Lausanne, Switzerland
Lausanne, Switzerland
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Cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample. The cartridge includes one or more nucleic acid sequences, wherein the cartridge has a generic part and one or more separate application-specific parts, which are connectable to the generic part.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.3.3-1 | Award Amount: 31.38M | Year: 2014

Far from receding, the threats posed by infections with epidemic potential grow ever greater. Although Europe has amongst the best healthcare systems in the world, and also the worlds supreme researchers in this field, we lack co-ordination and linkage between networks that is required to respond fast to new threats. This consortium of consortia will streamline our response, using primary and secondary healthcare to detect cases with pandemic potential and to activate dynamic rapid investigation teams that will deploy shared resources across Europe to mitigate the impact of future pandemics on European health, infrastructure and economic integrity. If funded, PREPARE will transform Europes response to future severe epidemics or pandemics by providing infrastructure, co-ordination and integration of existing clinical research networks, both in community and hospital settings. It represents a new model of collaboration and will provide a one-stop shop for policy makers, public health agencies, regulators and funders of research into pathogens with epidemic potential. It will do this by mounting interepidemic (peace time) patient oriented clinical trials in children and in adults, investigations of the pathogenesis of relevant infectious diseases and facilitate the development of sophisticated state-of-the-art near-patient diagnostics. We will develop pre-emptive solutions to ethical, administrative, regulatory and logistical bottlenecks that prevent a rapid response in the face of new threats. We will provide education and training not only to the members of the network, but also to external opinion leaders, funders and policy makers thereby streamlining our future response. By strengthening and integrating interepidemic research networks, PREPARE will enable the rapid coordinated deployment of Europes elite clinical investigators, resulting in a highly effective response to future outbreaks based on solid scientific advances.


The invention relates to a design of an interface plate (101) between a microfluidic cartridge (100) and an instrument (102) for fluid actuation in the disposable cartridge. Pneumatic actuation is carried out through a reversible pneumatic interconnection between instrument and cartridge. Pneumatic drivers are integrated in the instrument for a low cost and reliable solution. The actuation of the fluid in the cartridge is achieved by a flexible membrane (105) attached to the major surface of the disposable cartridge forming closed compartments only when attached to the instrument. The pressure, in these compartments determines the deflection of the membrane which in turn actuates the fluid. This approach takes advantage of the high power and large stroke of pneumatic actuation while at the same time keeping the disposable cartridge simple and low cost and allowing easy introduction of other physical transport across the interface plate, like heat or acoustic vibration. A large number of actuators can be integrated easily into the flat interface plate as no individual fixation, like tubing, is required for the pneumatic actuation.


Disclosed is a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step. Also disclosed is an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscope or labelling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers.


Patent
Biocartis | Date: 2014-01-15

System for performing biological analysis comprising:- a cartridge (20) having a deformable chamber (24) suitable for containing a liquid to be analyzed;- a heater (15) having a heating face arranged to heat the liquid contained in the deformable chamber (24);characterized in that the heating face of the heater (15) is moveable from a first position to at least a second position, different from the first position, to allow an increase of volume of said deformable chamber (24) in order to compensate an increase of pressure in the deformable chamber (24) during the heating of said liquid by said heater.


Patent
Biocartis | Date: 2016-10-12

The invention relates to a manifold system comprising a manifold housing and a manifold core. Means of using an oblique surface inside of the manifold housing onto which a manifold core is to be inserted and by adapting a fluidic channel in the manifold housing the corresponding way, such a manifold housing is producible by manifold casting without having an undercut. Thus, the use of sliders during production of such a manifold housing is avoided. Any need for applying external forces (e.g. by an instrument) for obtaining a seal between the manifold housing and the manifold core is obviated.


The method according to the invention consists in providing a wafer (15) having a bottom layer (16), a top first sacrificial layer (17) and an insulating layer (18), structuring the first sacrificial layer (17) to form a three dimensional structure onto which a first structural layer is deposited to define a corresponding three dimensional structure on the bottom surface of the first structural layer. The method consists also in forming a second three dimensional structure on the upper surface of the first structural layer.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.86M | Year: 2016

Infectious diseases are a major burden to public health and the global economy, not in the least due to antimicrobial resistance. Rapid point of care (POC) in vitro diagnostics (IVD) are key tools in the effective clinical management of patients with infectious diseases. Yet there is still a large unmet clinical need for more rapid POC IVDs generating more clinically relevant, actionable information. Effectively addressing this need requires a change in the current approach in training researchers on IVDs, generating a new breed of IVD researchers capable of closing the gap between the clinical and technological perspective. ND4ID takes up this challenge by offering 15 ESRs a world-class first of its kind training programme where they will be exposed to the full breadth of disciplines spanning clinical, technological and market-oriented viewpoints, from both the academic and non-academic sector. Through a set of synergistic research projects on novel POC assays, targeting the most important and urgent clinical needs at world leading academic or private sector research groups, the ESRs are offered a holistic training program, preparing them to be lead players in the future IVD field. This training through research is augmented by a unique comprehensive network-wide training programme covering clinical, technical and translational knowledge and skills of relevance to IVD research, development and exploitation. As such, ND4ID will deliver ESRs that will be in high demand serving as an example for other academic and non-academic actors active in training IVD researchers and further strengthening Europes position in the internally competitive arena of IVD technology.


Patent
Biocartis | Date: 2014-10-29

The present invention relates to a method for quantifying at a functional group (1) functionalizing a surface (2). First, the method comprising the step of providing at a surface (2) having micrometric dimensions functionalized with at a functional group (1). The method includes a step of contacting the surface (2) with a solution: Said solution comprises at a first reagent (4) at a first concentration and a second reagent (5) at a second concentration, the ratio between the first concentration and the second concentration being predetermined. Said first reagent (4) and second reagent (5) are designed for selectively coupling to a functional group (2) with respective affinities, the ratio of said affinities being predetermined. The first reagent (4) is labelled for emitting fluorescence and the second reagent (5) is un-labelled. Then, the fluorescence of said first reagent (4) on the surface to quantify said functional group (1) therefrom.


Patent
Biocartis | Date: 2015-02-05

An apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus includes a source for emitting high intensity ultrasound waves and is adapted to receive a cartridge having a chamber containing the liquid sample, wherein the high intensity ultrasound waves are focused on a focus position at or near a nucleation element extending at least partially into the chamber.

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