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Rahsepar A.A.,Mashhad University of Medical Sciences | Rahsepar A.A.,Biochemistry and Nutrition Research Center | Pourghadamyari H.,Mashhad University of Medical Sciences | Pourghadamyari H.,Biochemistry and Nutrition Research Center | And 20 more authors.
Clinical Biochemistry | Year: 2011

Objective: We have measured the pro-oxidant-antioxidant-balance (PAB) levels in patients with defined coronary artery disease (CAD) and compared them with concentrations in healthy subjects. Design and methods: Based on angiography results, 400 patients with stable CAD were divided into CAD- and CAD+, this being further subcategorized into groups with single-, double- and triple-vessel disease (VD). Results: The mean PAB values in the healthy subjects, was significantly lower than for other groups (P<. 0.001). In CAD- patients, PAB levels were 123.2 ± 43.9, which was not statistically different compared to groups with SVD, 2VD and 3VD (P>. 0.05). In the CAD+ group, PAB values in 1VD, 2VD and 3VD were not significantly different among patients with SVD, 2VD and 3VD (P>. 0.05). Conclusions: In conclusion, we found higher levels of oxidative stress in CAD+ patients compared to healthy subjects. The oxidation level was not related to measures of the extent of CAD such as number of stenosed vessels. © 2011 The Canadian Society of Clinical Chemists. Source


Rahsepar A.A.,Mashhad University of Medical Sciences | Rahsepar A.A.,Biochemistry and Nutrition Research Center | Rahsepar A.A.,Islamic Azad University at Mashhad | Mirzaee A.,Mashhad University of Medical Sciences | And 19 more authors.
Angiology | Year: 2012

We studied the immune responses to heat shock protein (Hsp)-27 and pro-oxidant-antioxidant balance (PAB) values in patients with valvular heart disease, but free of angiographically evident coronary artery disease (CAD). Patients who were candidates for valvuloplasty surgery and 30 healthy matched controls were recruited. The anti-Hsp-27 antibody titers were 0.35 ± 0.04 absorbency units (AU) in the valvuloplasty group, being significantly higher than for the controls (0.11 ± 0.02 AU; P <.05). The PAB values were significantly higher in cases (134.67 ± 13.69 Hamidi-Koliakos(HK) unit) when compared with controls (49.78 ± 6.75 HK unit; P <.05). In cases, the ejection fraction was inversely correlated with anti-Hsp-27 antibody (P <.05) but was not significantly related to PAB values (P >.05). Based on the echocardiographic findings, the patients had no evident heart failure, but the high levels of anti-Hsp-27 and PAB values in patients with valvular heart disease may indicate that these variables can be used as markers of heart failure. However, a longitudinal study is required to confirm this hypothesis. © The Author(s) 2012. Source


Tavallaie S.,Mashhad University of Medical Sciences | Rahsepar A.A.,Mashhad University of Medical Sciences | Rahsepar A.A.,Biochemistry and Nutrition Research Center | Rahsepar A.A.,Islamic Azad University at Mashhad | And 9 more authors.
Clinical Biochemistry | Year: 2012

Objectives: We have assessed the relationship between indices of adiposity and antibody titers to Hsp-27 in healthy subjects. Design: Two-hundred and fifty subjects were studied, including 50 normal-weight subjects (body-mass-index (BMI) [U+02C2]25kg/m 2), 100 overweight subjects (BMI 25 to [U+02C2]30kg/m 2) (n=100) and 100 obese subjects (BMI ≥30kg/m 2). Results: Anti-Hsp27-antibody levels in obese subjects were [0.34 (0.20-0.39) absorbency unit], being significantly higher than overweight and normal-weight groups (P< 0.05). Anti-Hsp27-antibody levels in overweight subjects [0.29 (0.15-0.34) absorbency unit] were statistically higher than controls [0.18 (0.10-0.23) absorbency unit] (P< 0.05). Conclusion: High anti-Hsp-27-antibody levels in obese-subjects without established coronary disease may be related to a heightened state of immunoactivation associated with obesity. © 2011 The Canadian Society of Clinical Chemists. Source

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