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Santiniketan, India

Laskar R.A.,Bio Organic Chemistry Laboratory | Begum N.A.,Bio Organic Chemistry Laboratory | Mir M.H.,Aliah University | Rohman M.R.,North - Eastern Hill University | Khan A.T.,Indian Institute of Technology Guwahati
Tetrahedron Letters | Year: 2013

Various aromatic aldehydes on reaction with 2-mercaptoethanol provided an unanticipated product, bis(2-hydroxyethyl)dithioacetals (3) as the major product along with the expected product 1,3-oxathiolanes (4) in the presence of 0.05 equiv amount of nickel(II) chloride hexahydrate (NiCl2·6H 2O) under solvent-free conditions. Products 3c and 3e exhibit an interesting hydrogen-bonded infinite supra-molecular helical structure. © 2013 Elsevier Ltd. All rights reserved.

Begum N.A.,Bio Organic Chemistry Laboratory | Roy N.,Bio Organic Chemistry Laboratory | Laskar R.A.,Bio Organic Chemistry Laboratory | Roy K.,Jadavpur University
Medicinal Chemistry Research | Year: 2011

A series of chalcone analogues and some of their derivatives were synthesized and subjected to the mosquito larvicidal study. Chalcones having electron releasing group(s) on either ring A or ring B showed high toxicity. Electron withdrawing group(s), especially at ring B, reduced the activity of chalcones. The activity was abruptly decreased due to replacement of ring A by CH3, extension of conjugation or blocking of α,β- unsaturated ketone part of chalcones by derivatization. Quantitative structure-activity relationship (QSAR) studies of these compounds were performed using various spatial, electronic and physicochemical parameters. Genetic Function approximation with linear and spline options was used as the chemometric tool for developing the QSAR models. © 2010 Springer Science+Business Media, LLC.

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