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Sun Y.,The Affiliated Hospital to Bin Zhou Medical University | Wang P.,Bin Zhou Medical University | Li Y.,Bin Zhou Medical University | Jiao F.,Bin Zhou Medical University | And 4 more authors.
Genetics and Molecular Biology | Year: 2010

Methemoglobin (Hb-M) is a rare hemoglobinopathy in China. We hereby report on a family living in Yantai, East China, with congenital cyanosis due to Hb-M mutation. The proband, a 65-year-old female, presented 63% oxygen saturation. Both Hb-M concentration and arterial oxygen saturation remained unchanged, even following intravenous treatment with methylene blue. There was also no change in blood-color (chocolate-brown) after adding 0.1% KCN. A fast-moving band (Hb-X) in hemolysates was found by cellulose acetate electrophoresis, the Hb-X/Hb-A ratio exceeding 10%. GT transition at 131nt of exon 2, although present in one of the α2-globin alleles, was not found in α1-globin alleles as a whole. This mutation leads to the aspartic acid to tyrosine substitution (Asp76Tyr). In this family, the novel mutation in the α2-globin gene resulted in a rare form of congenital cyanosis due to Hb-M. This hemoglobin was named Hb-MYantai. © 2010, Sociedade Brasileira de Genética.


Cao G.,Bin Zhou Medical University | Yu W.,Bin Zhou Medical University
Advanced Materials Research | Year: 2012

Atmospheric carbon dioxide levels increasing, the climate change has drawn increasing attention. But so far there is no good solution to this problem. This paper presents a simple and feasible way to achieve carbon dioxide liquefaction facility, to reduce carbon dioxide emissions, thereby to improve the climate of the new method. This method is not only technically simple and feasible but also quite inexpensive. © (2012) Trans Tech Publications.

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