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Elstree, United Kingdom

Dash C.,CD Consultants | Gascoigne E.,Bio Products Laboratory BPL Ltd | Gillanders K.,Bio Products Laboratory BPL Ltd | Gooi H.,Kings College
PLoS ONE | Year: 2015

Background and Objectives A multi-centre, non-comparative study examining the efficacy and safety of Subgam, a normal immunoglobulin (IgG) given weekly as a rapid subcutaneous infusion to patients with primary immune deficiency (PID), is reported. Also included is a summary of adverse drug reactions associated with the use of marketed Subgam in the UK. Materials and Methods 50 patients with stable PID on IgG therapy were enrolled: Stage 1 included three infusions with prior IgG product followed by 6 months with Subgam, Stage 2 involved long-term Subgam therapy up to 4 years. Results Stage 1, 85% of the subjects aged >12 years and 93% of the subjects aged <12 years achieved IgG levels ≥ 6 and ≥ 4 g/L, respectively at all observations. There were 3.62 infections/ patient/year during Subgam treatment. The most common product-related events were infusion site reactions (50% of patients). Recent post-hoc pharmacokinetics analysis of the post-infusion serum total IgG concentration indicated that the mean dose-normalised incremental IgG AUCτ following intravenous dosing (120.5 g.day/L) was 1.64-fold that of the dose-normalised mean incremental IgG AUCτ following subcutaneous dosing (73.6 g. day/L), corresponding to an estimated IgG bioavailability for subcutaneous dosing of 61%. Only 34 post-licensing adverse reactions have been received in 30 patients over a period of 10 years; fourteen were classed as serious as defined by the ICH guidelines on good clinical practice. The most common post-licensing adverse reaction was infusion site reaction (7 reports). There were 7 reports of flu-like symptoms (pyrexia/shivering/rigors/feeling hot or cold), 2 other reports of combined flu-like symptoms and infusion site reactions, 5 reports of generalised skin reactions, and 3 reports of combined infusion site and skin reactions. There were also reports of anaphylaxis (2 reports) and 8 other adverse events (including headache). In conclusion, Subgam is effective and well tolerated in the treatment of PID. © 2015 Dash et al. Source

Matysiak M.,Medical University of Warsaw | Bobrowska H.,Specialist Center for Medical Care of Mother and Children | Balwierz W.,Jagiellonian University | Chybicka A.,Wroclaw Medical University | And 4 more authors.
Haemophilia | Year: 2011

Optivate ® is a high-purity FVIII/VWF product. Its safety, tolerability and efficacy in subjects ≥12years have been demonstrated. This study was undertaken to assess Optivate ® in children with haemophilia A. Twenty-five children, including one PUP (previously untreated patient), aged 1-6years (mean 4.67years) were treated with Optivate ® for 26weeks. Inhibitors were assessed every 3months and viral status at the study start and end. Prophylaxis was used by five boys and on demand by twenty. The mean number of bleeds in the study was lower compared to the same period pre-study (12.0/child vs. 16.2/child), with fewer bleeds (P<0.05) in the prophylactic subgroup (8.0/child) compared with the on-demand sub-group (13.4/child). Fourteen major bleeds were reported, all by the on-demand sub-group. Children on prophylaxis were administered a mean of 59.4 infusions; on-demand group 35.1 infusions. A total of 998 infusions were used with a mean dose of 29.1IUkg -1, and a mean of 38.6 exposure days (ED). Children <4years used higher doses, and reported fewer bleeds than older children. Children's Parents/Guardians rated Optivate ® as helpful or very helpful in controlling 97.5% of bleeds by the prophylactic group, and in 98.5% of the bleeds in the on-demand group. Only 5 of 101 ADRs were treatment-related events (5%), all were mild and non-serious. There were no clinically significant changes in vital signs, viral transmissions or inhibitors. In young children Optivate ® was well tolerated, safe and efficacious. © 2011 Blackwell Publishing Ltd. Source

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