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Chen H.,Binzhou City Center Hospital | Liu X.,Binzhou City Center Hospital | Xu L.,Jining No. 1 Peoples Hospital
Experimental and Therapeutic Medicine | Year: 2016

The aim of the study was to examine the relationship between incisal condition after loop electrosurgical excision procedure (LEEP) operation for cervical intraepithelial neoplasia (CIN) patients and prognosis. A study of high-risk incisal margin positive cases was also performed. We compared the differences in the prognosis of the 1-year follow-up visit in the 120 CIN patients admitted to the hospital during the period from April 2013 to April 2014. A total of 43 cases of positive incisal margin (35.8%), and 77 negative cases were included in the study. The differences in age, course of disease, and CIN level between the two groups showed no statistical significance (P>0.05). In the positive group, the positive ratio was significantly higher than that of the negative group (P<0.05). The positive incisal margin showed a significant positive correlation with human papillomavirus (HPV) positivity (r=0.327, P=0.035). The condition of most patients with positive incisal margin and HPV was critical, which was followed by positive incisal margin and negative HPV. The patients with the best prognosis were those with significant negative incisal margin as well as HPV (P<0.05). In conclusion, the positive incisal margin after LEEP operation was associated with relapse of the disease. Thus, considering the HPV test into consideration is valuable for the prognosis of the disease. © 2016, Spandidos Publications. All rights reserved. Source


Guo J.,Tsinghua University | Sun Y.,Binzhou City Center Hospital | Sun Y.,Fujian Medical University | Xue L.-J.,Shenzhen Baoan District Songgang Peoples Hospital | And 5 more authors.
Sleep and Breathing | Year: 2016

Purpose: Continuous positive airway pressure (CPAP) therapy may decrease the risk of mortality and cardiovascular events in patients with obstructive sleep apnea. However, these benefits are not completely clear. Methods: We undertook a meta-analysis of randomized clinical trials identified in systematic searches of MEDLINE, EMBASE, and the Cochrane Database. Results: Eighteen studies (4146 patients) were included. Overall, CPAP therapy did not significantly decrease the risk of cardiovascular events compared with the control group (odds ratio (OR), 0.84; 95 % confidence intervals (CI), 0.62–1.13; p = 0.25; I2 = 0 %). CPAP was associated with a nonsignificant trend of lower rate of death and stroke (for death: OR, 0.85; 95 % CI, 0.35–2.06; p = 0.72; I2 = 0.0 %; for stroke: OR, 0.56; 95 % CI, 0.18–1.73; p = 0.32; I2 = 12.0 %), a significantly lower Epworth sleepiness score (ESS) (mean difference (MD), −1.78; 95 % CI, −2.31 to −1.24; p < 0.00001; I2 = 76 %), and a significantly lower 24 h systolic and diastolic blood pressure (BP) (for 24 h systolic BP: MD, −2.03 mmHg; 95 % CI, −3.64 to −0.42; p = 0.01; I2 = 0 %; for diastolic BP: MD, −1.79 mmHg; 95 % CI, −2.89 to −0.68; p = 0.001; I2 = 0 %). Daytime systolic BP and body mass index were comparable between the CPAP and control groups. Subgroup analysis did not show any significant difference between short- and mediate-to-long-term follow-up groups with regard to cardiovascular events, death, and stroke. Conclusions: CPAP therapy was associated with a trend of decreased risk of cardiovascular events. Furthermore, ESS and BP were significantly lower in the CPAP group. Larger randomized studies are needed to confirm these findings. © 2016 Springer-Verlag Berlin Heidelberg Source


Sun Y.,Fujian Medical University | Sun Y.,Binzhou City Center Hospital | Huang Z.-Y.,Fujian Medical University | Wang Z.-H.,Fujian Medical University | And 5 more authors.
Molecular and Cellular Biochemistry | Year: 2015

To investigate the involvement of transforming growth factor-β1 (TGF-β1) and tissue inhibitor of metalloproteinase 4 (TIMP-4) in influencing the severity of atrial fibrosis in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). The degree of myocardial fibrosis was evaluated using Masson staining. The expression levels of TGF-β1, TIMP-4, matrix metalloproteinase-2 (MMP-2), type I collagen, and type III collagen were estimated by Western blot analysis. Additionally, TGF-β1 and TIMP-4 mRNA levels were quantified by qRT-PCR. The effect of TGF-β1 stimulation on TIMP-4 expression was assessed by in vitro stimulation of freshly isolated human atrial fibroblasts with recombinant human TGF-β1, followed by Western blot analysis to detect changes in TIMP-4 levels. Masson stain revealed that the left atrial diameter and collagen volume fraction were obviously increased in AF patients, compared to sinus rhythm (SR) controls (both P < 0.05). Western blot analysis showed significantly elevated levels of the AF markers MMP-2, type I collagen, and type III collagen in the AF group, in comparison to the SR controls (all P < 0.05). In the AF group, TGF-β1 expression was relatively higher, while TIMP-4 expression was apparently lower than the SR group (all P < 0.05). TIMP-4 expression level showed a negative association with TGF-β1 expression level (r = −0.98, P < 0.01) and TGF-β1 stimulation of atrial fibroblasts led to a sharp decrease in TIMP-4 protein level. Increased TGF-β1 expression and decreased TIMP-4 expression correlated with atrial fibrosis and ECM changes in the atria of RHD patients with AF. Notably, TGF-β1 suppressed TIMP-4 expression, suggesting that selective TGF-β1 inhibitors may be useful therapeutic agents. © 2015, Springer Science+Business Media New York. Source


Sun Y.,Fujian Medical University | Huang Z.-Y.,Fujian Medical University | Sun Q.-R.,Binzhou City Center Hospital | Qiu L.-P.,Binzhou City Center Hospital | And 2 more authors.
Acta Cardiologica | Year: 2016

Objective Studies suggest that continuous positive airway pressure (CPAP) therapy may decrease blood pressure for patients with obstructive sleep apnoea (OSA). However, these benefits are not completely clear. Method We undertook a meta-analysis of randomized trials identified in systematic researches of MEDLINE, EMBASE, and the Cochrane Database. Results Twelve studies (1,720 patients) were included. Overall, CPAP therapy significantly decreased 24-h systolic blood pressure (SBP) (MD, -2.03; 95% CI, -3.64 to -0.42; P = 0.01; I2 = 0%) and 24-h diastolic blood pressure (DBP) (MD, -1.79; 95% CI, -2.89 to -0.68; P = 0.001; I2 = 0%) compared with the control group. Meanwhile, CPAP was associated with significantly lower daytime DBP (MD, -1.43; 95% CI, -2.67 to -0.19; P = 0.02; I2 = 0%), nighttime SBP (MD, -3.94; 95% CI, -5.85 to -2.04; P < 0.0001; I2 = 34%), nighttime DBP (MD, -1.64; 95% CI, -2.88 to -0.40; P = 0.009; I2 = 0%), clinic SBP (MD, -4.53; 95% CI, -6.07 to -2.99; P < 0.00001; I2 = 70%) and clinic DBP (MD, -2.94; 95% CI, -4.16 to -1.72; P < 0.00001; I2 = 56%). Furthermore, the risk of cardiovascular events was significantly decreased in the CPAP group (OR, 0.59; 95% CI, 0.36 to 0.98; P = 0.04; I2 = 0%). Conclusions CPAP therapy was associated with a significantly decreased level of BP and cardiovascular events. However, larger randomized studies are needed to confirm these findings. © 2016, Acta Cardiologica. All rights reserved. Source

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