A study was performed among 4616 people aged 20 years and above in Yangon Division in 2003 to determine the prevalence of hypertension and its associated factors. The prevalence of hypertension (systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or use of antihypertensive drugs) was 33.8% (95% confidence interval [CI] = 32.1%-35.6%). The prevalence of prehypertension (systolic blood pressure = 120 to 139 mm Hg or diastolic blood pressure = 80 to 89 mm Hg) was 29% (95% CI = 27.2%-30.8%). The multiple logistic regression showed that age, low physical activity, high intake of alcohol, obesity, high level of total cholesterol, and diabetes mellitus were associated with hypertension. Among the hypertensive participants, 53% were aware of their hypertension, and 32% were currently taking antihypertensive medication, but only 11% had their hypertension controlled. The study highlights the low level of control despite the high level of hypertension prevalence in Yangon Division. © 2011 Asia-Pacific Journal of Public Health.