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Bielefeld, Germany

Bielefeld University is a university in Bielefeld, Germany. Founded in 1969, it is one of the country's newer universities, and considers itself a "reform" university, following a different style of organization and teaching than the established universities. In particular, the university aims to "re-establish the unity between research and teaching", and so all its faculty teach courses in their area of research. The university also stresses a focus on interdisciplinary research, helped by the architecture, which encloses all faculties in one great structure. It is among the first of the German universities to switch some faculties to Bachelor/Master-degrees as part of the Bologna process.Bielefeld University has started an extensive multi-phase modernisation project, which upon completion in 2025 would result in completely new university buildings to replace the 40-year old main building. A total investment of more than 1 billion euros has been planned for this undertaking. Wikipedia.

Forcada J.,Natural Environment Research Council | Hoffman J.I.,Bielefeld University
Nature | Year: 2014

Global environmental change is expected to alter selection pressures in many biological systems, but the long-term molecular and life history data required to quantify changes in selection are rare. An unusual opportunity is afforded by three decades of individual-based data collected from a declining population of Antarctic fur seals in the South Atlantic. Here, climate change has reduced prey availability and caused a significant decline in seal birth weight. However, the mean age and size of females recruiting into the breeding population are increasing. We show that such females have significantly higher heterozygosity (a measure of within-individual genetic variation) than their non-recruiting siblings and their own mothers. Thus, breeding female heterozygosity has increased by 8.5% per generation over the last two decades. Nonetheless, as heterozygosity is not inherited from mothers to daughters, substantial heterozygote advantage is not transmitted from one generation to the next and the decreasing viability of homozygous individuals causes the population to decline. Our results provide compelling evidence that selection due to climate change is intensifying, with far-reaching consequences for demography as well as phenotypic and genetic variation. © 2014 Macmillan Publishers Limited. All rights reserved. Source

Dietz K.-J.,Bielefeld University
Antioxidants and Redox Signaling | Year: 2011

Peroxiredoxins (Prx) are central elements of the antioxidant defense system and the dithiol-disulfide redox regulatory network of the plant and cyanobacterial cell. They employ a thiol-based catalytic mechanism to reduce H 2O 2, alkylhydroperoxide, and peroxinitrite. In plants and cyanobacteria, there exist 2-CysPrx, 1-CysPrx, PrxQ, and type II Prx. Higher plants typically contain at least one plastid 2-CysPrx, one nucleo-cytoplasmic 1-CysPrx, one chloroplast PrxQ, and one each of cytosolic, mitochondrial, and plastidic type II Prx. Cyanobacteria express variable sets of three or more Prxs. The catalytic cycle consists of three steps: (i) peroxidative reduction, (ii) resolving step, and (iii) regeneration using diverse electron donors such as thioredoxins, glutaredoxins, cyclophilins, glutathione, and ascorbic acid. Prx proteins undergo major conformational changes in dependence of their redox state. Thus, they not only modulate cellular reactive oxygen species-and reactive nitrogen species-dependent signaling, but depending on the Prx type they sense the redox state, transmit redox information to binding partners, and function as chaperone. They serve in context of photosynthesis and respiration, but also in metabolism and development of all tissues, for example, in nodules as well as during seed and fruit development. The article surveys the current literature and attempts a mostly comprehensive coverage of present day knowledge and concepts on Prx mechanism, regulation, and function and thus on the whole Prx systems in plants. © 2011 Mary Ann Liebert, Inc. Source

Wendisch V.F.,Bielefeld University
Current Opinion in Biotechnology | Year: 2014

Amino acids are produced at the multi-million-ton-scale with fermentative production of l-glutamate and l-lysine alone being estimated to amount to more than five million tons in the year 2013. Metabolic engineering constantly improves productivities of amino acid producing strains, mainly Corynebacterium glutamicum and Escherichia coli strains. Classical mutagenesis and screening have been accelerated by combination with intracellular metabolite sensing. Synthetic biology approaches have allowed access to new carbon sources to realize a flexible feedstock concept. Moreover, new pathways for amino acid production as well as fermentative production of non-native compounds derived from amino acids or their metabolic precursors were developed. These include dipeptides, α,ω-diamines, α,ω-diacids, keto acids, acetylated amino acids and ω-amino acids. © 2014 Elsevier Ltd. Source

Glaser T.,Bielefeld University
Chemical Communications | Year: 2011

Since the discovery that Mn12OAc acts as a single-molecule magnet (SMM), an increasing number of transition metal complexes have been demonstrated to behave as SMMs. The signature of a SMM is a slow relaxation of the magnetization at low temperatures accompanied by a magnetic hysteresis. The origin of SMM behaviour is the existence of an appreciable thermal barrier U for spin-reversal called magnetic anisotropy barrier which is related to the combination of a large total spin ground state (St) and an easy-axis magnetic anisotropy. The extensive research on Mn12OAc and other SMMs has established more prerequisites for a rational development of new SMMs besides the high-spin ground state and the magnetic anisotropy: the symmetry should be at least C3 to minimize the quantum tunneling of the magnetization through the anisotropy barrier but lower than cubic to avoid the cancellation of the local anisotropies upon projection onto the spin ground state. Based on these prerequisites, we have designed the ligand triplesalen which combines the phloroglucinol bridging unit for high spin ground states by the spin-polarization mechanism with a salen-like ligand environment for single-site magnetic anisotropies by a strong tetragonal ligand field. The C3 symmetric, trinuclear complexes of the triplesalen ligand (talent-Bu2)6- exhibit a strong ligand folding resulting in an overall bowl-shaped molecular structure. This ligand folding preorganizes the axial coordination sites of the metal salen subunits for the complementary binding of three facial nitrogen atoms of a hexacyanometallate unit. This leads to a high driving force for the formation of heptanuclear complexes [M t 6Mc]n+ by the assembly of three molecular building blocks. Attractive van der Waals interactions of the tert-butyl phenyl units of two triplesalen trinuclear building blocks increase the driving force. In this respect, we have been able to synthesize the isostructural series [MnIII 6CrIII] 3+, [MnIII 6FeIII]3+, and [MnIII 6CoIII]3+ with [Mn III 6CrIII]3+ being a SMM. A detailed analysis and comparison of the magnetic properties of the three heptanuclear complexes and the tetranuclear half-unit [MnIII 3Cr III]3+ provides significant insight for further optimization of the SMM properties. The modular assembly of the heptanuclear complexes from three molecular building blocks allows the fine-tuning of the molecular and steric properties of each building block without losing the driving force for the formation of the heptanuclear complexes. This possibility of rational improvements of our isostructural series is the main advantage of our supramolecular approach. © 2011 The Royal Society of Chemistry. Source

Golzhauser A.,Bielefeld University
Angewandte Chemie - International Edition | Year: 2012

Step by step: According to the molecular approach to the production of graphene, precursor molecules are cross-linked to form two-dimensional intermediates, and pyrolysis transforms the intermediates into graphene. This type of highly efficient synthesis of high-quality graphene is crucial to the development of innovative applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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