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Grant
Agency: European Commission | Branch: H2020 | Program: SME-2 | Phase: SMEInst-08-2016-2017 | Award Amount: 1.98M | Year: 2016

Omega-3 is an essential oil required by the body for proper functioning. It protects from cardiovascular diseases and improves the development and functioning of the skin as well nervous and visual system. Astaxanthin is a carotenoid pigment and is one of the most effective antioxidants to support human health. The global demand for Omega-3 and Astaxanthin for human consumption will require large quantities of both products: 260.000 tonnes of Omega-3 and 670 tonnes of Astaxanthin per year. This growing demand comes mainly from health conscious customer segment. This segment is also very interested in buying natural and eco-friendly products. However, their traditional extraction process from marine organisms (mainly fish and krill) is not sustainable: over fishing, high energy, raw materials consumption and a low efficiency. The majority of the marine resources are fully exploited or overexploited. The SME Neoalgae has designed an eco-innovative and sustainable industrial bioprocess for obtaining Omega-3 and Astaxanthin using marine microalgae as a natural source. This system is the answer to the growing demand in Omega-3 and Astaxanthin, especially in nutraceutical, cosmetic and pharmaceutical applications. With the new process, production of Omega-3 and Astaxanthin will not affect marine resources. Both products will be free of pollutants, without fishy aftertaste and odour free, apt for vegans, and with competitive and stable production costs. After the feasibility of the new products has been proved at a technical and market level, this SME-2 project will scale-up the production of both compounds and will demonstrate their effectiveness through their inclusion in nutraceuticals and in new ecological products for the treatment of 3 skin diseases: acne, atopic skin and aging skin produced by the SME Bicosome. Both companies will benefit from a dramatic boost in their sales and improve their market positions, as well as internationalising their businesses.


Fernandez E.,CSIC - Institute of Advanced Chemistry of Catalonia | Rodriguez G.,Bicosome | Cocera M.,Bicosome | Barbosa-Barros L.,Bicosome | And 5 more authors.
Physical Chemistry Chemical Physics | Year: 2015

Phospholipid-based nanostructures, bicelles and bicosomes, are proposed as carriers of the antioxidant β-carotene. The stability of these nanostructures and their carotenoid cargo was evaluated in an oxidation environment induced by ultraviolet A, visible and infrared A radiation (UVA-VIS-IRA). Additionally, the effect of these nanoaggregates on non-irradiated and irradiated skin microstructure was studied. The characterization of the lipid systems was performed using dynamic light scattering (DLS) and cryo-transmission electron microscopy (Cryo-TEM) and lipid peroxidation of the systems was determined by thiobarbituric acid (TBARS) assay. Moreover, the stability of β-carotene in these lipid systems under this radiation was investigated using Raman spectroscopy. The results showed that the particle size of the bicelles did not change due to radiation. However, the size of the bicosomes increased slightly after irradiation. The TBARS assay showed the absence of peroxides in the bicelles and bicosomes, indicating the preservation of the lipid molecules under the radiation used. Raman experiments showed that bicosomes protected β-carotene from degradation induced by radiation better than liposomes or dissolution in chloroform. With respect to the skin microstructure, no changes after irradiation were observed via freeze substitution transmission electron microscopy (FSTEM). This technique also showed the presence of vesicular structures in the stratum corneum (SC) after treatment with bicosomes. This journal is © the Owner Societies 2015.


Fernandez E.,CSIC - Institute of Advanced Chemistry of Catalonia | Fajari L.,CSIC - Institute of Advanced Chemistry of Catalonia | Rodriguez G.,Bicosome | Lopez-Iglesias C.,University of Barcelona | And 4 more authors.
RSC Advances | Year: 2014

