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A specific probiotic formulation composed of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+) has been marketed in North America since 1996. The strains and the commercial products have been evaluated for safety, identity, gastrointestinal survival, and stability throughout shelf life. The capacity of both the fermented beverages and the capsules to reduce incidences of antibiotic-associated diarrhea and Clostridium difficile infection (CDI) has been demonstrated in human clinical trials. Individual strains and the finished products have shown antimicrobial activity against C. difficile and toxin A/B neutralization capacity in vitro. The use of this specific probiotic formulation as part of a bundle of preventive measures to control CDI in healthcare settings is discussed. © 2015 The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.


The present invention relates to methicillin-resistant Staphylococcus aureus growth inhibition by lactic acid bacterium strains. More specifically it is directed to the use of lactic acid bacterium strains, compositions comprising lactic acid bacterium strains, methods of use and kits thereof to inhibit the growth of methicillin-resistant Staphylococcus aureus. This invention more specifically relates to the inhibitory effect of lactic acid bacterium strains Lactobacillus acidophilus and Lactobacillus caseion methicillin-resistant Staphylococcus aureus.


The present invention concerns a purified strain Lactobacillus acidophilus identified as CNCM/I-1492 (hereinafter called L.a. I-1492), the microorganism from this strain, a lactic ferment comprising this strain, a process for making dairy products using this ferment, the dairy products obtained by this process and containing at least 500 million per gram et Lactobacillus acidophilus (including the L.a. 1-1492 strain) and where at least 380 million/gram are L.a. I-1492, and the use of the L.a. I-1492 strain as a drug, in particular for reducing the level of cholesterol in the blood of a mammal or for treating infectious diseases comprising colds, sinusitis and urinary infections.


Patent
Bio K Plus International Inc. | Date: 2011-11-29

The present invention broadly relates to the use of probiotics for the treatment and prevention of dermatitis. More particularly, the present invention relates to the use of a composition comprising Lactobacillus acidophilus strain I-1492 deposited at the CNCM, a Lactobacillus casei LBC80R strain and a carrier for treating or preventing hand dermatitis.


Patent
Bio K Plus International Inc. | Date: 2011-05-17

The present invention concerns a lactic composition useful for the prevention or treatment of diarrhea such as antibiotic associated diarrhea or tourista. The composition according to the invention contains at least a bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus acidophilus I-1492, Lactobacillus casei and a mixture of thereof.


Trademark
Bio K Plus International Inc. | Date: 2016-02-10

Probiotic compositions for use as ingredients for food and beverages, namely, probiotic bacteria and probiotic bacterial cultures; Bacterial preparations other than for medical and veterinary use, namely, probiotic bacteria and probiotic bacterial cultures; Bacterial preparations other than for medical use, namely, bacteria preparations made up of various accepted strains for human consumption; Fermentation extract, namely, microbiological fermentation extracts using milk, soya or rice as a carrier; Bacterial preparations other than for medical and veterinary use, namely, bacterial and bacteorological preparations made up of various accepted strains for human consumption. Bacterial and bacteriological preparations for medical or veterinary purposes, namely, probiotic bacteria and probiotic bacterial cultures; Bacterial and bacteriological preparations for medical purposes, namely, bacteria preparations made up of various accepted strains for human consumption; Dietary and nutritional supplements, namely, synbiotic, prebiotic and probiotic strains using milk, soya and rice as carriers; dietary and nutritional supplements, namely, tablets, capsules and beverages made of various accepted probiotic strains using milk, soya and rice as carriers; Ferments for pharmaceutical purposes, namely, microbiological fermentation extracts using milk, soya or rice as a carrier; Bacterial and bacteriological preparations made up of various accepted strains for human consumption for medical or veterinary purposes.


