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Yakymenko I.,R.E. Kavetsky Institute of Experimental Pathology | Tsybulin O.,Bila Tserkva National Agrarian University | Sidorik E.,R.E. Kavetsky Institute of Experimental Pathology | Henshel D.,Indiana University Bloomington | And 2 more authors.
Electromagnetic Biology and Medicine | Year: 2015

This review aims to cover experimental data on oxidative effects of low-intensity radiofrequency radiation (RFR) in living cells. Analysis of the currently available peer-reviewed scientific literature reveals molecular effects induced by low-intensity RFR in living cells; this includes significant activation of key pathways generating reactive oxygen species (ROS), activation of peroxidation, oxidative damage of DNA and changes in the activity of antioxidant enzymes. It indicates that among 100 currently available peer-reviewed studies dealing with oxidative effects of low-intensity RFR, in general, 93 confirmed that RFR induces oxidative effects in biological systems. A wide pathogenic potential of the induced ROS and their involvement in cell signaling pathways explains a range of biological/health effects of low-intensity RFR, which include both cancer and non-cancer pathologies. In conclusion, our analysis demonstrates that low-intensity RFR is an expressive oxidative agent for living cells with a high pathogenic potential and that the oxidative stress induced by RFR exposure should be recognized as one of the primary mechanisms of the biological activity of this kind of radiation. © 2015 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted Source


Yakymenko I.,Bila Tserkva National Agrarian University | Yakymenko I.,R.E. Kavetsky Institute of Experimental Pathology | Sidorik E.,R.E. Kavetsky Institute of Experimental Pathology
Experimental Oncology | Year: 2010

Intensive implementation of mobile telephony technology in everyday human life during last two decades has given a possibility for epidemiological estimation of long-term effects of chronic exposure of human organism to low-intensive microwave (MW) radiation. Latest epidemiological data reveal a significant increase in risk of development of some types of tumors in chronic (over 10 years) users of mobile phone. It was detected a significant increase in incidence of brain tumors (glioma, acoustic neuroma, meningioma), parotid gland tumor, seminoma in long-term users of mobile phone, especially in cases of ipsilateral use (case-control odds ratios from 1.3 up to 6.1). Two epidemiological studies have indicated a significant increase of cancer incidence in people living close to the mobile telephony base station as compared with the population from distant area. These data raise a question of adequacy of modern safety limits of electromagnetic radiation (EMR) exposure for humans. For today the limits were based solely on the conception of thermal mechanism of biological effects of RF/MW radiation. Meantime the latest experimental data indicate the significant metabolic changes in living cell under the low-intensive (non-thermal) EMR exposure. Among reproducible biological effects of low-intensive MWs are reactive oxygen species overproduction, heat shock proteins expression, DNA damages, apoptosis. The lack of generally accepted mechanism of biological effects of low-intensive non-ionizing radiation doesn't permit to disregard the obvious epidemiological and experimental data of its biological activity. Practical steps must be done for reasonable limitation of excessive EMR exposure, along with the implementation of new safety limits of mobile telephony devices radiation, and new technological decisions, which would take out the source of radiation from human brain. Copyright © Experimental Oncology, 2010. Source


Nepochatenko V.A.,Bila Tserkva National Agrarian University
Ferroelectrics | Year: 2010

The method of determination of functional dependence between parameters of crystalline lattice in ferroelastics and multiaxial ferroelectrics based on the condition of orientation matching of domains is offered. The analytical type of functional dependence has been found for phase transitions m3m-F4mm and 4/m-F2/m. We have compared theoretical results with experimental data for BaTiO3 and BiVO4. Copyright © Taylor & Francis Group, LLC. Source


Nepochatenko V.A.,Bila Tserkva National Agrarian University
Bulletin of the Russian Academy of Sciences: Physics | Year: 2010

A method for determining the functional dependence between lattice parameters from the condition of orientation correlation between domains in ferroelastics and multiaxial ferroelectrics is proposed. The obtained analytical dependences are compared with experimental data on BaTiO3 and PbTiO3 for the m3mF4mm phase transition. It is shown that the domain structure in PbTiO3 is strained. © 2010 Allerton Press, Inc. Source


Yakymenko I.,R.E. Kavetsky Institute of Experimental Pathology | Yakymenko I.,Bila Tserkva National Agrarian University | Sidorik E.,R.E. Kavetsky Institute of Experimental Pathology | Kyrylenko S.,Masaryk University | Chekhun V.,R.E. Kavetsky Institute of Experimental Pathology
Experimental Oncology | Year: 2011

In this review we discuss alarming epidemiological and experimental data on possible carcinogenic effects of long term exposure to low intensity microwave (MW) radiation. Recently, a number of reports revealed that under certain conditions the irradiation by low intensity MW can substantially induce cancer progression in humans and in animal models. The carcinogenic effect of MW irradiation is typically manifested after long term (up to 10 years and more) exposure. Nevertheless, even a year of operation of a powerful base transmitting station for mobile communication reportedly resulted in a dramatic increase of cancer incidence among population living nearby. In addition, model studies in rodents unveiled a significant increase in carcinogenesis after 17-24 months of MW exposure both in tumor-prone and intact animals. To that, such metabolic changes, as overproduction of reactive oxygen species, 8-hydroxi-2- deoxyguanosine formation, or ornithine decarboxylase activation under exposure to low intensity MW confirm a stress impact of this factor on living cells. We also address the issue of standards for assessment of biological effects of irradiation. It is now becoming increasingly evident that assessment of biological effects of non-ionizing radiation based on physical (thermal) approach used in recommendations of current regulatory bodies, including the International Commission on Non-Ionizing Radiation Protection (ICNIRP) Guidelines, requires urgent reevaluation. We conclude that recent data strongly point to the need for re-elaboration of the current safety limits for non-ionizing radiation using recently obtained knowledge. We also emphasize that the everyday exposure of both occupational and general public to MW radiation should be regulated based on a precautionary principles which imply maximum restriction of excessive exposure. Copyright © Experimental Oncology, 2011. Source

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