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Parizadeh S.A.,Biochemistry of Nutrition Research Center | Jamialahmadi K.,Biotechnology Research Center | Rooki H.,Neyshabur University of Medical science | Mirhafez S.R.,Mashhad University of Medical Sciences | And 6 more authors.
Annals of Nutrition and Metabolism

Conclusions: This study suggests that the rs16147 polymorphism in the NPY gene may not be a potential contributor to the risk of CAD in an Iranian population.Background/Aims: Several genetic factors have been identified that may contribute to the risk of coronary artery disease (CAD). Variants of the neuropeptide Y (NPY) gene, whose products play an important role in regulating several physiological functions, have been associated with the risk of CAD in some populations. The purpose of this study was to investigate the relationship between the NPY gene rs16147 polymorphism and the presence of CAD in an Iranian population.Methods: DNA samples of 922 subjects, including 433 with angiographically defined CAD (CAD+), 196 without angiographically defined significant CAD (CAD-) and 293 controls, were genotyped using polymerase chain reaction based on the amplification-refractory mutation system. Logistic regression analyses were performed to assess the association of rs16147 genotypes with the presence of significant CAD.Results: Although logistic regression analysis indicated that the NPY polymorphism rs16147 was nominally associated with an increased risk of CAD (p < 0.05), after adjustment for confounding factors, there was no evidence for any significantly increased or decreased risk of CAD with this polymorphism. However, in stratified analyses, the C allele was significantly associated with a reduced risk of CAD in males and subjects who were <50 years of age. © 2014 S. Karger AG, Basel. Source

Darbandi S.,Mashhad University of Medical Sciences | Darbandi M.,Mashhad University of Medical Sciences | Mokarram P.,Shiraz University of Medical Sciences | Owji A.-A.,SUMS | And 13 more authors.
Alternative Therapies in Health and Medicine

Background The prevalence of obesity, a major public health problem, is increasing in many countries, including Iran. Leptin, a peptide hormone that is released from adipocytes, is a major factor in appetite regulation. Levels of plasma leptin increase with increased body fat mass (BFM). Research has found acupuncture to be effective both in weight loss and suppression of appetite. Although a few studies have reported the effect of body and ear acupuncture on leptin levels, researchers have performed few studies on the effect of body electroacupuncture in humans. Objective The research team examined the effects of body electroacupuncture and a low-calorie diet on plasma leptin in obese and overweight individuals with an excess (phlegm-dampness or phlegm-heat) or deficiency (spleen/ stomach qi deficiency or primary qi deficiency) pattern according to Chinese medicine. Design The research team randomly assigned participants to one of two groups, intervention or control. Setting This study occurred in the nutritional clinic at Ghaem Hospital in Mashhad, Iran. Participants Participants were individuals (N = 86) between 18 and 65 years of age with body mass indexes (BMI) between 25 and 45 kg/m2. Intervention The intervention group (n = 47) received actual electroacupuncture, and the control group (n = 47) received sham acupuncture. Both groups consumed a low-calorie diet for 6 weeks. Outcome Measures The research team measured plasma leptin, BFM, body weight (BW), and BMI before and after treatment. Results For participants in the intervention group with both the excess and the deficiency patterns, the research team found a significant reduction in plasma leptin (24.96%, P =.001) and BFM (8.29%, P =.001). In the control group, the team found a less significant reduction in leptin and BFM. The difference between the two groups was significant for leptin (P =.03) but not for BFM (P =.8). Conclusions While body electroacupuncture with a low-calorie diet can reduce plasma leptin concentration, the mechanism will require further clarification. Source

Rahsepar A.A.,Biochemistry of Nutrition Research Center | Mirzaee A.,Mashhad University of Medical Sciences | Moodi F.,Mashhad University of Medical Sciences | Moohebati M.,Mashhad University of Medical Sciences | And 13 more authors.
Medical Principles and Practice

Objective: To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty. Subjects and Methods: A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. Results: In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease. Conclusions: Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG. © 2015 S. Karger AG, Basel. Source

Parizadeh S.A.,Biochemistry of Nutrition Research Center | Jamialahmadi K.,Biotechnology Research Center | Jamialahmadi K.,Mashhad University of Medical Sciences | Rooki H.,Shahid Beheshti University of Medical Sciences | And 8 more authors.
Annals of Human Biology

Background and aims: There have been few epidemiological studies that have investigated genetic susceptibility to cardiovascular risk associated with the prevalence of metabolic syndrome (MetS). Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). Therefore, the aim of this study was to investigate the association between the NPY gene rs16147 polymorphism and the presence of MetS in a well defined group of Iranian subjects with angiographically-defined CAD. Methods: A cross-sectional study design was used in which a total of 364 patients were recruited; 143 patients with MetS and 221 without MetS were genotyped using the ARMS-PCR technique. Logistic regression analyses were performed to determine the odds ratios (ORs) for the association of specific genotypes with the presence of MetS and related phenotypes. Results: The frequency of the variant G allele of the NPY gene was significantly higher in CAD patients without MetS (p=0.032). Compared to the AA genotype of the NPY gene, individuals carrying the GG genotype had a reduced risk of MetS (OR=0.51, 95% CI=0.27-0.95, p=0.034). Conclusion: The rs16147 polymorphism may be associated with presence of MetS among subjects with documented CAD. Carriage of NPY A allele in patients with CAD is associated with a higher prevalence of MetS. © 2014 Informa UK Ltd. All rights reserved. Source

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