Bioactive Organic Molecule Synthetic Unit

Melvisharam, India

Bioactive Organic Molecule Synthetic Unit

Melvisharam, India
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Ramadoss H.,Bioactive Organic Molecule Synthetic Unit | Kiyani H.,Damghan University | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit
Iranian Journal of Chemistry and Chemical Engineering | Year: 2017

Triphenyl phosphine (PPh3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4H-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in EtOH-H2O (1:1) at reflux conditions. The results show that aromatic aldehydes containing electron-donating groups or electron-withdrawing groups could react smoothly to give the corresponding products in good to excellent yields. Given the increasing levels of interest in green chemistry, the recyclability and reusability of the catalyst have been evaluated. It was also found that triphenyl phosphine can be recycled at least four times without loss of activity. This method has the advantages of high yield, mild reaction conditions, environmentally benign methodology and short reaction time. © 2016, Jihad Danishgahi. All Rights Reserved.


Ghashang M.,Islamic Azad University at Najafabad | Guhanathan S.,Muthurangam Government Arts College | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2017

A highly efficient multi-component reaction of structurally diverse aryl aldehydes, 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione and 1H-indene-1,3(2H)-dione using nano Fe2O3@SiO2–SO3H as a catalyst is described. The products are a variety of indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione derivatives. The effect of the solvent on the product selectivity was investigated. The morphology, particle size distribution, and some properties of Fe2O3@SiO2–SO3H nanopowders have been characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray powder diffraction (XRD), N2 adsorption–desorption isotherms and thermogravimetric analysis (TGA) techniques. © 2017 Springer Science+Business Media B.V.


Ramadoss H.,Bioactive Organic Molecule Synthetic Unit | Saravanan D.,Bioactive Organic Molecule Synthetic Unit | Sudhan S.P.N.,Bioactive Organic Molecule Synthetic Unit | Sheik Mansoor S.,Bioactive Organic Molecule Synthetic Unit
Der Pharmacia Lettre | Year: 2016

A series of novel spirooxindole derivatives have been synthesized from isatin, malononitrile, and cyclic 1,3-dicarbonylcompounds through a highly efficient and green one-pot multicomponent reaction using tetrabutylammonium bromide (TBAB) as catalyst in ethanol under reflux condition. The synthesized compounds were evaluated for their antimicrobial activity. Antimicrobial studies showed that all the target compounds processing good antibacterial and antifungal activities.


Shafiee M.R.M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Ghashang M.,Islamic Azad University at Najafabad | Fazlinia A.,Islamic Azad University
Comptes Rendus Chimie | Year: 2014

Various derivatives of 3,4,5-substituted furan-2(5H)-ones have been readily prepared by using aluminum hydrogen sulfate [Al(HSO4)3] as an efficient catalyst in good yields and milder reaction conditions. The versatility of this protocol has been demonstrated with various substituted furan-2(5H)-ones. © 2013 Académie des sciences.


Polyvinylpolypyrrolidone-supported triflic acid (PVPP.OTf) has been used as a recyclable catalyst for synthesis of a series of 7-hydroxy-10-aryl-10H-indeno[1,2-b]chromen-11-one derivatives by condensation of aldehydes, resorcinol, and 2H-indene-1,3-dione. 13-Phenylindeno[1,2-b]naphtho[1,2-e]pyran-12(13H)-one and 12-phenyl-12H-indeno[1,2-b]naphtho[3,2-e]pyran-5,11,13-trione were also synthesized by condensation of benzaldehyde, β-naphthol or 2-hydroxynaphthalene-1,4-dione, and 2H-indene-1,3-dione with PVPP.OTf as catalyst. The heterogeneous catalyst was used for four runs. This method has the advantages of high yields, simple methodology, short reaction times, and easy work-up. © 2015 Springer Science+Business Media Dordrecht.


Ghashang M.,Islamic Azad University at Najafabad | Aswin K.,Bioactive Organic Molecule Synthetic Unit | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2014

A facile and environmentally benign synthesis of some 2-amino-6-(2-oxo-2H- chromen-3-yl)-4-arylnicotinonitrile derivatives from the reaction of 3-acetylcoumarin, aromatic aldehydes, and malononitrile under solvent-free condition in the presence of silica-supported perchloric acid (HClO 4-SiO2) is described. The ability to reuse the catalyst, the high yields, and ease of purification are the important features of this process. © Springer Science+Business Media Dordrecht 2013.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Cuihua Xuebao/Chinese Journal of Catalysis | Year: 2014

A series of pyrano[4, 3-b]pyran derivatives have been synthesized in excellent yields by the reaction of aromatic aldehydes with malononitrile or cyanoacetate and 4-hydroxy-6-methylpyran-2-one in water at 80°C, with the transformation being catalyzed by an aqueous solution of thiourea dioxide (TUD). Upon completion of the reaction, the product was isolated by filtration or extraction and the remaining aqueous TUD solution could be reused several times without any discernible impact on its catalytic activity. This procedure offers several advantages over existing procedures, including high yields, operational simplicity, the use of a non-toxic catalyst and solvent, short reaction time and minimum pollution of the environment, making it a useful and attractive process for the preparation of pyrano[4, 3-b]pyran derivatives. © 2014, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Cuihua Xuebao/Chinese Journal of Catalysis | Year: 2014

An facile and efficient protocol for the synthesis of 13-aryl-indeno[1, 2-b]naphtha[1, 2-e]pyran-12(13H)-ones has been developed that proceeds via the one-pot three-component sequential reaction of an aromatic aldehyde with β-naphthol and 2H-indene-1, 3-dione under solvent-free conditions in the presence of a poly(4-vinylpyridinium) hydrogen sulfate (P(4-VPH)HSO4) catalyst. The catalyst can be reused several times, making this procedure facile, practical, and sustainable. The simple experimental procedure, solvent-free reaction conditions, use of an inexpensive catalyst, short react time, and excellent yields are some of the major advantages of this methodology. © 2014, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Bulletin of the Korean Chemical Society | Year: 2013

An efficient method for the preparation of 8-benzylidene-4-phenyl-3,4,5,6, 7,8-hexahydro-1H-quinazolin-2- ones/thiones from the reaction of aromatic aldehydes with cyclohexanone and urea or thiourea in the presence of Tetrabutylammonium hexatungstate, [TBA]2[W6O 19], as an efficient, inexpensive catalyst under thermal and solvent-free conditions has been developed. Good yields, short reaction times, straightforward workup, reusability of the catalyst, and green conditions are the most obvious advantages of this procedure.


Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit | Logaiya K.,Bioactive Organic Molecule Synthetic Unit | Sudhan P.N.,Bioactive Organic Molecule Synthetic Unit | Malik S.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2014

A convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery. © 2013 Springer Science+Business Media Dordrecht.

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