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Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-1 | Award Amount: 2.23M | Year: 2010

The activity of genes is absolutely essential for all life from viruses and bacteria to crops and human beings. Despite the many technological breakthroughs within life science research during the last 20-30 years, we are however still far away from fully understanding the activity of genes and which factor influence (regulates) the gene activity. Such knowledge is, by nature, of very high importance and very high value to life science researchers globally, and the ANGS project consortium will therefore develop a suite of algorithms, methods, and software tools that are significantly better at analyzing and understanding gene regulation than what exists today. The consortium consists of three SMEs that all are poised to take advantage of the new developments in genome sequencing (CLC bio, BIOBASE, and deCODE genetics), and 4 academic partners (Oxford University, Goettingen University, Renyi Institute, and NCSB). The SMEs will commercialize the results to help ensure that EU companies are established among the world leaders within solutions for analysis of gene regulation. The primary focus of the consortium will be to develop methods for including the massive amounts of genomic data that is being generated using the revolutionary Next Generation Sequencing technologies an amount of data that will increase exponentially in the coming years, and that is virtually impossible to analyze with any reasonable success by existing methods and in existing software. The software suite, the ANGS engine will thus make it possible to include up to a thousand genomes, e.g. from the 10,000 genome project as knowledge input in gene regulation analysis. Such software will be able to provide completely new knowledge and will thus have tremendous value to life science researcher globally, including pharmaceutical companies, biotech companies, agricultural companies, biofuel companies, research hospitals, as well as universities and governmental research organizations

Biobase Gmbh and Biological Databases Biologische Datenbanken Gmbh | Date: 2006-09-12

Computer software and downloadable computer software, all in the field of gene regulation and molecular biology for medical, scientific and research applications, that may be downloaded from a global computer network. Technical consultation and research in the field of gene regulation and molecular biology; computer services, namely services providing an on-line computer database in the field of gene regulation and molecular biology.

Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-ITN-2008 | Award Amount: 1.91M | Year: 2009

We will educate and train young scientists to apply an interdisciplinary systems-based approach to complex biological questions using plant reproduction as a model system. Systems approaches are not routinely taught, have been identified as an area requiring urgent PhD-level training in some European countries and require network-scale working practices. We have assembled a team with International research reputations in two key areas for the success of this project: half are experimental and half are computational/mathematical scientists. We will place 9 PhD students under the supervision of this team, focussed on this single biological problem. Students assigned to experimental groups will use advanced techniques to generate data for the computational groups. The computational students will inform, analyse, interpret and model the data and their models will be validated by the experimental groups. A series of laboratory placements will ensure a wide range of subject-specific training and exchanges between the experimental and computational groups will lead to a greater understanding at the interface of these disciplines. The integration of a team of PhD students into this project, so that they each see their contributions as essential and integral parts of the success of the strategy, combined with the supervison and co-ordinated discipline-specific and generic training schedule will produce a cohort of young scientists trained in systems biology. The core skills and approaches that will be instilled into the young scientists and the integration of industry into the project, will equip them to take a systems approach to any biological question and prepare them for a career in an academic or industrial environment. Scientific outcomes will include the use of advanced techniques to provide the quantity and quality of data required to model floral regulation, the use of computational approaches to generate predictive models and their experimental validation.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.35M | Year: 2015

ENLIGHT-TEN is a European Network Linking Informatics and Genomics of Helper T cells: our mission is to provide cross-disciplinary training in cellular immunology and big data analysis such that we train a new generation of researchers to fully exploit the power of emerging technological platforms. Our network of TEN beneficiaries combines T cell expertise with state-of-the-art technologies such as next generation sequencing (NGS), bioinformatics, multi-colour flow cytometry, preclinical models and tailored genome editing. Trainees will acquire a comprehensive knowledge in T cell immunology and the capacity to generate and interrogate big data sets as well as expertise in identifying novel biomarkers and developing therapeutic concepts. As such the training programme will provide an ideal stepping-stone for creative and innovative early stage researchers (ESRs) to enter and strengthen Europes academia as well as pharmaceutical and bioinformatics companies. The research focus of the network lies in the identification of extrinsic and intrinsic factors that control development, differentiation and plasticity of helper T cell subsets with particular emphasis on how T cell differentiation impacts on human diseases. The generation of large data sets is an emerging and challenging field, and there is high demand in both the academic sector as well as pharmaceutical companies for researchers to be able to analyse, integrate and exploit this rich source of information. ENLIGHT-TEN will combine the individual strengths of innovative laboratories and enterprises from complementary disciplines to provide unique interdisciplinary training for 13 ESRs, placing them at the forefront of this emerging field. Trainees will be empowered to perform cutting-edge analysis of the steadily increasing number of different T cell subsets, which play highly diverse and critical roles in the development of autoimmune diseases, making them a key target for pharmaceutical companies.

Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2007-2.1.1-6 | Award Amount: 16.02M | Year: 2008

Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quantification of alterations of the total lipid profile after specific perturbations. In combination with advanced proteome and transcriptome analysis tools and novel imaging techniques using RNA interference, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. This project application of the European Lipidomics Initiative (ELife; www.lipidomics.net) will address lipid droplets (LD) as dynamic organelles with regard to composition, metabolism and regulation. LD are the hallmark of energy overload diseases with a major health care impact in Europe. The project will exploit recent advances in lipidomics to establish high-throughput methods to define drugable targets and novel biomarkers related to LD lipid and protein species, their interaction and regulation during assembly, disassembly and storage. Translational research from mouse to man applied to LD pathology is a cornerstone of this project at the interface between research and development. To maximize the value of the assembled data generated throughout the project, LipidomicNet as a detailed special purpose Wiki formate data base will be developed and integrated into the existing Lipidomics Expertise Platform (LEP) established through the SSA ELife project (www.lipidomics-expertise.de). ELife collaborates with the NIH initiative LIPID MAPS (www.lipidmaps.org) and the Japanese pendant Lipidbank (www.lipidbank.jp) and is connected to the Danubian Biobank consortium (SSA DanuBiobank, www.danubianbiobank.de) for clinical lipidomics.

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