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Mansourian A.R.,Biochemistry and Metabolic Disorder Research Center
Pakistan Journal of Biological Sciences | Year: 2010

The immune system protect individual from many pathogens exists within our environment and in human body, by destroying them through molecular and cellular mechanism of B and T cells of immune system. Autoimmunity is an adverse relation of immune system against non- foreign substances leaving behind either alters the normal function or destroying the tissue involved. Autoimmunity occur in genetically predispose persons with familial connections. The autoimmunity to the thyroid gland mainly consists of Hashimato thyroiditis and Grave's disease, the two end of spectrum in thyroid function of hypo and hyperactivity, respectively. The thyroid stimulating hormone receptor, thyroglobuline, enzymes of thyroid hormones synthesis are targeted by autoantibodies and cell- mediated reactions. The aim of this review is to explore the studies reported on the autoimmunity to the thyroid gland. © 2010 Asian Network for Scientific Information. Source

Mansourian A.R.,Biochemistry and Metabolic Disorder Research Center
Pakistan Journal of Biological Sciences | Year: 2010

Hypothyroidism, is a thyroid disorder accompanied by serum thyroid hormone reduction when thyroxin T4, the main thyroid hormone, reduced, it is followed by disruption of a negative-feed back auto regulatory mechanism on pituitary gland and subsequent thyroid stimulating hormone (TSH) which is released into the blood circulation to stimulate the thyroid gland to produce enough thyroid hormone to compensate for the body hormone requirements. Therefore, reduced serum thyroxin (T4) in principle, triidothyronine (T3) and elevated TSH are laboratory indices for the diagnosis of hypothyroidism. At early stage of hypothyroidism although laboratory measurements of thyroid function test are manifest the thyroid disorder but the patient clinical signs and symptoms may remain unnoticed. If the patient undiagnosed and untreated the condition of hypothyroidism worsen and the clinical manifestation begin to show itself and myxedema is a definition given to the whole picture of untreated hypothyroidism at very end stage the patients enter into myxedema comma with eventual death due to the sever symptoms of hypothyroidism. Among important causative factors leading to catastrophic events in myxedema is life threatening hypothermia, heart and cerebral dysfunctions. © 2010 Asian Network for Scientific Information. Source

Mansourian A.R.,Biochemistry and Metabolic Disorder Research Center | Ahmadi A.R.,Golestan University of Medical Sciences
Journal of Clinical and Diagnostic Research | Year: 2010

The aim of this research was to investigate whether serum thyroxin concentration, within the normal reference intervals were age-related among children and adolescents. This investigation was carried out on 243 subjects who were chosen randomly from all those patients who were referred during the one-year period from to the Danesh Medical Diagnostic Laboratory in Gorgan, northern Iran. The thyroxin concentrations of the subjects were obtained from the outpatient records of the patients who were referred to the Laboratory during 2007-08. The thyroxin concentrations were determined by the Radio Immunoassay method by using standard laboratory kits. The sample population were divided into 4 age groups of 1-5 years, 6-10 years, 11-15 years and 16-21years. The results of this study showed that there is an inverse age correlation between thyroxin concentrations among children and adolescents in this region. Source

Marjani A.,Biochemistry and Metabolic Disorder Research Center | Rahmati R.,Golestan University of Medical Sciences | Mansourian A.R.,Biochemistry and Metabolic Disorder Research Center | Veghary G.,Biochemistry and Metabolic Disorder Research Center
Open Biochemistry Journal | Year: 2012

This study was undertaken to determine the influences of various doses of peppermint oil on the hepatic enzymes, alanine transaminase, apartate tranaminase, alkaline phosphotase and gamma glutamyl transferase and the level of malondialdehyde in the serum of mice with and without immobility stress. The mice exposed to drink water, 0.9, 27 and 60 mg/kg peppermint oil from the days 1 to 5 for a period of 4 h before and after immobility stress. Serum MDA increased in treatment group II, III and IV after immobility stress. There was a significant decrease in ALT in treatment group III and IV after immobility stress. There were also significant decreases in ALP and GGT in treatment group IV after immobility stress. This result may suggest that, MDA level is higher in immobilization stress group than in the un-immobilized animals in serum and this results show that enzyme activities decreased after immobilization stress. © Marjani et al. Source

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