New Philadelphia, PA, United States
New Philadelphia, PA, United States

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Patent
Bio Rad Laboratories Inc. | Date: 2016-11-21

A system, including method and apparatus, for generating droplets suitable for droplet-based assays. The disclosed systems may include either one-piece or multi-piece droplet generation components configured to form sample-containing droplets by merging aqueous, sample-containing fluid with a background emulsion fluid such as oil, to form an emulsion of sample-containing droplets suspended in the background fluid. In some cases, the disclosed systems may include channels or other suitable mechanisms configured to transport the sample-containing droplets to an outlet region, so that subsequent assay steps may be performed.


Patent
Bio Rad Laboratories Inc. | Date: 2016-11-14

System, including methods, apparatus, and kits, for forming and concentrating emulsions. An exemplary system may comprise a device including a sample well configured to receive sample-containing fluid, a continuous-phase well configured to receive continuous-phase fluid, a droplet well, and a channel network interconnecting the wells. The system also may comprise an instrument configured to operatively receive the device and to create (i) a first pressure differential to produce an emulsion collected in the droplet well and (ii) a second pressure differential to decrease a volume fraction of continuous-phase fluid in the emulsion, after the emulsion has been collected in the droplet well, by selectively driving continuous-phase fluid, relative to sample-containing droplets, from the droplet well.


Patent
Bio Rad Laboratories Inc. | Date: 2016-11-14

System, including methods, apparatus, and kits, for forming emulsions. An exemplary system may comprise a device including a sample well configured to receive sample-containing fluid, a continuous-phase well configured to receive continuous-phase fluid, and a droplet well. The device also may include a channel network having a first channel, a second channel, and a third channel that meet one another in a droplet-generation region. The system also may comprise a holder for the device. The system further may comprise an instrument configured to operatively receive an assembly including the device and the holder and to drive sample-containing fluid from the sample well to the droplet-generation region via the first channel, continuous-phase fluid from the continuous-phase well to the droplet-generation region via the second channel, and sample-containing droplets from the droplet-generation region to the droplet well via the third channel.


Patent
Bio Rad Laboratories Inc. | Date: 2016-11-29

Modified Protein A, Protein G, Protein L, or Protein A/G that lacks antibody binding activity, and methods of the modified proteins use for purifying antibodies is provided.


Patent
Bio Rad Laboratories Inc. | Date: 2016-08-11

Disclosed is a system and method for characterizing optical filters in a flow cytometer and optionally checking the operation of detectors in the flow cytometer. In some embodiments, the system may utilize an LED board having an opening through which the fluorescence and side scatter beams, rays, or images pass and light emitting diodes around the opening that emit light having different spectral profiles. The different spectral profiles allow the system to identify the optical filters that are placed in the flow cytometer, to verify detector operation, to assist in instrumentation troubleshooting, and to provide a quantitative reference for detector comparison.


Patent
Bio Rad Laboratories Inc. | Date: 2016-09-21

Polyacrylamide gels that offer high resolution in protein separations and are more stable relative to hydrolysis than conventional polyacrylamide gels that rely on Tris or Tris-Bis as buffering agents are made by incorporating triethanolamine in place of most or all of the Tris or Tris-Bis.


Patent
Bio Rad Laboratories Inc. | Date: 2016-10-18

Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.


Patent
Bio Rad Laboratories Inc. | Date: 2016-08-19

A method and apparatus for pumping fluid through tubing are provided. The method includes orbiting first rollers around the periphery of a first disk at a first tangential speed in a first angular sector and a slower, second tangential speed in a second angular sector, orbiting second rollers around the periphery of a second disk at the second tangential speed, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one first roller to fully compress the tubing at the first tangential speed and simultaneously causing the one second roller to fully compress the tubing at the second tangential speed. The apparatus includes a first disk with a recess in its periphery, the first angular sector with a nominal first radius, and a second angular sector with a nominal second radius; and a second disk with the nominal first radius and a recess in its periphery.


Patent
Bio Rad Laboratories Inc. | Date: 2017-02-22

System, including methods, apparatus, and kits, for forming emulsions. The system may include an instrument and a microfluidic chip received by the instrument. The instrument may apply pressure to prospective emulsion phases held by the chip, to drive formation and collection of emulsions in the chip. In some embodiments, the instrument may stop applying pressure to the chip when a change in pressure meeting a predefined condition is detected by the instrument. The change may indicate that an endpoint of droplet generation has been reached.


Patent
Bio Rad Laboratories Inc. | Date: 2017-01-18

A file with a unique filename is transferred from a client computer to a server computer in chunks, which can be packaged into packets including metadata. The server computer can record indices of received chunks in a local metadata file associated with the file. Upon receiving the filename in a subsequent client request after a connection loss, the server computer can use the associated metadata file to determine whether portions of the file are missing. If so, the server computer can send indices corresponding to missing ranges instead of the client computer resending the whole file.

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