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Engel P.,University of Barcelona | Boumsell L.,French Institute of Health and Medical Research | Balderas R.,BD Biosciences | Bensussan A.,French Institute of Health and Medical Research | And 10 more authors.
Journal of Immunology | Year: 2015

CD(cluster of differentiation) Ags are cell surfacemolecules expressed on leukocytes and other cells relevant for the immune system. CDnomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies and sanctioned by the World Health Organization. It provides a unified designation system for mAbs, as well as for the cell surface molecules that they recognize. This nomenclature was established by the Human Leukocyte Differentiation Antigens Workshops. In addition to defining the CDnomenclature, these workshops have been instrumental in identifying and determining the expression and function of cell surface molecules. Over the past 30 y, the data generated by the 10 Human Leukocyte Differentiation Antigens Workshops have led to the characterization and formal designation of more than 400 molecules. CD molecules are commonly used as cell markers, allowing the identification and isolation of leukocyte populations, subsets, and differentiation stages. mAbs against these molecules have proven to be essential for biomedical research and diagnosis, as well as in biotechnology. More recently, they have been recognized as invaluable tools for the treatment of several malignancies and autoimmune diseases. In this article, we describe how the CD nomenclature was established, present the official updated list of CD molecules, and provide a rationale for their usefulness in the 21st century. Copyright © 2015 by The American Association of Immunologists, Inc.

Bio-Techne | Date: 2015-09-08

The disclosed methods involve deglycosylating a target molecule to remove target carbohydrates to create vacant glycosylation acceptor sites and then using glycosyltransferases to incorporate replacement carbohydrates into those sites. The methods also involve using glycosytransferases to incorporate new carbohydrates into vacant glycosylation acceptor sites without having to perform in vitro deglycosylation. The replacement or new carbohydrates include a click chemistry moiety that reacts to a click chemistry moiety on a label.

Bio-Techne | Date: 2015-01-19

Dried proteins for scientific, medical research, clinical, life sciences, laboratory, pharmaceutical research use.

Bio-Techne | Date: 2016-02-09

Reagents and chemicals for preclinical, life science and laboratory use.

Bio-Techne and Techne Corporation | Date: 2006-07-25

biological reagents for scientific or medical research use. biological reagents, namely, clinical medical reagents.

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