Cambridge, MA, United States
Cambridge, MA, United States

Time filter

Source Type

Patent
Bind Biosciences Inc. | Date: 2014-09-29

This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).


Patent
Bind Biosciences Inc. | Date: 2012-12-17

This application provides a high throughput method of making nanoparticles that utilizes plates comprising wells (e.g., 96-well plates).


Patent
Bind Biosciences Inc. | Date: 2010-02-18

This application provides methods of making modified cells containing pre-functionalized poly(ethylene glycol) (PEG) and/or other pre-functionalized polymers are provided. The modified cells produced according to the disclosed methods as well as their use in the treatment of various diseases are also provided.


Patent
Bind Biosciences Inc. | Date: 2012-04-04

The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.


Patent
Bind Biosciences Inc. | Date: 2012-10-30

The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.


Patent
Bind Biosciences Inc. | Date: 2012-10-24

The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.


This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This polymerization from approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a coupling to that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses orthogonal chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.


Patent
Bind Biosciences Inc. | Date: 2012-12-13

The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.


Trademark
BIND Biosciences Inc. | Date: 2013-03-22

Pharmaceutical preparations for the treatment of cancer. Research and development of pharmaceutical products for others.


Trademark
BIND Biosciences Inc. | Date: 2013-03-29

Pharmaceutical preparation for the treatment of cancer. Research and development of pharmaceutical products for others.

Loading BIND Biosciences Inc. collaborators
Loading BIND Biosciences Inc. collaborators