Bioactive Organic Molecule Synthetic Unit

Melvisharam, India

Bioactive Organic Molecule Synthetic Unit

Melvisharam, India
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Shafiee M.R.M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Ghashang M.,Islamic Azad University at Najafabad | Fazlinia A.,Islamic Azad University
Comptes Rendus Chimie | Year: 2014

Various derivatives of 3,4,5-substituted furan-2(5H)-ones have been readily prepared by using aluminum hydrogen sulfate [Al(HSO4)3] as an efficient catalyst in good yields and milder reaction conditions. The versatility of this protocol has been demonstrated with various substituted furan-2(5H)-ones. © 2013 Académie des sciences.


Polyvinylpolypyrrolidone-supported triflic acid (PVPP.OTf) has been used as a recyclable catalyst for synthesis of a series of 7-hydroxy-10-aryl-10H-indeno[1,2-b]chromen-11-one derivatives by condensation of aldehydes, resorcinol, and 2H-indene-1,3-dione. 13-Phenylindeno[1,2-b]naphtho[1,2-e]pyran-12(13H)-one and 12-phenyl-12H-indeno[1,2-b]naphtho[3,2-e]pyran-5,11,13-trione were also synthesized by condensation of benzaldehyde, β-naphthol or 2-hydroxynaphthalene-1,4-dione, and 2H-indene-1,3-dione with PVPP.OTf as catalyst. The heterogeneous catalyst was used for four runs. This method has the advantages of high yields, simple methodology, short reaction times, and easy work-up. © 2015 Springer Science+Business Media Dordrecht.


Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Ghashang M.,Islamic Azad University at Najafabad | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2015

Tribromomelamine, has been used as an efficient, inexpensive, and green catalyst for one-pot, three-component synthesis of 7-aryl-8H-benzo[h]indeno[1,2-b]quinoline-8-ones by reaction of 1,3-indanedione, aromatic aldehydes, and 1-naphthylamine under solvent-free conditions. The several advantages of this reaction include high yields, short reaction time, and high catalyst efficiency. © 2014 Springer Science+Business Media Dordrecht.


Ghashang M.,Islamic Azad University at Najafabad | Aswin K.,Bioactive Organic Molecule Synthetic Unit | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2014

A facile and environmentally benign synthesis of some 2-amino-6-(2-oxo-2H- chromen-3-yl)-4-arylnicotinonitrile derivatives from the reaction of 3-acetylcoumarin, aromatic aldehydes, and malononitrile under solvent-free condition in the presence of silica-supported perchloric acid (HClO 4-SiO2) is described. The ability to reuse the catalyst, the high yields, and ease of purification are the important features of this process. © Springer Science+Business Media Dordrecht 2013.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2015

Abstract Efficient synthesis of a novel series of 11-amino-12-aryl-hexahydro-5-oxa-6,13-diaza-indeno[1,2-b]anthracene derivatives has been achieved by cyclocondensation of 2-amino-4,5-dihydro-4-arylpyrano[3,2-b]indole-3-carbonitriles and cyclohexanone in the presence of silica gel-supported aluminium chloride (SiO2-AlCl3) as catalyst under thermal conditions. Thorough optimization of the experimental conditions enabled significant rate enhancement and excellent yields. The starting 2-amino-4,5-dihydro-4-arylpyrano[3,2-b]indole-3-carbonitriles were obtained by one-pot triphenylphosphine-catalyzed multicomponent condensation of 3-hydroxyindole, malononitrile, and aromatic aldehydes. The structures of all the synthesized compounds were established by use of advanced spectroscopic techniques. © 2014 Springer Science+Business Media Dordrecht.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Cuihua Xuebao/Chinese Journal of Catalysis | Year: 2014

A series of pyrano[4, 3-b]pyran derivatives have been synthesized in excellent yields by the reaction of aromatic aldehydes with malononitrile or cyanoacetate and 4-hydroxy-6-methylpyran-2-one in water at 80°C, with the transformation being catalyzed by an aqueous solution of thiourea dioxide (TUD). Upon completion of the reaction, the product was isolated by filtration or extraction and the remaining aqueous TUD solution could be reused several times without any discernible impact on its catalytic activity. This procedure offers several advantages over existing procedures, including high yields, operational simplicity, the use of a non-toxic catalyst and solvent, short reaction time and minimum pollution of the environment, making it a useful and attractive process for the preparation of pyrano[4, 3-b]pyran derivatives. © 2014, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Cuihua Xuebao/Chinese Journal of Catalysis | Year: 2014

An facile and efficient protocol for the synthesis of 13-aryl-indeno[1, 2-b]naphtha[1, 2-e]pyran-12(13H)-ones has been developed that proceeds via the one-pot three-component sequential reaction of an aromatic aldehyde with β-naphthol and 2H-indene-1, 3-dione under solvent-free conditions in the presence of a poly(4-vinylpyridinium) hydrogen sulfate (P(4-VPH)HSO4) catalyst. The catalyst can be reused several times, making this procedure facile, practical, and sustainable. The simple experimental procedure, solvent-free reaction conditions, use of an inexpensive catalyst, short react time, and excellent yields are some of the major advantages of this methodology. © 2014, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.


Ghashang M.,Islamic Azad University at Najafabad | Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Bulletin of the Korean Chemical Society | Year: 2013

An efficient method for the preparation of 8-benzylidene-4-phenyl-3,4,5,6, 7,8-hexahydro-1H-quinazolin-2- ones/thiones from the reaction of aromatic aldehydes with cyclohexanone and urea or thiourea in the presence of Tetrabutylammonium hexatungstate, [TBA]2[W6O 19], as an efficient, inexpensive catalyst under thermal and solvent-free conditions has been developed. Good yields, short reaction times, straightforward workup, reusability of the catalyst, and green conditions are the most obvious advantages of this procedure.


Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Logaiya K.,Bioactive Organic Molecule Synthetic Unit | Sudhan S.P.N.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit
Bulletin of the Chemical Society of Ethiopia | Year: 2015

A new, simple, thermally efficient and solvent-free condensation of 2-amino-4,5-dihydro-4- phenylpyrano[3,2-b]indole-3-carbonitrile derivatives with coumarin-3-carboxylic acid employing succinimide-Nsulfonic acid (SuSA) as catalyst for the synthesis of a series of 5,6-dihydro-2-(2-oxo-2H-chromen-3-yl)-5-phenylindolo[ 2',3':5,6]pyrano[2,3-d]pyrimidin-4(3H)-one derivatives is described. This method has the advantages of high yield, simple methodology, and short reaction time, as well as being green in terms of avoiding the use of toxic catalysts and solvents. Furthermore, the catalyst could be recycled and reused four times without significant loss of activity. Thiourea dioxide (TUD) catalyzed efficient three-component coupling reactions of aromatic aldehydes, 3-hydroxyindole and malononitrile in water at 70 °C was described as the preparation of 2-amino-4,5- dihydro-4-phenylpyrano[3,2-b]indole-3-carbonitrile derivatives. © 2015 Chemical Society of Ethiopia.


Mansoor S.S.,Bioactive Organic Molecule Synthetic Unit | Aswin K.,Bioactive Organic Molecule Synthetic Unit | Logaiya K.,Bioactive Organic Molecule Synthetic Unit | Sudhan P.N.,Bioactive Organic Molecule Synthetic Unit | Malik S.,Bioactive Organic Molecule Synthetic Unit
Research on Chemical Intermediates | Year: 2014

A convenient approach to the synthesis of 2-amino-4,6- diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery. © 2013 Springer Science+Business Media Dordrecht.

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