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Ives A.,University of Lausanne | Nomura J.,University of Lausanne | Nomura J.,Bio-Medical Research Limited | Martinon F.,University of Lausanne | And 6 more authors.
Nature Communications | Year: 2015

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires intracellular generation of reactive oxygen species (ROS). We present evidence that macrophage secretion of IL1β upon stimulation with ATP, crystals or LPS is mediated by a rapid increase in the activity of xanthine oxidase (XO), the oxidized form of xanthine dehydrogenase, resulting in the formation of uric acid as well as ROS. We show that XO-derived ROS, but not uric acid, is the trigger for IL1β release and that XO blockade results in impaired IL1β and caspase1 secretion. XO is localized to both cytoplasmic and mitochondrial compartments and acts upstream to the PI3K-AKT signalling pathway that results in mitochondrial ROS generation. This pathway represents a mechanism for regulating NLRP3 inflammasome activation that may have therapeutic implications in inflammatory diseases. © 2015 Macmillan Publishers Limited. All rights reserved. Source


Trademark
Bio-Medical Research Limited | Date: 2015-12-15

Medical apparatus, instruments, equipments and devices for the treatment, control or prevention of pelvic floor weakness and incontinence in humans, apparatus for use in control of pelvic floor weakness and incontinence; incontinence devices; pelvic floor rehabilitation devices; female incontinence devices; male incontinence devices.


Trademark
Bio-Medical Research Limited | Date: 2015-12-15

Medical apparatus, instruments, equipments and devices for the treatment, control or prevention of incontinence in humans, including the treatment, control or prevention of pelvic floor weakness; apparatus for use in control of pelvic floor weakness and incontinence; incontinence devices; pelvic floor rehabilitation devices for the treatment, control or prevention of incontinence; female incontinence devices; male incontinence device.


Patent
Bio-Medical Research Limited and University College Dublin | Date: 2010-01-08

A method of and apparatus for stimulating pelvic floor muscles in a patient comprises applying at least one electrode externally to each side of the patients body in the region of the pelvis, and energising the electrodes to apply a muscular stimulation current which flows laterally across the patient through the patients pelvic floor. Preferably a plurality of electrodes are applied symmetrically on each side of the body. The electrodes may be incorporated in a garment.


Patent
Bio-Medical Research Limited | Date: 2010-06-16

A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A

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