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Wang D.,Shandong Academy of Sciences | Shi J.,Affiliated to Binzhou Medical College | Liang S.,Binzhou Medical University | Lu S.,Shandong Academy of Sciences | And 6 more authors.
Clinical and Translational Oncology | Year: 2013

Objective To assess the predictability of dose-volume histogram (DVH) parameters for radiation pneumonitis (RP) using receiver operating characteristic (ROC) curve. Methods One hundred and thirty-five cases of locally advanced non-small cell lung cancer patients treated with three-dimensional radiotherapy and chemotherapy were analyzed retrospectively. The end point of follow-up was C2 grade RP defined according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0. The ROC curve was used to explore the predictive sensitivity (SEN), specificity (SPE), positive predictive value (PPV), and negative predictive value (NPV) for potential DVH parameters associated with RP. Results Relative volumes of total lungs receiving ≥5 Gy (V5), ≥10 Gy (V10), ≥13 Gy (V 13), ≥20 Gy (V20), and mean lung dose (MLD), were all correlated to the development of RP (p < 0.05), among which V5 and V20 were the most important factors (p = 0.045 and 0.037; OR = 3.166 and 3.030). However, collinearity was found between V5 and V 20 (Spearman's rho 0.771, p < 0.01). The area under the ROC curve was 0.643 and 0.648 for using V5 and V20 as predictors. If predictive cut-off values were established as follows: V5 = 0.8 and V20 = 0.3, the parameters could provide predictive SEN, SPE, PPV and NPV were 0.387 and 0.581, 0.882 and 0.701, 0.444 and 0.321, and 0.855 and 0.873, respectively. Conclusions V5 and V20 could act as predictors for RP; however, single DVH metrics did not appear to have high predictive power for RP. © Federación de Sociedades Españolas de Oncología (FESEO) 2012. Source

Wen L.,Central Hospital of Binzhou | Zhang Y.-Y.,Hubin Eye Hospital | Liu D.-S.,Central Hospital of Binzhou | Qi Y.-Q.,Hubin Eye Hospital
International Journal of Ophthalmology | Year: 2011

AIM: To explore the timing, method and the clinical efficacy for traumatic cataract. METHODS: Fifty cases of traumatic cataract were reviewed to analyse the clinical values of different methods of surgery selected according to the situation of traumatic cataract. RESULTS: Six or 12 months after operation, postoperative vision was increased in all patients. The best corrected vision was 0.05-0.25 in 12 eyes (24%), 0.3-0.5 in 22 eyes (44%), > 0.5 in 16 eyes (32%). CONCLUSION: If the operator chooses the appropriate timing and method according to the situation of the eyes, better curative effect can be obtained in surgical treatment of the traumatic cataract. Source

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