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Lee E.-J.,Sookmyung Womens University | Ji G.-E.,Seoul National University | Ji G.-E.,BIFIDO Co. | Sung M.-K.,Sookmyung Womens University
Inflammation Research | Year: 2010

Objective: We investigated the inhibitory effects of quercetin and kaempferol treatment on the suppression of immunoglobulin E (IgE)-mediated allergic responses in relation to intestinal epithelium barrier function in RBL-2H3 and Caco-2 cells. Methods: RBL-2H3 cells as a model of intestinal mucosa mast cells were treated with flavonols followed by IgE-anti-dinitrophenyl sensitization. The extent of degranulation and the release of pro-inflammatory cytokines were measured. Caco-2 cells were stimulated with interleukin (IL)-4 or IgE-allergen with or without flavonol pretreatment and changes in the expression of CD23 mRNA and mitogen-activated protein kinase (MAPK), and chemokine release were determined. Results: Flavonols inhibited the secretion of allergic mediators in RBL-2H3 cells and suppressed the CD23 mRNA expression and p38 MAPK activation in IL-4 stimulated Caco-2 cells. Flavonols also suppressed IgE-OVA induced extra signal-regulated protein kinase (ERK) activation and chemokine release. Conclusions: Quercetin and kaempferol effectively suppressed the development of IgE-mediated allergic inflammation of intestinal cell models. © 2010 Springer Basel AG.

Ju You H.,Seoul National University | Jin Ahn H.,Seoul National University | Ji G.E.,Seoul National University | Ji G.E.,BIFIDO Co.
Journal of Agricultural and Food Chemistry | Year: 2010

The flavonol quercetin in plants and foods occurs predominantly in the form of glycoside whose sugar moiety affects the bioavailability and the mechanism of its biological activities. The antiproliferative activities of quercetin derivatives such as quercetin aglycone, quercetin-3-ß-D-glucoside (Q3G), and rutin were compared using six different cancer cell lines including colon, breast, hepatocellular, and lung cancer. The IC50 value of Q3G ranged between 15 and 25 μM in HT-29, HCT 116, MCF-7, HepG2, and A549 cells. In these five cell lines, Q3G showed the most potent growth inhibition, whereas rutin showed the least potency. Transformation of rutin to Q3G was conducted by controlling R-L-rhamnosidase and ß-D-glucosidase activities from crude enzyme extract of Aspergillus niger. Carbon sources during culture and transformation conditions such as pH, temperature, and heatstability were optimized. After 4 h biotransformation, 99% of rutin was transformed to Q3G and no quercetin was detected. This study presented an efficient biotransformation for the conversion of rutin to Q3G which was newly shown to have more potent antiproliferative effect than quercetin and rutin. ©2010 American Chemical Society.

Lee K.J.,Seoul National University | Ji G.E.,Seoul National University | Ji G.E.,BIFIDO Co.
Journal of Ginseng Research | Year: 2014

Background: Understanding what causes changes in the flux of free fatty acids (FFA) is important to elucidate the etiology of metabolic syndrome. The first aim of this study was to test whether or not hormones and the autonomic nervous system influence blood FFA levels. A secondary aim was to test by means of a multiple group path analysis whether the consumption of fermented red ginseng (FRG; Panax ginseng) would influence those causal relationships. Methods: Ninety-three postmenopausal women (age 50-73 yr) were randomly divided into two groups. One group (44 women; age, 58.4±5.9 yr; body mass index, 23.6±2.5 kg/m2) was supplied placebo capsules and the other group (49 women, age 58.4±5.5 yr; body mass index, 22.9±2.4 kg/m2) was supplied FRG capsules. Both prior to and after the study (2 wk), blood samples were collected from the participants and several blood variables were measured and analyzed. Results: Squared multiple correlations of FFA were 0.699 in the placebo group and 0.707 in the FRG group. The unstandardized estimate of estradiol (E2) for FFA was 0.824 in both groups. Conclusion: The path coefficients of cortisol and the branchial pulse for FFA were significantly different between the FRG group and the placebo group. © 2014, The Korean Society of Ginseng, Published by Elsevier.

Bifido Co. | Date: 2016-01-11

Cosmetics; make-up; functional cosmetics; cosmetics for scalp; cosmetic preparations for bath and shower; cosmetics using biotechnology; cosmetic preparations for skin care and skin treatment. Bifidus probiotics for medical purposes; bifidus probiotics in powder form for medical purposes; vitamins and vitamin preparations; dietary supplements consisting primarily of iron; nutritional supplements consisting primarily of iron; ginseng capsules for medical purposes; diet capsules; vitamin and mineral preparations. Fermented milk products using bifidobacteria; milk with bifidobacteria; yogurt with bifidobacteria; cheese with bifidobacteria; processed red ginseng products; ginseng processed food products.

Bifido Co. | Date: 2016-01-25

Bifidus probiotics for medical purposes; powder form bifidus probiotics for medical purposes.

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