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Das U.N.,UND Life science | Das U.N.,Jawaharlal Nehru Technological University Kakinada | Das U.N.,Bio Science Research Center
Prostaglandins Leukotrienes and Essential Fatty Acids | Year: 2012

Radiation induces overexpression and activity of the MET oncogene that, in turn, enhances the production of prostaglandin E 2, a pro-inflammatory molecule. Prostaglandin E 2 promotes tumor cell invasion, prevents apoptosis, enhances their metastasis and causes radioresistance. It is proposed that lipoxin A 4, a potent endogenous anti-inflammatory molecule, opposes the actions of prostaglandin E 2 and thus, could promote radiosensitivity, suppress tumor cell proliferation, invasiveness and suppress metastasis. Thus, methods designed to enhance endogenous lipoxin A 4 formation or its synthetic analogs may be useful in the management of cancer. © 2011 Elsevier Ltd. Source


Das U.N.,UND Life science | Das U.N.,Jawaharlal Nehru Technological University Kakinada | Das U.N.,Bio Science Research Center
Clinical Lipidology | Year: 2013

Obesity, insulin resistance, essential hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, osteoporosis, renal failure, Alzheimer's disease, depression, schizophrenia, aging, rheumatological conditions and cancer are low-grade systemic inflammatory conditions in which there is an increase in proinflammatory cytokines and reactive oxygen species, reactive nitrogen species, and proinflammatory eicosanoids, while a decrease in the cellular antioxidants, anti-inflammatory cytokines and certain polyunsaturated fatty acids, and their anti-inflammatory products such as lipoxins (LXs), resolvins (Rvs), protectins, maresins and nitrolipids occurs. This imbalance between the pro- and anti-inflammatory molecules in these diseases suggests that therapeutic strategies directed to suppress inappropriate inflammation may aid recovery from these diseases. It is proposed that both local and systemic delivery of LXs, Rvs, protectins, maresins and nitrolipids, and/or their more stable synthetic analogs, may prove to be useful in these diseases. In this part I of the review, the discussion is centered on the role of LXs, Rvs, protectins and nitrolipids in cancer. © 2013 Future Medicine Ltd. Source


Das U.N.,UND Life science | Das U.N.,Jawaharlal Nehru Technological University Kakinada | Das U.N.,Bio Science Research Center
Clinical Lipidology | Year: 2013

Obesity, insulin resistance, essential hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, osteoporosis, renal failure, Alzheimer's disease, depression, schizophrenia, aging and rheumatological conditions are low-grade systemic inflammatory conditions, in which there is an increase in the production of proinflammatory cytokines, reactive oxygen species, reactive nitrogen species and proinflammatory eicosanoids, while a decrease in the cellular antioxidants, anti-inflammatory cytokines and certain polyunsaturated fatty acids, and their anti-inflammatory products, lipoxins (LXs), resolvins (Rvs), protectins, maresins and nitrolipids, occurs. This imbalance between the pro- and anti-inflammatory molecules in these diseases suggests that therapeutic strategies directed to suppress inappropriate inflammation and enhance the synthesis/action of anti-inflammatory bioactive lipids may aid the prevention of and recovery from these diseases. It is proposed that both local and systemic delivery of LXs, Rvs, protectins, maresins and nitrolipids and/or their more stable synthetic analogs may prove to be useful in these diseases. In this part II of the review, the discussion is centered on the role of LXs, Rvs, protectins and nitrolipids in diabetes mellitus and other diseases. © 2013 Future Medicine Ltd. Source


Das U.N.,Jawaharlal Nehru Technological University Kakinada | Das U.N.,Bio Science Research Center
Nutrition | Year: 2013

Diabetic macular edema and retinopathy are low-grade inflammatory conditions. Infusions of antitumor necrosis factor-α (anti-TNF-α) antibody and antivascular endothelial growth factor (anti-VEGF) antibody have been shown to be at least partly effective in the treatment of diabetic macular edema and proliferative diabetic retinopathy. Intravitreal therapy of diabetic macular edema by the anti-TNF-α antibody has been found to produce significant side effects and anti-VEGF therapy to be ineffective. Nevertheless, these studies have indicated that the suppression of TNF-α and other proinflammatory cytokines and VEGF could be of benefit in diabetic macular edema and retinopathy. The retina is rich in polyunsaturated fatty acids, especially in ω-3, and several studies have shown that polyunsaturated fatty acids prevent diabetic retinopathy. Lipoxins, resolvins, and protectins derived from various polyunsaturated fatty acids possess anti-inflammatory actions and suppress the production of interleukin-6, and TNF-α and VEGF have antiangiogenic actions. In view of these evidences, I propose that lipoxins, resolvins, and protectins could be of significant benefit in the prevention and management of diabetic macular edema and retinopathy. © 2013 Elsevier Inc. Source


Das U.N.,Jawaharlal Nehru Technological University Kakinada | Das U.N.,Bio Science Research Center | Madhavi N.,UND Life science
Lipids in Health and Disease | Year: 2011

Previous studies showed that -linolenic acid (GLA, 18: 3 -6), arachidonic acid (AA, 20:4 -6), eicosapentaenoic acid (EPA, 20: 5 -3) and docosahexaenoic acid (DHA, 22:6 -3) have selective tumoricidal action. In the present study, it was observed that dihomo-gamma-linolenic acid (DGLA) and AA, EPA and DHA have cytotoxic action on both vincristine-sensitive (KB-3-1) and resistant (KB-ChR-8-5) cancer cells in vitro that appeared to be a free-radical dependent process but not due to the formation of prostaglandins, leukotrienes and thromboxanes. Uptake of vincristine and fatty acids was higher while their efflux was lower in KB-3-1 cells compared with KB-ChR-8-5 cells, suggesting that drug resistant cells have an effective efflux pump. GLA, DGLA, AA, EPA and DHA enhanced the uptake and decreased efflux in both drug-sensitive and drug-resistant cells and augmented the susceptibility of tumor cells especially, of drug-resistant cells to the cytotoxic action of vincristine. These results suggest that certain polyunsaturated fatty acids have tumoricidal action and are capable of enhancing the cytotoxic action of anti-cancer drugs specifically, on drug-resistant cells by enhancing drug uptake and reducing its efflux. Thus, polyunsaturated fatty acids either by themselves or in combination with chemotherapeutic drugs have the potential as anti-cancer molecules. © 2011 Das and Madhavi; licensee BioMed Central Ltd. Source

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