Trademark
Bio K Plus International Inc. | Date: 2015-07-16

Probiotic products namely, capsules, chewable tablets and preparations made up of bacteria for promoting health and wellness; Preparations made up of ferments namely, probiotic bacteria for the prevention and treatment of the digestive system and diseases related thereto; Preparations containing probiotic bacteria for the prevention and treatment of the digestive system and diseases related thereto; Natural health products namely, microbiological fermentation extracts made of probiotic bacteria for the prevention and treatment of the digestive system and diseases related thereto; Symbiotic and prebiotic products, namely, preparations made up of bacteria for promoting health and wellness; Probiotic drinks made of a blend of probiotic strains using milk, soya and rice as carriers and probiotic energy drinks; fruit compote made with a blend of probiotic strains; Operation of a website related to probiotics, food and nutrition; operation of a social media website related to probiotics, food and nutrition; Publication of promotional material related to the field of probiotics, food and nutrition; Organisation of ceremonies, shows, conferences and seminars in the field of food and nutrition, health and cooking; Organisation of promotional campaigns related to health, food and nutrition.


Trademark
Bio K Plus International Inc. | Date: 2015-07-16

Natural health products, namely, microbiological fermentation extracts using carriers containing milk, soya or rice, as well as concentrates using carriers containing milk, soya or rice solids; Probiotic products, namely, capsules and preparations made up of bacteria for promoting health and wellness in the nature of bacteria for use in food manufacture, probiotic bacteria and probiotic bacterial cultures. Non-alcoholic beverages, namely, malted milk based beverages for medical purposes; Symbiotic, prebiotic and probiotic functional foods and nutritional supplements, namely, tablets, capsules and beverages made of a blend of probiotic strains using carriers containing soya or rice solids in the nature of probiotic supplements; Probiotic products, namely, capsules and preparations made up of bacteria for promoting health and wellness in the nature of probiotic supplements; Preparations made up of ferments, namely, probiotic bacteria preparations for the prevention and treatment of constipation, bloating, diarrhea, and similar digestive system conditions; Preparations containing probiotic bacteria for the prevention and treatment of the digestive system; Natural health products, namely microbiological fermentation extracts made of probiotic bacteria for the prevention and treatment of constipation, bloating, diarrhea, and similar digestive system conditions; Formulas, namely, lactic ferments and soya ferments for pharmaceutical purposes and capsules made up of bacteria for medical purposes; Chewable tablets and compotes for promoting health and wellness and for the prevention and treatment of constipation, bloating, diarrhea, and similar digestive system conditions.


Trademark
Bio K Plus International Inc. | Date: 2015-11-19

Non-medicated skin care preparations, namely, body gels, body creams, body lotions, body cleansers, body moisturizers, and cosmetic preparations for skin symptoms and conditions related thereto, namely, dry skin. Probiotic products, namely, nutritional supplements in the nature of probiotic compositions in capsule form made up of bacteria for promoting health and wellness; ferments for pharmaceutical purposes in the nature of bacteria strains for managing, preventing and treating skin diseases; natural health products in the nature of nutritional supplements made from the microbiological fermentation of a blend of bacteria strains using milk, rice or soya as a carrier; dietary and nutritional supplements, namely, symbiotic, prebiotic and probiotic products made of a blend of bacteria strains using milk, rice or soya as a carrier for the prevention and treatment of skin disorders. Probiotic beverages, namely, probiotic yogurt drinks, probiotic milk, probiotic beverages having a milk base, probiotic whey drinks, probiotic soy milk drinks, probiotic rice milk drinks made through the microbiological fermentation of a blend of bacteria strains using milk, rice or soya as a carrier. Organization of ceremonies, shows, conferences and seminars in the fields of health and wellness, probiotics, skin diseases and conditions related thereto, skin care, food and nutrition for commercial, promotional and advertising purposes; promotional services, namely, organization of promotional campaigns for business in the nature of trade shows and marketing campaigns for others in the fields of health and wellness, probiotics, skin diseases and related conditions, skin care, and food and nutrition. Publication of printed matter, namely, promotional material in the fields of probiotics, skin diseases and related conditions, diet and nutrition. Providing a website featuring information in the fields of health and wellness, including information related to probiotics, skin disease symptoms and related conditions, diet and nutrition.


A lactic composition containing at least a bacterial strain selected from the group consisting of Lactobacillus acidophilus, Lactobacillus casei and a mixture of Lactobacillus acidophilus and Lactobacillus casei, and a whole broth of the bacterial strain or the mixture of the bacterial strains, is useful for the prevention or treatment of disorders which are angiogenesis dependant. Both the lactic composition and its supernatant can be used for prevention or treatment of angiogenesis dependant disorders. The supernatant of the lactic composition exhibits antiangiogenic properties.

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