BioBioPha Co.

Kunming, China

BioBioPha Co.

Kunming, China
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Wang G.,Anhui University of Traditional Chinese Medicine | Wang F.,BioBioPha Co. | Wang F.,CAS Kunming Institute of Botany | Liu J.-K.,CAS Kunming Institute of Botany
Molecules | Year: 2011

Two new phenols, 2(S)-2',7-dihydroxy-5,8-dimethoxyflavanone (1) and (S)-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydro-4H-pyran-4-one (2), were isolated from the ethanol extract of Scutellaria barbata. Their structures were elucidated on the basis of spectroscopic analysis. © 2011.


Wang F.,CAS Kunming Institute of Botany | Wang F.,CAS Shanghai Institutes for Biological Sciences | Gao Y.,CAS Shanghai Institutes for Biological Sciences | Zhang L.,CAS Kunming Institute of Botany | And 6 more authors.
Organic Letters | Year: 2010

(Figure Presented) (+)-Linderaspirone A and (-)-linderaspirone A, a pair of natural windmill-shaped enantiomers, were isolated from the traditional Chinese medicine plant Lindera aggregate by HPLC using a chiral column, achieving over 98% ee. Their structures and absolute configurations were determined on the basis of extensive analysis of NMR spectra, crystal X-ray diffraction, and calculation of the optical rotations (OR). They have an unprecedented carbon skeleton and showed significant activity against glucosamine-induced insulin resistance. © 2010 American Chemical Society.


Gao Y.,CAS Kunming Institute of Botany | Gao Y.,BioBioPha Co. | Gao Y.,University of Chinese Academy of Sciences | Wang G.-Q.,CAS Kunming Institute of Botany | And 5 more authors.
Organic Letters | Year: 2012

(±)-Guajadial B (1), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive analysis of NMR spectra and confirmed by biomimetic synthesis in a domino three-component coupling reaction. © 2012 American Chemical Society.


Wang F.,CAS Kunming Institute of Botany | Wang F.,BioBioPha Co. | Ren F.-C.,BioBioPha Co. | Liu J.-K.,CAS Kunming Institute of Botany
Chemical and Pharmaceutical Bulletin | Year: 2010

Four new neo-clerodane diterpenoids, scutebarbatines W-Z (1-4), were isolated from the ethanol extract of Scutellaria barbata (Labiatae), and their structures were elucidated on the basis of extensive spectroscopic studies. In addition, the proposed structures of at least seven 13-spiro subtype neo-clerodanes: scutehenanine B (5), scutebarbatine G (6), 6-O- nicotinoylscutebarbatine G (7), barbatin A (8), 6,7-di-O- nicotinoylscutebarbatine G (9), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (10), and scutebarbatine F (11), reported by Dai and co-workers from the same species, were incorrectly assigned and have been revised by reanalysis of the published NMR data. © 2010 Pharmaceutical Society of Japan.


Wang F.,CAS Kunming Institute of Botany | Wang F.,BioBioPha Co. | Zhou D.-S.,BioBioPha Co. | Wei G.-Z.,BioBioPha Co. | And 2 more authors.
Phytochemistry | Year: 2012

Six eudesmane-type sesquiterpene lactones, named chlorantholides A-F, were isolated from the ethanol extract of Chloranthus elatior (Chloranthaceae) together with 12 known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis, and their absolute configurations were studied by the CD exciton chirality method. The structure of a recently reported eudesmanolide from Chloranthus anhuiensis: 8β-hydroxy-1-oxoeudesma-3,7(11) -dien-12,8-olide, was also revised as 8β-hydroxy-2-oxoeudesma-3,7(11)-dien- 12,8-olide (chlorantholide D). © 2011 Elsevier Ltd. All rights reserved.


Wang F.,CAS Kunming Institute of Botany | Wang F.,BioBioPha Co. | Mao M.-F.,BioBioPha Co. | Wei G.-Z.,BioBioPha Co. | And 3 more authors.
Phytochemistry | Year: 2013

Two Daphniphyllum alkaloid and iridoid hybrids with the hitherto unknown decacyclic fused skeletons, hybridaphniphyllines A and B, along with one diamino Daphniphyllum alkaloid, daphnicyclidin I, were isolated from dried stems and leaves of Daphniphyllum longeracemosum. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of daphnicyclidin I was deduced by the CD exciton chirality method. A biogenetic pathway for 1 and 2 involving natural Diels-Alder cycloaddition is proposed. © 2013 Elsevier Ltd. All rights reserved.


Wang F.,CAS Kunming Institute of Botany | Wang F.,BioBioPha Co. | Gao Y.,BioBioPha Co. | Zhang L.,CAS Kunming Institute of Botany | Liu J.-K.,CAS Kunming Institute of Botany
Organic Letters | Year: 2010

Bi-linderone (1) was isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. The structure elucidation of bi-linderone was reported on the basis of extensive analysis of NMR spectra and crystal X-ray diffraction. Bi-linderone has an unprecedented spirocyclopentenedione-containing carbon skeleton and showed significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 μg/mL. © 2010 American Chemical Society.


PubMed | BioBioPha Co.
Type: Journal Article | Journal: Natural products and bioprospecting | Year: 2015

Four hitherto unknown 6a,11b-dihydroxypterocarpans, namely pterocarpadiols A-D (1-4), were isolated from the ethanol extract of the twigs and leaves of Derris robusta. Their structures were elucidated on the basis of extensive spectroscopic analysis. Pterocarpadiols A-D are a kind of very rare 6a,11b-dihydroxypterocarpans, and their presence as markers may be helpful in chemotaxonomical classification.


PubMed | BioBioPha Co.
Type: Journal Article | Journal: Natural products and bioprospecting | Year: 2016

Four hitherto unknown prenylated coumarins, namely 6-O--D-apiofuranosylapterin (1), 4-O-isobutyroylpeguangxienin (2), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (3), and 6-hydroxycoumurrayin (4), were isolated from the ethanol extract of Heracleum stenopterum, Peucedanum praeruptorum, Clausena lansium, and Murraya paniculata, respectively. Their chemical structures were established on the basis of extensive spectroscopic analysis. Compound 2 exhibited in vitro cytotoxic activity against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480) with IC


PubMed | BioBioPha Co.
Type: Journal Article | Journal: Natural products and bioprospecting | Year: 2016

Four hitherto unknown prenylated isoflavonoids, named derrisisoflavones H-K (1-4) and one new isoflavan, namely 6-hydroxyisosativan (5), were isolated from the ethanol extract of Derris robusta. Their structures were elucidated on the basis of extensive spectroscopic studies. To our knowledge, derrisisoflavones J (3) and K (4) are the first examples of hydroxyethylated isoflavonoid.

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