In the present work, β-carotene antioxidant was incorporated in two different lipid nanoaggregates, bicelles and bicosomes, and its effectiveness against free radical formation in porcine skin in vitro was determined using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) spin trap and Electron Paramagnetic Resonance spectroscopy (EPR). Bicelles are discoidal nanostructures formed by self-assembly of phospholipids dispersed in aqueous solution. Bicosomes emerge as a strategy to stabilize and protect bicelles encapsulating these nanostructures in liposomes. Results from Dynamic Light Scattering (DLS) and cryo Transmission Electron Microscopy (cryo-TEM) demonstrated a slight modification in the size of both systems when β-carotene was incorporated. EPR revealed that after skin irradiation both systems presented free radical scavenging activity. This activity was statistically significant for bicosomes containing β-carotene. Differences regarding this scavenging activity between bicelles and bicosomes would probably be due to the different interaction of both systems with the skin. In this study, six different radicals were identified in skin spectra: two originated from oxygen centred radicals (primary/secondary and tertiary alkoxyl radicals) and another from carbon-centred radicals. Additionally, the presence of 5,5-dimethyl-2-oxo-pyrroline-1-hydroxyl (DMPO-OH), 5,5-dimethyl-2-oxo-pyrroline-1-hydrogen (DMPO-H) adducts and aminoxyl radicals (RR′NO) were detected. Considering these results, bicelles and bicosomes could be useful lipid systems for future dermopharmaceutical applications. © the Partner Organisations 2014.


PubMed | Bicosome and CSIC - Institute of Advanced Chemistry of Catalonia
Type: Journal Article | Journal: International journal of pharmaceutics | Year: 2016

Epidermal lamellar bodies (LBs) are organelles that secrete their content, mainly lipids and enzymes, into the intercorneocyte space of the stratum corneum (SC) to form the lamellar structure of this tissue. Thus, LBs have a key role in permeability and the microbial cutaneous barrier. In this work, a complex lipid system that mimics the morphology, structure and composition of LBs has been designed. To evaluate the effect of this system on delipidized SC, in vitro experiments using porcine skin were performed. The microstructure of SC samples (native, delipidized and, delipidized after treatment) was evaluated by freeze substitution transmission electron microscopy (FSTEM) and grazing-incidence small-angle X-ray scattering (GISAXS). Delipidized SC samples showed no evidence of lipid lamellae after extraction with organic solvents. However, after treatment with the LB mimetic system, new lamellar structures between corneocytes were detected by FSTEM, and high intensity peaks and reflections were found in the GISAXS pattern. These results demonstrate a strong effect of the treatment in repairing part of the lipid lamellar structure of the SC. Accordingly, future research could extend the use of this system to repair skin barrier dysfunction.


Rodriguez G.,CSIC - Institute of Advanced Chemistry of Catalonia | Barbosa-Barros L.,Bicosome | Rubio L.,CSIC - Institute of Advanced Chemistry of Catalonia | Cocera M.,Bicosome | And 5 more authors.
Journal of Biomedical Nanotechnology | Year: 2015

Bicelles have emerged as promising membrane models, and due to their attractive combination of lipid composition and physicochemical characteristics, they have become new nanostructures for biomedical research. Depending on the composition, temperature and other experimental factors, these nanosystems exhibit high structural and morphological versatility. Additionally, bicelles are able to modulate the biophysical parameters and barrier function of skin. Given these properties, these nanostructures appear to be smart nanosystems with great potential in biomedicine and dermopharmacy.


Bicosome | Entity website

Conditions of Use Access to and use of this website are subject to the following conditions. Please do not use this website unless you agree with these conditions ...


Bicosome | Entity website

Copyright 2016 Bicosome. All Rights Reserved


Bicosome | Entity website

El Bicosome Filling up System (Bicosome FS) es un ingrediente inteligente para el cuidado de la piel que encapsula y libera una combinacin seleccionada de lpidos formadores de bicapas. La matriz lipdica natural de la piel se estructura en bicapas lipdicas, que se encargan de la funcin barrera de la piel ...


Bicosome | Entity website

Les radiacions que incideixen a la superfcie de la Terra i que, per tant, afecten la pell sn els raigs UVB, UVA i IR. Una exposici excessiva a aquestes radiacions pot debilitar el mecanisme de defensa innat de la pell, la qual cosa provoca estrs oxidatiu i la formaci despcies reactives doxigen (ROS), i aquestes, al seu torn, causen laparici de signes de fotoenvelliment ...


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