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Düsseldorf, Germany

Ebada S.S.,BIO MAR | Ebada S.S.,Ain Shams University | Fischer T.,BIO MAR | Hamacher A.,Heinrich Heine University Dusseldorf | And 5 more authors.
Natural Product Research | Year: 2014

Chemical investigation of the mycelial extract of a mixed culture of two marine alga-derived fungal strains of the genus Aspergillus has yielded one new cyclotripeptide, psychrophilin E (1), the recently reported oxepin-containing alkaloids, protuboxepin A (2) and oxepinamide E (3), together with three other polyketide derivatives (4-6). The chemical structure and relative and absolute configurations of psychrophilin E (1) were unambiguously established based on HRMS, 1D, 2D NMR and chiral-phase HPLC analysis of its hydrolysate. All the isolated compounds were assessed for their anti-proliferative activity against four different human cancer cell lines and some of them revealed selective activities. © 2014 © 2014 Taylor & Francis. Source


Ebada S.S.,BIO MAR | Ebada S.S.,Ain Shams University | Fischer T.,BIO MAR | Klassen S.,BIO MAR | And 4 more authors.
Natural Product Research | Year: 2014

Bioactivity-guided chemical investigation of a co-culture of marine-derived micro-organisms has yielded one new steroid, 7β-hydroxycholesterol-1β-carboxylic acid (1) with an unprecedented carboxylic acid group at C-1, together with three known steroidal metabolites (2-4). The chemical structures and stereochemistry of the isolated compounds were unambiguously determined based on extensive 1D, 2D NMR and HR-ESI-MS measurements. The isolated compounds were assessed for their cytotoxic activity against four different human tumour cell lines K562 (leukaemia), HCT116 (colon), A2780 (ovary) and its cisplatin-resistant mutant (A2780 CisR), and they revealed moderate activities with IC50 values ranging from 10.0 to 100.0 M. © 2014 Taylor & Francis. Source

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