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Kim S.S.,Jeju National University | Hyun C.-G.,Bio industry Development Center | Lee N.H.,Jeju National University
Natural Product Communications | Year: 2011

This study examined the chemical composition of Neolitsea aciculata essential oil (NAE) and its biological activities. NAE was obtained by hydro-distillation of N. aciculata leaves collected in Jeju Island and analyzed by gas chromatography equipped with a mass spectrometer detector. 1-Dodecen-3-yne (12.5%), calarene (11.5%) and elemol (9.5%) were identified as the major components of NAE. The antibacterial and anti-inflammatory activities of NAE against skin pathogens were examined to determine the protective properties against acne vulgaris. NAE exhibited moderate to strong antibacterial activity against drug-susceptible and -resistant Propionibacterium acnes and Staphylococcus epidermidis, which are known as acne-causing bacteria. In addition, NAE reduced the P. acnes-induced secretion of tumor necrosis factor-α(TNF-α) and interleukin-8 (IL-8) in THP-1 cells, highlighting its anti-inflammatory effects. The DPPH radical scavenging activities of NAE also revealed moderate antioxidant properties (IC 50, 21.3 μL/mL). Overall, NAE is an attractive candidate as an ingredient in skin care products.


Shin T.,Jeju National University | Ahn M.,Jeju National University | Kim G.O.,Bio industry Development Center | Park S.U.,Chungnam National University
Oriental Pharmacy and Experimental Medicine | Year: 2015

The radish (Raphanus sativus L.; Cruciferae) is cultivated and used as a food worldwide, and has many useful biological properties. Increasingly, it is apparent that the radish may potentially be used to treat various diseases. The radish contains alkaloids and nitrogen compounds, coumarins, enzymes, gibberellins, glucosinolates, organic acids, phenolic compounds, pigments, polysaccharides, proteoglycans, and sulfur compounds; these exhibit antimicrobial, antioxidative, antitumor, and antiviral activities, and act as calmodulin antagonists, growth inhibitors, anti-hypotensive agents, and inhibitors of platelet aggregation. Some components have immunological properties. The radish contains phytoalexins and a “pungent principle”. Certain components exhibit serological activity, stimulate intestinal motility, and prevent cardiovascular disease. The biological effects of the radish are inexorably linked to materials therein that exert antioxidant and anti-inflammatory effects. This review summarizes the biological effects of radish components. © 2015, Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media Dordrecht.


Ahn M.,Jeju National University | Koh R.K.,Bio industry Development Center | Kim G.O.,Bio industry Development Center | Shin T.,Jeju National University
Oriental Pharmacy and Experimental Medicine | Year: 2013

The aim of this study was to evaluate whether the crude aqueous extract of purple Bordeaux radish (Raphanus sativus L.) (PBR) ameliorates ethanol-induced gastric injury in rats. Animals were divided into the following nine groups: normal, distilled water-treated vehicle control, groups orally administered PBR extract (250, 500 and 1,000 mg/kg, daily for 2 weeks), with or without ethanol treatment (5 ml/kg) 24 h after final administration of PBR extract, and a group treated with ethanol alone. Rats treated with PBR extract (250-1,000 mg/kg) for 2 weeks showed no significant effects on body weight and gastric mucosa. Pretreatment with PBR extract at doses of 500 and 1,000 mg/kg, but not 250 mg/kg, significantly ameliorated ethanol-induced gastric hemorrhages in rats (p < 0.05). The immunoreactivities of inducible nitric oxide (iNOS) and its byproduct nitrotyrosine in the gastric mucosa of ethanol-treated rats pretreated with 500 mg/kg PBR extract were significantly reduced, as compared with rats treated with ethanol alone (p < 0.05). Collectively, these findings suggest that pretreatment with PBR extract ameliorates ethanol-induced damage in the gastric mucosa, which is mediated partly by the anti-oxidative activity of the extract. The precise mechanism of this gastroprotective action of PBR extract should be investigated further. © 2013 Institute of Korean Medicine, Kyung Hee University.

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